Vitamin B1 (Thiamine), Vitamin B6, (Pyridoxine), Vitamin B12 (Cobalamin)

Plasma levels of the B vitamins have been related to diverse pregnancy outcomes with varying results. The recognised potential of homocysteine in playing a role in pre-eclampsia has also triggered research in the role of vitamin B12 in pregnancy. Do date no controlled supplementation studies are available to prove that supplements are needed during pregnancy unless in situations where there is clinical evidence of a specific deficiency where the treatment is needed to correct the clinical picture. Table 1 gives an overview of the available evidence.