Oral drugs

Acetaminophen
Acetyl salicylic acid = ASA
Albendazole
Albuterol
Aluminium hydroxide
Aminophylline
Amoxicillin
Ampicillin
Aneurin
Ascorbic acid
Atropine sulphate
B Complex
Butylscopolamine
Charcoal
Chloramphenicol
Chloroquine
Chlorpheniramine = Chlorphenamine
Chlorpromazine
Cimetidine
Clofazimine
Cloxacillin
Cotrimoxazole = SMX + TMP
Dapsone
Dexamethasone
Dexchlorpheniramine
Diazepam
Diethylcarbamazine
Digoxin
Dihydralazine
Dipyrone*
Doxycycline
Erythromycin
Ethambutol
Ferrous salts = Ferrous sulphate
Ferrous sulphate + Folic acid
Flubendazole
Folic acid
Furosemide = Frusemide
Griseofulvin
Halofantrine*
Hydralazine
Hydrochlorothiazide
Hyoscine butylbromide
Ibuprofen
Indometacin
Iron salts
Isoniazid = INH
Isoniazid + Thiacetazone
Ivermectin
Levamisole
Loperamide
Mebendazole
Mefloquine
Metamizol*
Methyldopa
Methylprednisolone
Metoclopramide
Metrifonate
Metronidazole
Multivitamins
Niclosamide
Nitrofurantoin
Noramidopyrine*
Noscapine
Nystatin
Oral rehydration salt = O.R.S.
Oxamniquine
Oxytetracycline
Paracetamol
Phenobarbitone = Phenobarbital
Phenoxymethyl penicillin = Penicillin V
Phenylbutazone*
Phenytoin
Piperazine
Potassium chloride
Praziquantel
Prednisolone- Prednisone
Probenecid
Proguanil
Promethazine
Propanthelin
Propranolol
Pyrantel
Pyrazinamide
Pyridoxine
Quinine salts
Reserpine
Retinol
Rifampicin
Salbutamol
Sulfadimidine
Sulfadoxine + Pyrimethamine
Sulfaguanidine*
Tetracycline
Theophylline
Thiabendazole
Thiamine
Tolbutamide
Vitamin A
Vitamin B1
Vitamin B6
Vitamin C
Vitamin B Complex

* The use of this drug is not advised.

ACETYL SALICYLIC ACID = A.S.A.

(Aspirin)

Health post

Therapeutic action

- Analgesic
- Antipyretic
- Anti-inflammatory

Indications

- Headache, toothache
- Fever
- Joint or muscular pain

Preparation

- Tablets of 75 mg, 100 mg, 300 mg and 500mg

Dosage

- Child: 50 mg/kg/d divided in 3 doses
- Adult: 1-3 g/d divided in 3 doses
- In case of joint pain, double the dose.

FIGURE

Duration: depending on clinical progress, 1-3 days

Contra-indications, side-effects, precautions

- Do not administer:

· in cases of heartburn, alcoholism, haemorrhage, asthma.
· children under one year (preferably use paracetamol when available).

- If heartburn or allergic reaction, stop treatment and give paracetamol.
- Do not combine with probenecid.
- Pregnancy: avoid if possible (preferably use paracetamol especially in the third trimester of pregnancy)
- Lactation: avoid if possible (preferably use paracetamol)

Remarks

- Take during meals, preferably",with a lot of water.
- Storage: keep cool if possible
- Do not use if the tablets have a strong unusual smell (acid or vinegar). A slight acetic acid smell is always present.

ALUMINIUM HYDROXIDE [with or without magnesium salts]

Health post

Therapeutic action

- Antacid
- Protects digestive mucosa

Indications

- Heartburn after or during meals (gastritis)
- Stomach ulcer

Preparation

- Tablet of 500 mg There are numerous preparations on the base of aluminium and/or magnesium hydroxide in varying dosages. Adapt dosage accordingly.

Dosage

- Child: rarely indicated. When necessary: 75 mg/kg/d
- Adult: 1.5 to 3 g/d divided in 3 doses after meals or at the time of extreme pain

FIGURE

Duration :5 days (longer if necessary)

Contra-indications, side-effects, precautions

- Frequent constipation (except when the tablets contain magnesium salts).
- Decreases the absorption of many drugs so avoid simultaneous administration especially with tetracycline. Separate the different drugs by one or two hours.
- Chew tablets.
- Besides this treatment, the patient should avoid taking alcohol, coffee, tea, coca-cola, carbonated drinks, spices and tobacco.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Storage: no special precautions

AMINOPHYLLINE (Euphyllin(R), Theodrox(R).) and THEOPHYLLINE (Nuelin(R).)

District hospital

Therapeutic action

- Bronchodilator

Indications PRESCRIPT/ONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Asthma
- Severe respiratory problems combined with bronchopneumonia

Preparation

- Tablets of 100 mg and 200 mg

Dosage

- Child and adult:

· Aminophylline: 13 to 15 mg/kg/d divided in 3 doses
· Theophylline : 10 to 13 mg/kg/d divided in 3 doses

- For smokers, it is sometimes necessary to increase the dosage to 20 mg/kg/d.
- Aminophylline contains 85% of theophylline.

FIGURE

Duration: depending on clinical progress

Contra-indications, side-effects, precautions

- Paediatrics:

· do not combine with erythromycin.
· the therapeutic dose is near the toxic dose.

- Toxic in case of overdose:

· early signs: vomiting, hyperthermia.
· signs of intoxication: convulsions.

When these symptoms appear, stop treatment and refer to a doctor as soon as possible.

- Lower the dosage in case of heart failure.
- Administer with care to children under one year.
- Avoid combination with phenobarbitone.
- Pregnancy: avoid (especially in the third trimester of pregnancy)
- Lactation :avoid

Remarks

- Storage: keep below 30°C

AMOXICILLIN (Amoxil(R), Clamoxyl(R).)

Health clinic

Therapeutic action

- Antibacterial (antibiotic) of the penicillin group

Indications

- Respiratory infections with fever in children under 5 years
- Prevention and treatment of secondary infections of whooping cough and measles
- Genito-urinary infections, especially in pregnant women

Preparation

- Tablets or capsules of 500 mg and 250 mg
- Syrup of 125 mg/5 ml = 1 teaspoon (tsp)

Dosage

- Child : 50 mg/kg/d divided in 2 doses
- Adult: 1 to 2 g/d divided in 2 doses
- In case of severe infections, use the maximum dosage in 3 doses/day.
- Treatment of genito-urinary infections in pregnant women: 1 g/d divided in 2 or 3 doses for 10 days.

FIGURE

Duration

- Minimum 5 days
- 10 days in case of genito-urinary infections in pregnant women

Contra-indications, side-effects, precautions

- Do not administer if known allergy to penicillin.
- If allergic reaction, stop treatment and refer to a doctor.
- Do not combine with other antibiotics without medical advice.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Amoxicillin is used for the same indications as ampicillin but, because of its better intestinal absorption, only half the dose is required by oral administration.
- Storage: keep cool if possible.
Once prepared, the syrup should be kept cool, and will only last for 1 week.

AMPICILLIN (Amfipen(R), Penbritin(R).)

Health clinic

Therapeutic action

- Antibacterial (antibiotic) of the penicillin group

Indications

- Respiratory infections with fever in children under 5 years
- Prevention and treatment of secondary infections of whooping cough and measles
- Genito-urinary infections, especially in pregnant women

Preparation

- Tablets or capsules of 500 mg and 250 mg - Syrup of 125 mg/5 ml = 1 teaspoon (tsp)

Dosage

- Child: 100 mg/kg/d divided in 2 doses
- Adult: 2 to 4 g/d divided in 2 doses
- In case of severe infections, use the maximum dosage in 3 doses/day.
- Treatment of genito-urinary infections in pregnant women: 1 g/d divided in 2 or 3 doses for 10 days.

FIGURE

Duration

- Minimum 5 days
- 10 days in case of genito-urinary infections in pregnant women

Contra-indications, side-effects, precautions

- Do not administer if known allergy to penicillin.
- If allergic reaction, stop treatment and refer to a doctor.
- Do not combine with other antibiotics without medical advice.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Avoid to take ampicillin during meals.
- Amoxicillin is used for the same indications as ampicillin but, because of its better intestinal absorption, only half the dose is required by oral administration.
- Storage: keep cool if possible.

