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close this bookControlling Insect Pests of Stored Products Using Insect Growth Regulators and Insecticides of Microbial Origin (NRI, 1994, 58 p.)
close this folderSection 2: Insect growth regulators: general account
View the document(introduction...)
View the documentChitin inhibitors
View the documentJuvenile hormone and juvenile hormone analogues
View the documentAnti-juvenile hormones
View the documentInsecticide development and registration
View the documentReview of insect growth regulators
View the documentEffect of insect growth regulators on non-target organisms

Insecticide development and registration

IGRs are arthropod-specific and as they are not neurotoxic, they are potentially less harmful to man and other vertebrates than conventional insecticides. The agrochemical industry has screened many compounds for potential IGR activity and isolated a number of active compounds.

If IGR activity is identified, a compound is given a company registration number and is then tested to determine its specificity against a range of economically important insect pests. For registration purposes, promising materials are also evaluated for their physico-chemical properties, mammalian and avian toxicity, effects, if any on the environment, and toxicity to other wildlife.

Before they can be used as grain protectants, compounds must first gain approval by the Joint FAO/WHO Meeting on Pesticide Residues (JMPR) which establishes the acceptable daily intake (ADI) levels and maximum residue limits (MRL) on produce. Once these levels have been approved, protectants are submitted to the Codex Committee on Pesticide Residues (CCPR). The CCPR carries out an 1 1 -step procedure to establish internationalIy acceptable MRLs for the food commodities moving in international trade. These standards are then recommended to governments by the Codex Alimentarius Commission.