Abstract
To assess the importance of vitamin A deficiency, an epidemiological
survey of the prevalence of xerophthalmia was conducted, and serum retinal
levels, nutritional status, and dietary habits were measured in southern Rwanda
in November and December 1987 Cluster sampling was used to identify 5,629
children under six years of age. Ophthalmological examination revealed 74 cases
of Bitot's spots for a prevalence of 1.31% (95% CI, 1.00 to 1.69). Serum retinal
levels <0.70 µmol/L were found in 21.3% of children. Both of these measures
exceed levels considered by WHO/UNICEF to indicate a severe public health
problem of vitamin A deficiency. The mean retinol levels for children with
Bitot's spots, matched controls, and a representative sample of the population
were 0.75 µmol/L (95% CI, 0.65 to 0.851, 0.95 µmol/L (95% CI, ass to 7.05), and
1.04 µmol/L (95% CI, 0.98 to 1.09), respectively. The interrelationships among
serum retinol levels, nutritional status, food intake, and Bitot's spots are
discussed.