Once prepared, the syrup should be kept cool, and will only last for 1 week.

ASCORBIC ACID = VITAMIN C (Redoxon(R).)

District hospital

Therapeutic action

- Vitamin

Indications

- Treatment and prevention of scurvy

Preparation

- Tablets of 50 mg and 250 mg

There are also tablets of 500 mg and 1 g. Adapt dosage accordingly.

Dosage

- Treatment:

child: 100 to 300 mg/d divided in 3 doses
adult: 500 mg to 1 g/d divided in 3 doses

- Prevention:

child: 50 to 100 mg/d
adult: 50 to 100 mg/d

FIGURE

Duration

- Treatment: 1 to 2 weeks until symptoms improve, followed by a maintenance dose for 2 weeks (preventive dose).
- Prevention: as long as the situation requires (e.g. insufficient supply in the food rations of displaced population).

Contra-indications, side-effects, precautions

- Well tolerated.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- High doses of vitamin C can interfere with the measurement of glucose in urine.
- This supplement is rarely necessary when the food intake contains enough fruit and vegetables.
- Storage: keep below 30°C

ATROPINE Sulphate
HYOSCINE BUTYLBROMIDE = BUTYLSCOPOLAMINE (Buscopan(R).) PROPANTHELIN (Probanthine(R).)

District hospital

Therapeutic action

- Antispasmodic

Indications

- Spasms of the digestive and uro-genital tract

Preparation

- Atropine sulphate : tablet of 1 mg
- Hyoscine butylbromide: tablet of 10 mg
- Propanthelin : tablet of 15 mg

Dosage

- Child: avoid
- Adult:
atropine sulphate : 3 mg/d divided in 3 doses
hyoscine butylbromide: 30 to 60 mg/d divided in 3 doses
propanthelin : 45 to 90 mg/d divided in 3 doses
- Butylhyoscine or propanthelin are to be preferred since their side-effects are less pronounced than those of atropine.

FIGURE

Duration: depending on clinical progress, maximum 1 to 4 days

Contra-indications, side-effects, precautions

- Do not administer in cases of:

· urinary retention,
· cardiac problems,
· glaucoma.

- May cause:

· dry mouth,
· constipation,
· dizziness, headache.

- Do not combine with chlorpromazine or promethazine.
- Pregnancy: avoid, particularly in the third trimester of pregnancy, NO PROLONGED TREATMENTS
- Lactation: avoid, NO PROLONGED TREATMENTS

Remarks

- Do not use for convenience.
- Storage:

CHARCOAL

District hospital

Therapeutic action

- Absorbent

Absorbs toxic substances of certain plants and drugs and those produced by some microbes.

Indications

- Intoxication after taking drugs in higher doses than normal (A.S.A., paracetamol, chloroquine, quinine, barbiturates, indometacin, phenytoine, digoxine, tolbutamide, theophylline...)
- Poisoning by plants

Preparation

- Tablet of 125 mg

There are different strengths. Adapt dosage accordingly.

Dosage

- Child and adult: 6 to 24 tablets in a single dose
- In case of severe overdose: 30 tablets in a single dose.

FIGURE

Duration: single dose; repeat if necessary.

Contra-indications, side-effects, precautions

- Do not administer after ingestion of caustic products.
- Constipation possible after treatment.
- Black colouring of faeces.
- Do not administer with other drugs, because of its absorbing properties.
- Pregnancy: no contra-indication (avoid prolonged use)
- Lactation: no contra-indication

Remarks

- Charcoal DOES NOT CURE DIARRHOEA. It does not correct dehydration. It can only relieve a blown up stomach.
- To make this drug easier to take, crush the tablets.
- Storage: no special temperature requirements

CHLORAMPHENICOL (Chloromycetin(R), Tifomycine(R).)

District hospital

Therapeutic action

- Antibacterial (antibiotic)

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Typhoid fever
- Meningitis
- Bronchopneumonia

Preparation

- Tablet or capsule of 250 mg
- Syrup of 125 mg/5 ml

Dosage

- Child under 2 months: 25 mg/kg/d divided in 3 doses
- Child above 2 months: 50 to 100 mg/kg/d divided in 3 doses
- Adult :1 to 3 g/d divided in 3 doses

FIGURE

- Typhoid: refer to national protocol. In other cases, start the first day with a half dose and increase gradually.
- For indications other than typhoid, do not exceed the total dose of 26 g for adults.
- Can be used for immediate treatment of gonorrhoea: 2 to 3 g once daily for 2 days.

Duration

- 5 days minimum
- Typhoid fever: continue the antibiotic therapy 15 days after the fever has gone.

Contra-indications, side-effects, precautio- In newborn babies, administer only for cases of typhoid or meningitis.

- If treatment causes anaemia, stop treatment and refer to a doctor.
- Do not combine with other antibiotics without medical advice.
- As far as possible, limit the use of chloramphcol to serious infections.
- Pregnancy: CONTRA-INDICATED
- Lactation: CONTRA-INDICATED

Remarks

- In spite of a rare severe haematological toxicity, the use of chloramphenicol is justified because of its effective treatment of the above mentioned severe infections. Another advantage is the low price.
- The oral treatment is more effective than the injected (I.M.), as the blood- and tissue concentrations are better.
- Storage: keep below 30°C if possible-

Once prepared, the syrup should be kept cool, and will only last for 1 week.

CHLOROQUINE Phosphate or Sulphate (Nivaquine(R), Resochin(R).)

Health post

Therapeutic action

- Antimalarial

Indications

- Malaria

· Treatment of a malaria attack (in areas without chloroquine resistance)
· Prophylaxis for pregnant women, malnourished children and non-immune individuals in areas without chloroquine resistance

Preparation

- Tablet of 100 mg of chloroquine base
- Tablet of 150 mg of chloroquine base

IMPORTANT: THE DOSE WRITTEN ON THE LABELS IS SOMETIMES IN CHLOROQUINE SALT AND SOMETIMES IN CHLOROQUINE BASE WHICH LEADS TO FREQUENT CONFUSION. WHO RECOMMENDS PRESCRIPTIONS AND LABELS IN CHLOROQUINE BASE.

Equivalence for salt and base: 130 mg sulphate = 150 mg phosphate or diphosphate = 100 mg base 200 mg sulphate = 250 mg phosphate or diphosphate = 150 mg base

Dosage

PREVENTIVE TREATMENT

When there is no national protocol, apply one of the following schemes, depending on local practice:

FIGURE

CURATIVE TREATMENT

When there is no national protocol, administer in the following way:

- Child and adult: 10 mg base/kg, D1 and D2 5 mg base/kg, D3, D4 and D5
- When treatment schedule must be very simple, it is possible to give 10 mg base/kg/d for 3 days.
- When using injectable chloroquine, never forget that the therapeutic oral dose is equivalent to a toxic dose when injected.

FIGURE

Duration: curative treatment: 5 or 3 days

Contra-indications, side-effects, precautions

- Vomiting and frequent headaches.
- Pruritis, cutaneous eruptions possible, most of them occurring in areas of endemic filariasis. These are not allergic reactions and treatment should not be stopped.
- Do not come near the toxic dose:

· child: 25 mg base/kg in one dose 2 g base in one dose
· adult: 2 g base in one dose

Intoxication is severe.

- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

PREVENTIVE TREATMENT

- The prevention of malaria in areas with high prevalence of chloroquine resistance is often debated. In this case, chloroquine has to be combined with proguanil or replaced by a different drug.
- Travellers only have to start treatment on the day of their arrival in affected areas. Treatment must be continued for 6 weeks after leaving the area.

CURATIVE TREATMENT

- When it is not possible to take two doses on the first day, give the total dose of the first day at once, 15 mg base/kg.
- If the patient vomits within one hour of medication being given, repeat the dose.
- Some national guidelines recommend to give only the first dose of treatment (conservation of natural immunity of population).
- It is advisable to use tablets of 150 mg base (= 250 mg of phosphate) in english speaking countries and 100 mg base (= 150 mg of phosphate) in french speaking countries to mountain local practice and to avoid mistakes in dosage.
- Storage: no special temperature requirements -

CHLORPHENIRAMINE = CHLORPHENAMINE (Teldvin(R).)

