FAO manual on the submission and evaluation of pesticide residues data for the estimation of maximum residue levels in food and feed (1997)

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PREFACE

ACKNOWLEDGEMENT

1. INTRODUCTION

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1.1 Historical background

1.2 The object of the work of JMPR

1.3 The JMPR assessment process

2. SELECTION OF COMPOUNDS FOR EVALUATION

2.1 Selection of new compounds

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2.1.1 Procedure for proposing pesticides for Codex Priority List

2.2 Periodic review of old compounds

2.3 Re-evaluation of compounds

3. DATA AND INFORMATION REQUIRED FOR JMPR EVALUATIONS

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3.1 New and periodic review compounds

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3.1.1 Identity

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3.1.1.1 Physical and chemical properties

3.1.1.2 Formulations

3.1.2 Metabolism and environmental fate

3.1.3 Methods of residue analysis and stability of pesticide residues in stored analytical samples

3.1.4 Use pattern

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3.1.4.1 Explanatory notes for presenting GAP information

3.1.5 Residues resulting from supervised trials

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3.1.5.1 Information and data from livestock transfer (feeding) and external animal treatment studies

3.1.5.2 Information on veterinary uses

3.1.6 Fate of residues in storage and processing

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3.1.6.1 Information and data from trials on stored products

3.1.6.2 Information and data on residues in processed food

3.1.6.3 Information and data on residues in the edible portions of food commodities

3.1.7 Residues in food in commerce and consumption

3.1.8 National Maximum Residue Limits

3.2 Reconsideration of previous recommendations

3.3 Data requirements for ERL estimation

4. PREPARATION OF DATA SUBMISSIONS FOR THE CONSIDERATION OF THE FAO PANEL OF JMPR

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4.1 Standardised format of the directory

4.2 Standardised format of the working paper/monograph

4.3 Organization of the submission

5. THE JMPR PRACTICE IN ESTIMATING MAXIMUM RESIDUES LEVELS AND PROPOSING MAXIMUM RESIDUE LIMITS

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5.1 Evaluation of available information

5.1.1 Chemical and physical properties of a pesticide

5.1.2 Metabolism and degradation of pesticides after application on plants, animals and soil

5.1.3 Information received on Good Agricultural Practices

5.1.4 Residue data

5.1.4.1 Results of supervised trials

5.1.4.2 Results of selective surveys

5.1.5 Processing studies

5.1.6 Results of national monitoring programmes

5.2 Re-evaluation of compounds

5.2.1 Re-evaluation of additional information

5.2.2 Re-evaluation of compounds being in the CCPR periodic review programme

5.3 Definition of residues

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5.3.1 Principles followed in defining residues for MRLs

5.4 Estimation of maximum residue levels

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5.4.1 Specific considerations in estimating maximum residue levels

5.4.2 Estimation of group maximum residue levels

5.4.3 Estimation of extraneous residue levels (ERL)

5.5 Expression of Maximum Residue Limits

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5.5.1 Expression of Maximum Residue Limits at or about the limit of determination

5.6 Recommendations for Maximum Residue Limits

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5.6.1 Recommendation of Temporary MRLs

5.6.2 Estimation of Guideline Levels

6. ESTIMATION OF RESIDUE LEVELS FOR CALCULATION OF DIETARY INTAKE OF PESTICIDE RESIDUES

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6.1 Guidelines for predicting dietary intake

6.2 Estimation of supervised trial median values

7. USE OF JMPR RECOMMENDATIONS BY REGULATORY AUTHORITIES

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7.1 Safety assessment of pesticides

7.2 Residue studies and recommended MRLs

7.3 Interpretation of residue analytical results in comparison with MRLs

8. REFERENCES

APPENDICES

Appendix I. ABBREVIATIONS USED IN THE TEXT

Appendix II. GLOSSARY OF TERMS

Appendix III. CIPAC CODES FOR PESTICIDE FORMULATIONS

Appendix IV. MRL PERIODIC REVIEW PROCEDURE BY CCPR

Appendix V. RECOMMENDED SAMPLING METHOD FOR SUPERVISED FIELD TRIALS5

Appendix VI. PORTION OF COMMODITIES TO WHICH CODEX MAXIMUM RESIDUE LIMITS APPLY AND WHICH IS ANALYSED9

Appendix VII. STANDARDIZED FORMAT FOR ORGANIZING THE DATA DIRECTORY (INDEX) OF INFORMATION TO BE SUBMITTED FOR EVALUATION

Appendix VIII. PESTICIDE INFORMATION FOR CCPR WORKING GROUP ON PRIORITIES14

Appendix IX. MAXIMUM PROPORTION OF AGRICULTURAL COMMODITIES IN ANIMAL FEED

Appendix X. JMPR MANUAL FOR FAO PANEL MEMBERS