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close this bookControlling Insect Pests of Stored Products Using Insect Growth Regulators and Insecticides of Microbial Origin (NRI, 1994, 58 p.)
close this folderSection 2: Insect growth regulators: general account
View the document(introduction...)
View the documentChitin inhibitors
View the documentJuvenile hormone and juvenile hormone analogues
View the documentAnti-juvenile hormones
View the documentInsecticide development and registration
View the documentReview of insect growth regulators
View the documentEffect of insect growth regulators on non-target organisms

Anti-juvenile hormones

Once the effects of JH and JHAs had been demonstrated, research was directed towards determining the effect of their absence prior to the final larval instar.
Bowers (1976) discovered that extracts from the plant Ageratum houstonianum cause premature metamorphosis in some Hemiptera. It was subsequently shown that the active molecules, or precocenes, destroy the glands (corpora allata) which produce JH after first being converted to highly reactive metabolites by tissue-specific enzymes within the glands (Menn et al., 1989).

Screening led to the discovery of anti-JHs such as fluoromevalonate (FMev). FMev showed activity against virtually all the Lepidoptera in which it was tested but little in other insect orders.

Although anti-JHs have become useful research tools, none have shown sufficient promise to be developed as practical pest control agents. Also, precocenes have been found to be toxic to the liver and kidneys of vertebrates (Steal, 1 986).