District hospital

Therapeutic action

- Antihistamic

Indications

- Allergic reactions due to:

· contact, seasons.
· drugs, insect bites, food.

- Dry cough of allergic origin

Preparation

- Tablet of 4 mg

Dosage

- Child (above 2 years): 1 to 4 mg/d divided in 2 or 3 doses
- Adult: 8 to 12 mg/d divided in 2 or 3 doses

FIGURE

Duration: single dose or 1 to 3 days depending on clinical progress

Contra-indications, side-effects, precautions

- Do not administer to children under 2 years.
- Risk of drowsiness, use with care when driving.
- Risk of increased sedation when combined with alcohol and other drugs that act on the central nervous system: diazepam (Valium(R)), phenobarbitone (Gardenal(R)) and chlorpromazine (Largactil(R)).
- Avoid alcoholic drink during the treatment.
- Pregnancy: avoid
- Lactation : avoid

Remarks

- Dexchlorpheniramine (Polaramine(R) has the same indications but: 2 mg of dexchlorpheniramine has the same effect as 4 mg of chlorpheniramine.
- Storage: keep below 30°C

CHLORPROMAZINE (Largactil(R).)

District hospital

Therapeutic action

- Sedative neuroleptic
- Major tranquillizer

Indications PRESCRIPTIONS AND FOLLOW-UP TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Acute psychosis with agitation
- Chronic psychosis, hallucinations and schizophrenia

Preparation

- Tablet of 25 mg

There are also tablets of 50 and 100 mg. Adapt dosage accordingly.

Dosage

Varies from one person to another, doses have to be progressive.

- Child: 1.5 mg/kg/d divided in 3 doses
- Adult: 50 to 100 mg/d divided in 3 doses

FIGURE

- Do not exceed indicated doses.
- Lower the dose for elderly patients.

Duration: depending on clinical progress

Contra-indications, side-effects, precautions

- Do not administer in cases of:

· barbiturate or alcoholic coma,
· Parkinson's disease,
· renal or liver failure (risk of overdose).

- If patient becomes febrile, interrupt the treatment. It could be a case of malicious neuroleptic syndrome.
- Risk of extrapyramidal manifestations, orthostatic hypotension and photosensitization to the sun.
- Refer in case of acute intoxication.
- If prolonged treatment, check blood regularly (risk of agranulocytosis).
- Risk of sedation when combined with alcohol and other drugs that act on the central nervous system: diazepam (Valium(R)), phenobarbitone (Gardenal(R) and chlorpheniramine (Teldvin(R)).
- Pregnancy: CONTRA-INDICATED (in case of psychosis, stop treatment one week before delivery if possible)
- Lactation: avoid

Remarks

- Storage: keep below 30°C

CIMETIDINE (Tagamet(R).)

District hospital

Therapeutic action

- Healing of ulcers

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Active duodenal and gastric ulcers and prevention of relapses.
- esophagitis caused by gastro-esophageal reflux unresponsive to other treatments.

Preparation

- Tablets of 200 mg, 400 mg and 800 mg

Dosage

- Newborn and child: 10 to 20 mg/kg/d divided in 4 to 6 doses
- Adult :800 mg/d once daily (evening)

FIGURE

Duration :4 to 6 weeks

Contra-indications, side-effects, precautions

- Do not administer treatments over long periods.
- Do not administer an antacid (aluminium hydroxide) for 2 hours before or after taking cimetidine.
- May cause: diarrhoea, dizziness, rash, fever.
- Association with other drugs not advised (phenytoine), or to be monitored (propanolol theophylline...).
- Reduce dosage in case of severe hepatic or renal failure.
- Pregnancy: CONTRA-INDICATED
- Lactation: CONTRA-INDICATED

Remarks

- To prevent relapses of duodenal ulcers, reduce the dosage by half.
- Expensive treatment.
- Storage: keep below 30°C

CLOFAZIMINE (Lamprene(R).)

Special department

Therapeutic action

- Antibacterial, active against the leprosy bacillus

Indications

- Multibacillary leprosy, in association to other "anti-leprosy" medication
- Leprotic reaction: erythema nodosum leprosum

Preparation

- Capsules of 50 mg and 100 mg

Dosage

According to national protocol. For information:

- Multibacillary leprosy: 300 mg once a month under surveillance and 50 mg/d taken by patient at home. Must be combined with rifampicin and dapsone.
- Leprotic reaction: 100 to 300 mg/d

Duration

- 6 months or 2 years depending on the type of leprosy.
- Leprotic reaction :3 months, then decrease dosage progressively.

Contra-indications, side-effects, precautions

- Do not administer doses of 300 mg/d or over for more than 3 months.
- Administer with care in cases of liver or renal failure.
- Occasionally causes nausea and/or abdominal cramps.
- Orange red colouring of the skin, mucosa and skin lesions, which continues a long time after the end of treatment.
- Orange colouring of the urine, faeces and secretions.
- Should be combined with other "antileprotics".
- Pregnancy: avoid (if necessary may be used under medical supervision)
- Lactation: avoid (if necessary may be used under medical supervision)

Remarks

- The action on the tuberculoid type is quite slow, about 2 to 6 weeks.
- Only prescribe "anti-leprotics" in the content of an organised leprosy program.
- Storage: no special precautions.

CLOXACILLIN (Orbenin(R).)

District hospital

Therapeutic action

- Antibacterial (antibiotic) of the penicillin group, acting specifically against penicillinase producing staphylococci

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE

UNDER MEDICAL SUPERVISION

- Staphylococci infections resistant to other antibiotics: chronic osteomyelitis, pulmonary staphylococci of the newborn.

Preparation - Capsules of 250 mg and 500 mg

Dosage

- Child: 50 mg/kg/d divided in 3 doses
- Adult: 1 to 2 g/d divided in 3 doses
- In case of a severe infection, the dose can be doubled.

FIGURE

Duration: minimum 7 days

Contra-indications, side-effects, precautions

- Do not administer if known allergy to penicillin.
- If allergic reactions, stop treatment and refer to a doctor.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Cloxacillin, oxacillin and dicloxacillin are equivalent products: same indications and same doses, except for dicloxacillin (25 mg/kg/day).
- Storage: keep cool if possible

COTRIMOXAZOLE = Sulfamethoxazole (SMX) + Trimethoprim (TMP) (Bactrim(R), Cotrim(R), Eusaprim(R), Septrim(R).)

Health post

Therapeutic action

- Combination of 2 antibacterials including a sulfonamide (active during maximum 12 hours)

Indications

- Respiratory infections with fever
- Urinary infections
- Bacillary dysentery
- Otitis
- Gonorrhoea

Preparation

- Tablet of 400 mg sulfamethoxazole (SMX) + 80 mg trimethoprim (TMP)
- Syrup of 200 mg SMX + 40 mg TMP / 5 ml = 1 teaspoon

There are also tablets of 800 mg SMX + 160 mg TMP (named cotrimoxazole "forte") and paediatric tablets of 100 mg SMX + 20 mg TMP. Adapt dose accordingly.

Dosage

- Child : 1/2 to 2 tab of 400 mg + 80 mg/kg/d divided in 2 doses
- Adult: 4 tab of 400 mg + 80 mg/d divided in 2 doses

FIGURE

- To treat:

· gonorrhoea: 10 tabs of 400 mg + 80 mg/d once daily for 3 days
· urinary infections: 4 tabs of 400 mg + 80 mg in a single dose

- In case of acute respiratory infections in children under 5 years, double the dose:

· from 2 months to 1 year: 1/2 tab x 2
· from 1 to 5 years : 1 tab x 2

Duration: minimum 5 days

Contra-indications, side-effects, precautions

- Do not administer to children under 2 months.
- Frequent digestive problems.
- Allergic reactions mostly benign but sometimes severe (generalised bullous eruptions, agranulocytosis). In this case, stop treatment and refer to a doctor.
- Do not combine with other antibacterials.
- Drink a lot of liquid during treatment.
- Pregnancy: CONTRA-INDICATED
- Lactation: CONTRA-INDICATED

Remarks

- Storage: no special precautions.

