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close this bookFood Composition Data: A User's Perspective (UNU, 1987, 223 pages)
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close this folderExperiences with food composition data: the context
close this folderINFOODS: Background and current status
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View the documentGrowing need for and availability of information on components of foods
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View the documentINFOODS - an international network of food data systems: a framework for discussion
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close this folderData: the user context
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close this folderThe INFOODS system
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close this folderThe uses of food composition data
close this folderNeed for a standardized nutrient data base in epidemiologic studies
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View the documentLimitations of diet-related epidemiologic studies
View the documentFactors influencing diet-related epidemiologic studies, using diet and colon cancer studies as an illustration
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close this folderEpidemiological uses of food composition data in the European context
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close this folderNCI food data needs: impact on coding systems
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close this folderFood composition -a key to dietary appraisal and improvement in the United States
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close this folderUsing food composition data to communicate nutrition to the consumer
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View the documentNUTREDFO system development
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close this folderNutrient composition data uses and needs of food companies
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close this folderManaging food composition data
close this folderConcerns of users of nutrient data bases
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close this folderManaging food composition data at the national level
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close this folderMaintaining a food composition data base for multiple research studies: the NCC food table
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close this folderManaging a nutrient data-base system: meeting users' needs and expectations
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View the documentThe HVH-CWRU nutrient data-base system
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close this folderInternational food composition data
close this folderNutrient intake data calculated using food composition tables: factors affecting accuracy
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close this folderThe status of food composition data in Asia
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close this folderFood composition data in Sweden and the nordic countries
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close this folderFood data in Canada: the Canadian nutrient file
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close this folderA system for evaluating the quality of published nutrient data: Selenium, a test case
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close this folderConsideration of food composition variability: What is the variance of the estimate of one-day intakes? Implications for setting priorities
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close this folderDietary assessment methods used by the national health and nutrition examination surveys (NHANES)
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close this folderSystems considerations in the design of INFOODS
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Factors influencing diet-related epidemiologic studies, using diet and colon cancer studies as an illustration

Searching on the key words "diet or dietary" and "colon cancer," "colonic neoplasms," or "sigmoid neoplasms," a MEDLINE literature search yielded 166 citations dating back to 1980. Twenty-six or 16 per cent of these studies were population-based or epidemiologic in nature. Thirty-three population-based studies reported after 1977 were identified by cross-referencing colon cancer with dietary risk factors. These studies have been summarized in table 1. The studies have been grouped according to the most commonly cited dietary risk/protective factors: dietary fibre, fat/meat, beer/alcohol, and cruciferous vegetables. The headings in table 1 list major components of epidemiological studies, each of which can effect the outcome of the study. The major types of study design as seen in the table are: ecological and food disappearance studies, retrospective (case-control) studies, cross-sectional surveys, and prospective (cohort) studies. In addition to choosing the appropriate study design, the investigator must also decide how to collect dietary information.

Though there are many variations of each, there are four basic dietary data collection tools: diet diaries, diet recalls, diet histories, and food frequencies. If data on specific food or foodgroup intake or availability is obtained for individuals or groups. the information can be transformed into nutrient intake by interfacing the food intake data of study respondents with a food composition data base.

Each technique has inherent strengths and weaknesses. Retrospective data collection methods are subject to respondent memory bias while diary methods tend to distort usual intake patterns. In addition these standard methods measure different aspects of dietary intake. Therefore there will be differences in study outcome depending on the food-intake datacollection instrument chosen. (Notice that all four intake tools were employed in the studies reported in table!.)

The type of food or nutrient data base selected is dependent on the study design, the data collection method, the study objectives, and the endpoints to be measured. However, a lack of standardized definitions of dietary study variables has been a major weakness in interpreting study outcomes. Definition has presented problems for developing standardized food names as well as for food composition tables. For example, dietary fibre, the first risk factor listed in table 1, is a complex of a number of physically and chemically different entities found in foods. They include cellulose, hemicellulose, lignins, pectins, and gums, and the ratio of these materials varies in fibre-containing foods. Until recently, data bases reported only crude fibre values, in which food samples were subjected to strong acid and then alkali solutions. These values are not equivalent to dietary fibre, which is the residue of undigested food.

The last column in the table describes the outcome or risk-factor association found in the studies. Drawing correct conclusions from the data concerning the strength of association of study variables and the attributable risk for diseases is dependent on choosing appropriate statistical tests. In addition one must control for confounding variables and adjust for covariables. Unlike other clinical or laboratory studies, epidemiological studies are based mainly on relative rather than absolute differences of risk factors between exposed and unexposed groups. However, these studies lose power if real differences exist in the nutrient content of foods consumed by different population groups. This problem is analogous to regressing to the mean by not utilizing significant differences in food composition consumed by study populations. Increasing the power of a study is important, since the influence of diet is often obscured by stronger overriding etiological factors encountered in multi-etiological chronic disease studies. Also, epidemiologic methods and techniques are sometimes inadequate or inappropriate for the evaluation of diet and disease relationships, especially if one assumes that nutrient variables are independent of other dietary or environmental factors. Furthermore, much of the confusion in outcomes of diet-related epidemiologic research may stem from inappropriately comparing studies that differ in design, analytical techniques, or food composition data bases.