
| New Data on the Prevention of Mother-to-Child Transmission of HIV and Their Policy Implications (UNAIDS, 2001, 24 p.) |
| Conclusions and recommendations regarding infant feeding |
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In one trial, the risk of dying in the first 2 years after delivery was greater among HIV-infected women who were randomized to breastfeeding than among those who were randomized to formula feeding.54 This result has yet to be confirmed by other research.
Women who do not breastfeed or stop breastfeeding early are at greater risk of becoming pregnant.
Recommendation: HIV-infected women should have access to information, follow-up clinical care and support, including family planning services and nutritional support. Family planning services are particularly important for HIV-infected women who are not breastfeeding.
Regimens of proven efficacy (randomized controlled clinical trials)
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Antepartum |
Intrapartum |
Postpartum/postnatal | ||||
|
Study |
Drug |
14-28 wks |
28-36 wks |
>36 wks |
Labour |
1 wk PP |
1-6 wks PP |
|
ACTG 076 |
ZDV | | |
Infant | |||
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Harvard Thai |
ZDV | | | |
Infant | ||
|
Harvard Thai |
ZDV | | | |
Infant | |
|
|
Harvard Thai |
ZDV | | | |
Infant | ||
|
Harvard Thai |
ZDV | | | |
Infant | |
|
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DITRAME |
ZDV | | | |
Mother | |
|
|
CDC |
ZDV | | | | | ||
|
PETRA Arm A |
ZDV + 3TC |
| | |
Mother and Infant |
| |
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PETRA Arm B |
ZDV + 3TC |
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Mother and Infant |
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HIVNET/SAINT |
NVP | | |
Infant | |
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