Once prepared, the syrup can be kept for up to 1 week if kept cool.

DAPSONE (Avlosulfon(R).)

Special department

Therapeutic action

- Antibacterial, active against the leprosy bacillus

Indications

- Leprosy, in association to other "anti-leprosy" medication

Preparation

- Tablets of 50 mg and 100 mg

There are different strengths. Adapt dosage accordingly.

Dosage

According to national protocol.

For information:

- Child : 1 to 2 mg/kg/d once daily
- Adult: 100 mg/d once daily

FIGURE

Duration

- Multibacillary leprosy: 2 years or more, depending on the progress
- Paucibacillary leprosy: 6 months

Contra-indications, side-effects, precautions

- Do not administer if allergy or intolerance to sulfonamides.
- Avoid in case of liver failure.
- If severe anaemia or leucopenia develops, stop treatment and replace dapsone with another "antileprotic".
- Pregnancy: avoid (if necessary may be used under medical supervision)
- Lactation: avoid (if necessary may be used under medical supervision)

Remarks

- Warning: antileprotic treatment should only be prescribed in the context of an organised program.
- Dapsone should not be used alone, but in combination with other "antileprotic" drugs to avoid development of resistance.
- Storage: keep below 30°C

DIAZEPAM (Tensium(R), Valium(R).)

District hospital

Therapeutic action

- Anxiolytic
- Anticonvulsive, muscle relaxant

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Muscular contractions
- Agitation and anxiety

Preparation

-Tablet of 5 mg

There are also tablets of 2 mg and 10 mg. Adapt dosage accordingly.

Dosage

- Child: 0.5 mg/kg/d divided in 3 doses
- Adult: 5 to 15 mg/d divided in 3 doses

FIGURE

- Do not exceed indicated doses.
- Signs of overdose: muscular weakness, ataxia.
- Signs of intoxication (5 times the therapeutic dose): hypothermic coma.
- The dose should be halved for elderly patients.
- Should only be used exceptionally and with great care for children.

Duration: depending on clinical progress

Contra-indications, side-effects, precautions.

- Do not administer in cases of respiratory depression.
- Risk of drowsiness, use with care when driving.
- Addiction will occur in case of prolonged use (average 12 days). Reduce the dosage gradually to wean the patient off the drug.
- Risk of causing sedation when combined with alcohol and other drugs that act on the central nervous system: chlorpromazine (Largactil(R)), phenobarbitone (Gardenal(R)) and chlorpheniramine (Teldvin(R)).
- Pregnancy: avoid
- Lactation :avoid

Remarks

- Do not use as an easy remedy.
- Storage: no special precautions

DIETHYLCARBAMAZINE (Banacide(R), Hetrazan(R), Notezine(R).)

Special department

Therapeutic action

- Filaricide

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Lymphatic filariasis (Wuchereria bancrofti)
- Onchocerciasis (Onchocerca volvulus)
- Loiasis (Loa-loa)

Preparation

- Tablets of 50 mg and 100 mg

Dosage

According to national protocol.

For information:

- Lymphatic filariasis and onchocerciasis

· Child : build up dose progressively (over 4 days) 6 mg/kg/d divided in 2 doses
· Adult: build up dose progressively (over 4 days) 400 mg/d divided in 2 doses start the first day with 25 to 50 mg divided in 2 doses

- Loiasis
Adapt dosage to the parasite-load of the patient

· Child and adult: build up progressively (over 5 to 8 days) to 6 mg/kg/d divided in 2 doses start the first day with 3 mg/kg/d divided in 2 doses

- In West Africa, every treatment should start with 3 mg/d because of the risk of possible combination of loiasis with other filariasis.

Duration: 21 days

Contra-indications, side-effects, precautions

- Allergic reactions: pruritus, Iymphangitis, risk of shock due to the microfilaria lysis
(loiasis and onchocerciasis).
- Risk of lethal encephalitis; reactions are the most severe when the progressive protocol is not respected.
- Drowsiness, malaise, headache, nausea, vomiting.
- To prevent or decrease allergic reactions, administration of antihistamines is recommended.
- Pregnancy: avoid (in most cases, the treatment can wait until the end of the pregnancy)
- Lactation: avoid

Remarks - To treat onchocerciasis: ivermectin (Mectizan(R)), a single dose medication which is better tolerated, replaces diethylcarbamazine.

- An individual chemoprophylaxis against Loa-Loa is possible :100 mg once weekly.
- Storage: keep below 30°C

DIGOXIN (Lanoxin(R).)

District hospital

Therapeutic action

- Cardiotonic (reinforces the cardiac contraction, slows down and regulates the cardiac rhythm)

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Congestive heart failure, sinus arrhythmia (fibrillation, flutter, paroxysmal tachycardia) DIAGNOSED BY A DOCTOR.

Preparation

- Tablet of 0.25 mg (= 250 microgram = 250 mcg = 250 ug)

Dosage

- Child

· initial dose : 0.015 mg/kg (= 15 mcg/kg) x 3 to 4 doses the first day
· maintenance dose: 0.015 mg/kg/d once daily, 5 days in every 7

- Adult

· initial dose : 0.5 to 1 mg/d divided in 3 or 4 doses the first day
· maintenance dose: 0.25 mg/d divided in 1 or 2 doses, 5 days in every 7

Duration: depending on clinical progress

Contra-indications, side-effects, precautions

- Do not administer in cases of:

· bradycardia
· ill-defined heart rhythm disorders

- The surveillance of the pulse is vital at the beginning of the treatment.
- The therapeutic dose is near the toxic dose.
- Signs of overdose: digestive problems, visual problems, disorientation or confusion, arrythmia and problems of the atrio-ventricular conduction. In this case, reduce dosage or stop treatment. Nausea or vomiting are early signs of overdose.
- Higher risk of intoxication in cases of hypokalemia, especially if combined with a diuretic.
- Administer with care in cases of renal failure.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Storage: no special temperature requirements

ERYTHROMYCIN (Erythrocin(R), Ilotycin(R).)

District hospital

Therapeutic action

- Antibacterial (antibiotic)

Indications

- For upper and lower respiratory infections as a second choice and in case of allergy or resistance to penicillin

Preparation

- Tablets of 250 mg and 500 mg erythromycin (base)

Dosage

- Child : 30 to 50 mg/kg/d divided in 2 doses
- Adult: 1 to 3 g/d divided in 2 doses depending on the degree of infection
- In case of severe infections, it is recommended to give the dosage in 3 doses/day.

FIGURE

Duration: minimum 5 days

Contra-indications, side-effects, precautions

- Do not combine with ergotamine or aminophylline, especially in pediatrics.
- Allergic reactions, digestive problems possible.
- Administer with care in cases of liver failure.
- Transitory deafness at high doses.
- Pregnancy: no contra-indicafion
- Lactation: no contra-indication

Remarks

- Take before meals.
- Storage: no special precautions

ETHAMBUTOL (Myambutol(R).)

Special department

Therapeutic action

- "Antituberculous" antibacterial

Indications

- Only for tuberculosis, bacteriologically proven if possible

Preparation

- Tablets of 100 mg and 400 mg

There are also tablets of 250 mg and 500 mg. Adapt dosage accordingly.

Dosage

According to national protocol.

For information:

- Child above 5 years and adult: 20 mg/kg/d once daily

FIGURE

Duration: according to national protocol

Contra-indications, side-effects, precautions

- Do not administer in cases of severe renal failure or ocular disease.
- In case of inflammation of the optic nerve (problems of vision: colour and acuity), stop treatment and refer to a doctor.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Not recommended for children as the visual problems are hard to identify.
- Take in the morning before meal.
- Warning: antituberculous treatment should only be prescribed in the context of an organised program (well established protocol, regular patient checks and the possibility of laboratory examination).
- Ethambutol should not be used alone, but in combination with other "antituberculous" drugs to avoid development of resistance.
- Storage: no special precautions

Iron salts = FERROUS salts, fumarate, ascorbate, sulphate= FERROUS sulphate

Health post

Therapeutic action

- Essential to produce red blood cells

Indications

- Prevention of anaemia during pregnancy
- Treatment of anaemia due to lack of iron: insufficient intake, intestinal parasitic disease, blood loss

Preparation

- Tablet of 200 mg ferrous sulphate (containing 60 mg of the element iron)
Also available in different strengths. Adapt dosage accordingly.

