Business Week (5/27) has listed Ann Arbor-based KnowledgeWare as #2 on its Hot Growth List of all U.S. companies. KnowledgeWare is the fastest-growing company in the $450M CASE industry, with sales up 100% last year. ($66.2M on $9.8M profits.) IBM owns 9% of the company, which develops DOS and OS/2 software.