Dosage (unit is ferrous salts)

- Prevention:

Child :6 mg/kg/d once daily
Pregnant women: 100 to 200 mg/d once daily

- Treatment :

Child: 15 to 30 mg/kg/d divided in 3 doses
Adult: 800 mg to 1.2 g/d divided in 3 doses

FIGURE

- Do not exceed indicated doses. Toxic dose: 100 mg/kg ferrous sulphate (= 30 mg/kg element iron).
- Signs of overdose: diarrhoea with blood, heart failure.

Duration

- Prevention: throughout the risk period (pregnancy, malnutrition)
- Treatment: 2 months minimum

Contra-indications, side-effects, precautions

- Do not combine with tetracycline as each drug prevents the other from being absorbed properly.
- Do not administer in cases of sickle cell anaemia.
- Can cause gastro-intestinal problems: gastric burning, diarrhoea or constipation.
- Black colouring of the stools.
- Do not exceed the recommended dose, especially in children.
- Pregnancy: no contra-indication (recommended to avoid anaemia)
- Lactation: no contra-indication

Remarks

- Take during meals to avoid digestive problems.
- If treatment requires the administration of ferrous salts, tablets containing both ferrous salts and folic acid are recommended.
- All ferrous salts are to be used in the same dose, e.g. ferrous fumarate, ascorbate
- Storage: no special precautions

FOLIC ACID

District hospital

Therapeutic action

- Vitamin necessary to produce red blood cells

Indications

- Anaemia caused by lack of folic acid: severe malnutrition, repeated attacks of malaria, intestinal parasites

Preparation

- Tablet of 5 mg. There are also tablets of 1 mg. Adapt dosage accordingly.

Dosage

- Child : 5 to 15 mg/d once daily
- Adult: 10 to 20 mg/d once daily
- In case of severe anaemia, it is recommended to double.

FIGURE

Duration :15 to 30 days

Contra-indications, side-effects, precautions

- Well tolerated.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Storage: no special temperature requirements

FERROUS Salt + FOLIC ACID (Fegal(R).)

Indications

- Prevention of lack of iron and folic acid, mainly during pregnancy

Preparation

- Tablet of 200 mg ferrous sulphate and 0.25 mg folic acid

Dosage

- Child: 1 tab/d
- Adult: 1 to 2 tab/d

Remarks

- This combination is not suitable for the treatment of folic acid deficiency because of its low dose (0.25 mg).
- Storage: keep below 30°C

FUROSEMIDE = FRUSEMIDE (Frusid(R)), Lasix(R).)

District hospital

Therapeutic action

- Diuretic

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Oedema caused by renal, heart or liver failure, DIAGNOSED BY A DOCTOR

Preparation

- Tablet of 40 mg

Dosage

- Child: 0.5 to 1 mg/kg/d once daily
- Adult: 20 to 80 mg/d once daily

FIGURE

Duration: depending on clinical progress

Contra-indications, side-effects, precautions

- Never administer for other types of oedema, particularly not for kwashiorkor.
- Risk of hypokalemia (increases the toxicity of digoxin when used together).
- Pregnancy:avoid
- Lactation: no contra-indication (but can reduce the milk production)

Remarks

- A lot of fruit should be eaten during the treatment (dates, bananas, tomatoes, mangos, oranges.), in order to supply additional potassium. Use potassium tablets as well if available.
- Storage: no special temperature requirements

GRISEOFULVIN (Fulcin(R), Grisavin(R).)

District hospital

Therapeutic action

- Antifungal

Indications

- Dermatophytosis: fungal infections of skin, scalp and nails (tinea)

Preparation

- Tablets of 125 mg and 500 mg

Dosage

- Child : 10 mg/kg/d divided in 2 doses
- Adult : 500 mg to 1 g/d divided in 2 doses

For scalp infection, there is a single dose treatment

- Child and adult :1.5 g in a single dose (3 tabs of 500 mg or 12 tabs of 125 mg). In this case, the administration of a spoonful of oil improves the effectiveness of the treatment.

FIGURE

Duration - Depending on clinical progress, minimum 10 days. Often needs to be extended over 1 month.

Contra-indications, side-effects, precautions

- Do not administer in cases of liver failure.
- May cause: frequent vomiting, diarrhea, stomach-ache, headache, dizziness, skin allergy and photosensitization, especially with the single dose treatment.
- Do not drink alcohol during treatment.
- Pregnancy: CONTRA-INDICATED
- Lactation: CONTRA-INDICATED

Remarks

- Use gentian violet to dry the lesions.
- Has no effect on candidiasis or pityriasis versicolor.
- Storage: no special temperature requirements.

HALOFANTRINE (Halfan(R).)

The use of this drug is not advised:

- it is potentially dangerous; these severe adverse effects concerning the cardiac conductions are unforeseable even if an ECG has been done previously;
- it is not included in the WHO essential drug list;
- it is expensive.

Therapeutic action

- Antimalarial

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Curative treatment of a malaria attack with Plasmodium falciparum resistant to chloroquine.

Preparation

- Tablet of 250 mg
- Oral suspension 45 ml to 20 mg/ml (1 measuring spoon=1 m.s. = 5 ml = 100 mg)

Dosage

- Child and adult: 24 mg/kg divided in 3 doses to be taken every 6 hours
- Do not exceed indicated doses

FIGURE

Duration: 3 doses, taken every 6 hours

Contra-indications, side-effects, precautions

- Do not administer in case of congenital or acquired prolonged QT interval of the electrocardiogram.
- Avoid in case of severe electrolytic disorders and in thiamin (vitamin B1) deficiency.
- Do not associate with drugs predisposing to the occurrence of "torsades de pointes": antiarrhythmic drugs (quinidine, disopyramide, sotalol), drugs inducing hypokaliemia (diuretics, glucocorticoids).
- May induce arrhythmias: prolongation of QT interval and severe, eventually fatal, ventricular arrhythmias ("torsades de pointes").
- May cause diarrhoea (occasionally), abdominal pain, nausea and vomiting.
- Do an ECG before giving the treatment in case of history of unexplained syncope or malaise.
- Pregnancy: CONTRA-INDICATED
- Lactancy: CONTRA-INDICATED

Remarks

- Administer away from the meals.
- The QT prolongation is more marqued in case of recent treatment with mefloquine.
- Do not use as a preventive treatment because of rapid elimination.
- If the patient has not had a previous malaria attack repeat the treatment after one week.
- Since this treatment is expensive, and to avoid emergence of resistant strains, use, instead sulfadoxine-pyrimethamine or quinine if possible, depending on the local situation and protocol.
- Storage:

HYDRALAZINE (Apresoline(R).) and DIHYDRALAZINE (Nepressol(R).)

District hospital

Therapeutic action

- Antihypertensive drug with vasodilatory action

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Moderate or severe arterial hypertension when thiazide diuretics or beta-blockers on their own are ineffective

Preparation

- Tablets of 25 mg and 50 mg

Dosage

- Initial dose: adult: 25 to 50 mg/d divided in 2 or 3 doses
- Raise the dose progressively over 2 weeks until the optimal dose of 100 mg/d in 2 or 3 doses is reached.
- When the hypertension is under control, decrease the dose progressively. Stopping suddenly can provoke a hypertensive crisis.
- Do not exceed indicated doses. Maximum dose : 200 mg/d.

Duration: depending on clinical progress

Contra-indications, side-effects, precautions

- Do not administer in cases of coronary insufficiency or a recent myocardial infarction.
- Administer with care to elderly patients or those with a history of cerebrovascular accidents.
- Tachycardia reflex, headache.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Hydralazine and dihydralazine are used for the same indications at the same dosage.
- Storage: keep below 30°C

HYDROCHLOROTHIAZIDE (Dochlotride(R), Esidrex(R), HydroSaluric(R).)

District hospital

Therapeutic action

- Diuretic

Indications

- Moderate or severe arterial hypertension
- Oedema caused by renal, heart or liver failure, DIAGNOSED BY A DOCTOR

Preparation

- Tablet of 50 mg

There are also tablets of 25 mg. Adapt dosage accordingly.

Dosage

- Œdema

· Child : 1 mg/kg/d divided in 2 doses
· Adult: 50 to 100 mg in the morning, every 2 days

- Hypertension

· Adult: 25 to 50 mg/d divided in 2 doses

FIGURE

Duration: depending on clinical progress

Contra-indications, side-effects, precautions

- Do not administer in cases of severe renal failure, allergy to sulfonamides or kwashiorkor oedema.
- May cause: orthostatic hypotension, photosensitization, disturbance of electrolytes, skin allergies.
- Pregnancy: CONTRA-INDICATED
- Lactation: CONTRA-INDICATED

Remarks

- Often used in association with other antihypertensive drugs.
- A lot of fruit should be eaten during the treatment (dates, bananas, tomatoes, mangos, oranges.), in order to supply additional potassium. Use potassium tablets as well if available.
- Storage: no special temperature requirements

IBUPROFEN (Brufen(R), Fenbid(R), Motrin(R).)

District hospital

Therapeutic action

- Non-steroidal anti-inflammatory
- Analgesic, antipyretic

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISlON

- Rheumatic diseases

Preparation

- Tablets of 200 mg and 400 mg

Dosage

- Adult: 1200 mg/d divided in 3 doses
- A dose of 2400 mg/d may be used at the beginning of treatment of rheumatoid arthritis.

FIGURE

Duration: depending on clinical progress

Contra-indications, side-effects, precautions

- Do not administer in cases of gastroduodenal ulcer and severe renal or liver failure.
- Do not prescribe for children.
- May cause: gastrointestinal problems, allergic reactions.
- Do not combine with other anti-inflammatory drugs (aspirin, indometacin).
- Use with care for infectious diseases: can mask the usual symptoms of the infection.
- Pregnancy: CONTRA-INDICATED
- Lactation: CONTRA-INDICATED

Remarks

- Take with meals.
- Ibuprofen has less anti-inflammatory activity than indometacin, but is better tolerated in the long term.
- Only prescribe for severe cases which do not improve by ASA (aspirin).
- Storage: no special precautions

INDOMETACIN (Artracin(R), Indocid(R).)

District hospital

Therapeutic action

- Non-steroidal anti-inflammatory drug
- Analgesic, antipyretic

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Rheumatic diseases
- Gout

Preparation

- Tablet of 25 mg

Dosage

- Adult :50 to 150 mg/d divided in 3 doses

FIGURE

Duration: depending on clinical progress

Contra-indications, side-effects, precautions

- Do not administer in cases of:

· gastroduodenal ulcer,
· severe renal or hepatic failure,
· asthma.

- Do not prescribe for children.
- May cause: headache, dizziness, digestive problems, gastric ulcer.
- Use with care for elderly patients.
- Do not combine with ASA (aspirin) and corticosteroids.
- Pregnancy :avoid
- Lactation :avoid

Remarks

- Take with meals.
- Only prescribe for severe cases which are not improving with ASA (aspirin).
- Storage: no special temperature requirements.

ISONIAZID = INH (Rimifon(R).)

Special department

Therapeutic action

- "Antituberculous" antibacterial

Indications

- Only for tuberculosis, bacteriologically proven if possible

Preparation

- Tablets of 100 mg, 150 mg and 300 mg

There are also tablets of isoniazide + rifampicine.

Dosage

According to national protocol.

For information:

- Child: 10 to 20 mg/kg/d once daily
- Adult: 5 mg/kg/d once daily

FIGURE

Duration: according to national protocol

Contra-indications, side-effects, precautions

- Do not administer in cases of liver failure or epilepsy.
- Do not combine with niridazole: severe mental problems.
- If the patient complains about a prickling feeling in the fingers and toes, or presents signs of liver intoxication (jaundice), stop the treatment and refer to a doctor.
- To avoid polyneuritis, give vitamin B6 with this treatment :10 to 25 mg/d.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Take in the morning before eating.
- Warning: antituberculous treatment should only be prescribed in the context of an organised program (well established protocol, regular patient checks and the possibility of laboratory examination).
- Isoniazid should not be used alone, but in combination with other "antituberculous" drugs to avoid development of resistance.
- Storage: no special temperature requirements

ISONIAZID + THIACETAZONE = INH + THIACETAZONE (Thiazine(R).)

Special department

Therapeutic action

- Combination of two "antituberculous" antibacterial drugs

Indications

- Only for tuberculosis, bacteriologically proven if possible

Preparation

- Tablets of 100 mg INH + 50 mg thiacetazone and 300 mg INH + 150 mg thiacetazone

Dosage

According to national protocol.

For information:

- Child: 10 to 20 mg/kg/d INH + 50 to 100 mg/d thiacetazone, once daily
- Adult: 5 mg/kg/d INH + 150 mg/d thiacetazone, once daily

FIGURE

Duration: according to national protocol.

Contra-indications, side-effects, precautions

- Do not administer in cases of liver failure or epilepsy.
- Do not combine with niridazole: severe mental problems.
- If the patient complains about a prickling feeling in the fingers and toes, or presents signs of liver intoxication (jaundice), stop the treatment and refer to a doctor.
- In case of intolerance to thiacetazone: skin reactions, haematological disorders, signs of haemolysis, reduction of polynuclear cells or cerebral oedema, stop treatment and refer to a doctor, even if reaction is only moderate.
- If available, give vitamin B6 with this treatment :10 to 25 mg/d.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Take in the morning before eating.
- Warning: antituberculous treatment should only be prescribed in the context of an organised program (well established protocol, regular patient checks and the possibility of laboratory examination).
- Intolerance to thiacetazone varies genetically, and is notably more common in Asia.
- Warning: thiacetazone is not vitamin B1.
- At the beginning of treatment, INH + thiacetazone should be accompanied by another "antituberculous" drug.
- Storage: no special temperature requirements.

IVERMECTIN (Mectizan(R).)

Special department

Therapeutic action

- Antifilaria

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Onchocerciasis with O. volvulus

Preparation

- Divisible tablet of 6 mg

Dosage

- Child and adult :150 to 200 microgrammes/kg (= 0.200 mg/kg), single dose, to be taken on an empty stomach

FIGURE

Duration: single dose

Contra-indications, side-effects, precautions

- Do not administer to children under 5 years.
- May cause passing allergic reactions: pruritus, lymphangitis, fever, œdema, tachycardia, drowsiness.
- Mild, passing digestive problems.
- Benign ophthalmic effects.
- Do not eat within 2 hours after taking the medicine.
- Pregnancy: avoid during first trimester
- Lactation: avoid until the breastfed infant is 3 months of age.

Remarks

- Ivermectin is much better tolerated than diethylcarbamazine in the treatment of onchocerciasis.
- Ivermectin is given free of charge by the manufacturer as part of the campaign against onchocerciasis.
- Storage: no special precaution

LEVAMISOLE (Tramisol(R).)

Health clinic

Therapeutic action

- Anthelminthic

Indications

- Ascariasis
- Hookworm (ankylostomiasis)

Preparation

- Tablet of 40 mg and 150 mg levamisole (base)

Dosage

Child and adult: 2.5 mg/kg

FIGURE

Duration

- Ascariasis : single dose
- Hookworm: repeat treatment after 7 days

Contra-indications, side-effects, precautions

- May cause: nausea, vomiting.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Effectiveness in treatment of hookworm is 75 to 95%.
- Advice on sanitation should be given with the treatment.
- Storage: no special precautions

LOPERAMIDE (Imodium(R), Inosec(R).)

District hospital

Therapeutic action

- Antidiarrhoeal

Indications

- Symptomatic treatment of persistent diarrhoeas, primarily for adults with AIDS, with rehydration.

Preparation

- Capsule of 2 mg

Dosage

- Adult: 2 cap at once, then 1 cap 1 to 3 times per day
- Maximum dosage :8 cap/d

Duration: depending on clinical progress

Contra-indications, side-effects, precautions

- Do not administer to children.
- Risk of constipation.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- The classical treatment of diarrhoea is based on oral rehydration. It is also possible to associate a treatment with traditional herbs (for example infusions of guava leaves.). Loperamide is necessary only for AIDS-patients.
- Storage: keep below 30°C

MEBENDAZOLE (Vermox(R).)

Health post

Therapeutic action

- Anthelminthic

Indications

- Hookworm (ankylostomiasis)
- Ascariasis
- Enterobiasis (pinworm)
- (Tapeworms and strongyloidiasis: second choice)

Preparation

- Tablet of 100 mg

There are also tablets of 500 mg. Adapt dosage accordingly.

Dosage

- Child above 2 years and adult

· Hookworm : 200 mg/d divided in 2 doses for 3 days
· Ascariasis : 500 mg in a single dose
· Enterobiasis 100 mg in a single dose, repeat after 2 or 3 weeks

FIGURE

Duration

- Hookworm : 3 days
- Ascariasis : single dose
- Enterobiasis: single dose, repeat treatment after 2 or 3 weeks

Contra-indications, side-effects, precautions

- Do not administer to children under 2 years.
- Pregnancy: avoid (in most cases, the treatment can wait until the end of the pregnancy)
- Lactation: no contra-indication

Remarks

- In cases of endemic hookworm, it is recommended to prescribe at the same time an antianaemic treatment with ferrous sulphate (if possible combined with folic acid).
- For the systematic elimination of parasites, a single dose scheme of 600 mg can be used.
- Flubendazole has the same indications and dosage.
- Albendazole (Zentel(R)) has the same indications and dosage as mebendazole: 400 mg (2 tab of 200 mg), single dose.
- Advice on sanitation should be given with the treatment.
- Storage: no special precautions

MEFLOQUINE (Lariam(R).)

District hospital

Therapeutic action

- Antimalarial

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Curative treatment of a malaria attack with Plasmodium falciparum resistant to chloroquine.

Preparation

- Divisible tablet of 250 mg
- Tablet of 50 mg

FIGURE

Dosage

- Curative treatment :25 mg/kg (person with no immunity)
- Preventive treatment for travellers with no immunity in areas with resistance to chloroquine: 4 mg/kg/week

A weekly dose is necessary: start 1 week before departure and continue for one month after return. Do not take during more than 15 weeks.

Contra-indications, side-effects, precautions

- Not advised for children under 15 kg.
- Digestive problems, dizziness, headache.
- May cause neuropsychopathic problems at curative dosage.
- Bedrest under medical supervision for 24 hours after treatment.
- Do not use at the same time as quinine.
- Pregnancy: CONTRA-INDICATED
- Lactation: avoid

Remarks

- Because of the secondary reactions, the cost of the treatment, and to avoid the spread of resistance, treatment with mefloquine is prescribed as a last resort. Use, instead, sulfadoxine-pyrimethamine or quinine, depending on the local situation and protocol.
- Storage: keep below 30°C

METAMIZOL = DIPYRONE = NORAMIDOPYRINE (Nolotil(R), Novalgin(R), Novaminsulfon(R).)

The use of this drug is not advised:

- it is potentially dangerous;
- it is not included in the WHO essential drug list;
- its marketing is forbidden in several countries;
- its use is never justified as a first-line treatment.

Therapeutic action

- Analgesic
- Antipyretic

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Severe pains
- High fever

Preparation

- Tablet of 500 mg

Dosage

- Child (above 5 years): 250 mg to 1 g/d divided in 3 doses
- Adult: 500 mg to 3 g/d divided in 3 doses

FIGURE

Duration: depending on clinical progress, 1 to 3 days

Contra-indications, side-effects, precautions

- Do not administer in cases of gastric ulcer.
- Severe and lethal cases of agranulocytosis have been found. Use only when other antipyretics and analgesics (e.g. acetyl salicylic acid and paracetamol) are not effective.
- Pregnancy: avoid
- Lactation: avoid

Remarks

- Storage: no special precautions

METHYLDOPA (Aldomet(R), Medomet(R).)

District hospital

Therapeutic action

- Central acting antihypertensive drug without a diuretic effect

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Arterial hypertension if no improvement is seen using only diuretics or if beta-blockers are contra-indicated

Preparation

- Tablet of 250 mg

Dosage

- Child: 10 mg/kg/d divided in 3 doses
- Adult: 750 mg/d divided in 3 doses; may be increased progressively up to 1,500 mg/d
- Maximum dosage :2.5 g/d (10 tab)

FIGURE

Duration: depending on clinical progress

Contra-indications, side-effects, precautions

- Do not administer in cases of:

· angina pectoris,
· renal or liver failure,
· depression.

- May cause: orthostatic hypotension, dry mouth, sedation, mental or hormonal problems.
- Don't stop the treatment suddenly; reduce the daily doses progressively.
- Pregnancy: no contra-indication
- Lactation: avoid

Remarks

- Storage: keep below 30°C

METOCLOPRAMIDE (Anausin(R), Maxolon(R), Primperan(R), Reglan(R).)

District hospital

Therapeutic action

- Anti-emetic

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Vomiting
- Nausea
- Hiccups

Preparation

- Tablet of 10 mg

Dosage

- Newborn: 0.5 mg/kg/d divided in 3 doses
- Child : 0.3 to 0.4 mg/kg/d divided in 3 doses
- Adult : 5 to 10 mg/kg/d divided in 3 doses

FIGURE

Duration: depending on clinical progress, as short as possible

Contra-indications, side-effects, precautions

- Contra-indicated in case of haemorrhage, gastro-intestinal obstruction or perforation.
- When elevated doses are given or when treatments are prolonged, extrapyramidal disorder can occur (agitation and spasms), specially in young patients.
- Increased risk of crisis with epileptics and those suffering from Parkinson's disease.
- Reversible methaemoglobinemia in newborns.
- Association with propantheline, hyoscine, atropine and chlorpromazine is not advised.
- Risk of drowsiness.
- Pregnancy: no contra-indication
- Lactation: avoid

Remarks

- It is most important to treat the cause of vomiting; look for bowel obstruction or malaria.
- Storage: keep below 30°C

METRIFONATE (Bilarcil(R))

Special department

Therapeutic action

- Schistosomicide

Indications

- Urinary bilharzia (Schistosoma haematobium)

Preparation

- Tablet of 100 mg

Dosage

- Child : 10 mg/kg in a single dose
- Adult: 400 mg in a single dose; if the weight of the patient is known, adapt dosage (10 mg/kg)
- Do not exceed indicated doses.

FIGURE

Duration: single dose

Contra-indications, side-effects, precautions

- Risk of overdose: abdominal cramps, bronchospasms, sweating, salivation. In this case, inject an ampoule of atropine SC or inject slowly intravenously.
- Pregnancy: avoid (in most cases the treatment can wait until the end of the pregnancy)
- Lactation: avoid

Remarks

- Repeat treatment after 15 days if the patient leaves the endemic area.
- This drug should be preferred to niridazole (Ambilhar(R)). Niridazole is more expensive and less well tolerated.
- In an endemic area, antibilharzia treatment will only be effective if preventive measures exist to avoid continuous reinfection.
- Advice on sanitation should be given with the treatment.
- Storage: keep below 30°C

METRONIDAZOLE (Flagyl(R)), Metrolyl(R), Zadstat(R).)

Health clinic

Therapeutic action

- Anti-protozoal, antibacterial

Indications

- Amoebiasis, trichomoniasis, giardiasis (= lambliasis)
- Certain anaerobic infections (Bacteroides fragilis, Clostridium perfringens)

Preparation

- Tablet of 250 mg

There are also tablets of 200 mg. Adapt dosage accordingly.

Dosage

- Amoebic dysentery:

Child: 30 to 50 mg/kg/d divided in 3 doses
Adult: 1.5 g/d divided in 3 doses

- Giardiasis:

Child : 15 mg/kg/d divided in 3 doses
Adult: 750 mg/d divided in 3 doses

- Trichomoniasis :

Adult: 2 g in a single dose

- Metronidazole can be used as an antibiotic, under medical supervision, with the same dose used for amoebiasis treatment and combined with penicillin or ampicillin for 6 to 10 days.

FIGURE

Duration

- Amoebic dysentery: 7 days
- Giardiasis : 7 days; repeat treatment after one week
- Trichomoniasis : single dose

Contra-indications, side-effects, precautions

- May cause digestive problems.
- Do not drink alcohol during treatment.
- Pregnancy: a teratogenic effect is not proven, Metronidazole treatment is possible in pregnant woman and it is justified to treat amoebiasis with clinical signs. Nevertheless, try to avoid in the first trimester of pregnancy.
- Lactation: avoid (passes into the breast milk)

Remarks

- In case of trichomoniasis, the partner has to receive oral treatment as well.
- The metronidazole pessaries are not recommended for vaginal trichomoniasis. Treatment should be oral.
- The mere presence of amoeba cysts in the stools is not a sufficient reason to administer metronidazole.
- In mass-treatment of amoebiasis, single dose treatment can be used:

· child: 4 tab from 5 to 15 years; 2 tabs from 1 to 5 years; 1 tab from 1 month to 1 year
· adult: 8 tab (in case of vomiting, give in 2 doses/day)

- Storage: keep below 30°C

MULTIVITAMINS VITAMIN B COMPLEX

Health post

Therapeutic action

- Vitamin supplement

Indications

- Only a few indications: this drug has no effect in cases of real vitamin deficiency, but it will help prevent deficiency in people at risk (pregnant women, malnourished persons).

Preparation

- Tablet and syrup

Composition of tablets varies in quality and quantity, depending on the manufacturer.

Example of composition per tablet(1):

	Multivitamins	B complex	Daily needs - adult
Vitamin A	2.500 IU	/	2.500 IU
Vitamin B1	1 mg	2 mg	0.9 to 1.3 mg
Vitamin B2	0.5 mg	1 mg	1.5 to 1.8 mg
Vitamin B3 (= PP)	7.5 mg	15 mg	1.5 to 20 mg
Vitamin C	15 mg	/	10 mg
Vitamin D3	300 IU	/	100 to 200 IU

(1) IDA catalogue, 1991

Dosage

- Child and adult: see table below

FIGURE

Duration: depending on situation

Contra-indications, side-effects, precautions

- Pregnancy: no contra-indicafion
- Lactation: no contra-indication

Remarks

- This drug has no impact on sexual activity.
- Multivitamins can be used as a placebo as they are both safe and inexpensive. Their composition is generally similar to the preventive treatment of avitaminoses and has no contra-indication.
- It is not included in the WHO Essential drug list.
- Storage: keep cool if posible.

NICLOSAMIDE (Tredemine(R), Yomesan(R).)

Health clinic

Therapeutic action

- Anthelminthic

Indications

- Tapeworms: Taenia saginata (beef), Taenia solium (pork), Hymenolepsis nana

Preparation

- Tablet of 500 mg

Dosage

- Taenia saginata and Taenia solium

· Child: 30 mg/kg in a single dose, on an empty stomach
· Adult: 2 g in a single dose, on an empty stomach

- Hymenolepsis nana

· Child: 30 mg/kg once daily for 5 days
· Adult: 2 g once daily the first day, then 1 g/d for 6 days

FIGURE

Duration

- Taenia saginata and Taenia solium: single dose
- Hymenolepsis nana : 7 days

Contra-indications, side-effects, precautions

- Frequent digestive problems (stomach pain).
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- The evening before, take a liquid meal. Take the drug in the morning before eating. CHEW THE TABLETS WELL. WAIT TWO HOURS BEFORE TAKING FOOD.
- In case of vomiting, the single dose treatment should be split into two doses, taken with an interval of one hour.
- Niclosamide kills the worm. You do not have to wait to see the worm complete in the stools because it is killed and partially digested.
- Advice on sanitation should be given with the treatment.
- Storage: no special temperature requirements.

NITROFURANTOIN (Furandantin(R), Urantoin(R).)

District hospital

Therapeutic action

- Antibacterial

Indications

- Infections without complications of the lower urinary tract (without fever or lumbar pain).

Do not confuse with gonorrhea (urethral discharge in the morning)

Preparation

- Tablets of 50 mg and 100 mg

Dosage

- Child (above one year): 5 mg/kg/d divided in 3 doses
- Adult: 300 mg/d divided in 3 doses

FIGURE

Duration: minimum 10 days

Contra-indications, side-effects, precautions

- Do not administer to children under 1 year.
- Do not administer in cases of renal failure.
- Dizziness can be a side-effect: stop treatment immediately and refer to a doctor.
- Do not drink alcohol during the treatment.
- Pregnancy: CONTRA-INDICATED at the end of the pregnancy
- Lactation :avoid

Remarks

- If possible, take with meals.
- Cotrimoxazole is generally more active in cases of urinary infections.
- Storage: no special temperature requirements.

NOSCAPINE

District hospital

Therapeutic action

- Antitussive

Indications

- Dry cough

Preparation

- Tablet of 15 mg
- Syrup of 15 mg/5 ml = 1 teaspoon

Dosage

- Child (above 30 months): 4 mg/kg/d divided in 3 doses
- Adult :45 to 90 mg/d divided in 3 doses
- Do not exceed indicated doses.

FIGURE

Duration: maximum 5 days

Contra-indications, side-effects, precautions

- Do not administer in cases of productive cough (sputum).
- Avoid using in children under 30 months.
- May cause: headache, constipation.
- Pregnancy:avoid
- Lactation: avoid

Remarks

- Using traditional anti-cough plants in the form of an infusion or syrup is often recommended.
- Codeine is a similar product with the same indications, but taken in smaller doses.
- Storage: no special precautions.

NYSTATIN (Mycostatin(R), Nystan(R).)

District hospital

Therapeutic action

- Antifungal: candidiasis

Indications

- Digestive candidiasis
- Candidiasis of the mucosa of the mouth and vagina

Preparation

- Tablet of 100,000 IU; for oral and gynaecological use

There are also tablets of 500,000 IU. Adapt dosage accordingly.

Dosage

- Digestive candidiasis Child and adult :4 to 5 tab/d to be sucked
- Candidiasis of the mouth. Child and adult: 1 to 2 tab/d to be sucked or put in the mouth after being crushed
- Vaginal candidiasis. Adult: 1 to 2 tab/d (wet the tablet before introducing it into the vagina)

Duration

- Candidiasis of the mouth: 8 to 10 days
- Vaginal candidiasis : 10 to 20 days

Contra-indications, side-effects, precautions

- The drug is well tolerated.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Has no effect on other types of fungi.
- Oral candidiasis can also be treated with the application of gentian violet or mouth washes with a base of lemon juice or sodium bicarbonate.
- THE GYNAECOLOGICAL TABLETS CAN ALSO BE USED FOR TREATMENT OF ORAL CANDIDIASIS.
- The tablets of 500,000 IU are meant to be swallowed (candidiasis of the digestive tube), but they can be sucked in case of oral candidiasis.
- For vaginal candidiasis, administer orally at the same time as vaginal applications. Do not interrupt treatment during menstruation. Sexual activity is not a contra-indication.
- Storage: keep below 30°C.

ORAL REHYDRATION SALT = ORS (Oralit(R).)

Health post

Therapeutic action

- Provide salts and sugar

Indications

- Prevention and treatment of dehydration in case of diarrhoea and/or vomiting

Preparation

- Sachet of powder to be diluted in one litre of clean, cooled boiled water

Composition:

· sodium chloride (NaCl) 3.5 g
· potassium chloride (KCl) 1.5 g total = 27.9 g
· trisodium citrate 2.9 g
· glucose (dextrose) 20.0 g

Dosage

According to national protocol.

For information:

- Child : 1 to 2 sachets/d given during the whole day = 1 to 2 litres
- Adult: 3 to 4 sachets/d given during the whole day = 3 to 4 litres
- Do not exceed indicated doses.

FIGURE

Duration: as long as the diarrhoea and signs of dehydration continue

Contra-indications, side-effects, precautions

- If oedema develops, reduce the quantities.
- In case of vomiting, give the liquid frequently in very small amounts; do not stop the rehydration.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- If the child cannot swallow, use a (naso-) gastric tube if necessary.
- Signs of improvement: the patient begins to urinate again.
- When the patient improves, you can give ORS and clean water alternately.
- If no ORS is available, you can use a sugar and salt solution: 2 pinches of salt (3 g), 4 tablespoons of sugar (40 go), added to some fruit juice, diluted in one litre of clean, cooled boiled water.
- Storage: no special temperature requirements. Do not use the powder if it has turned into a yellow-brown sticky substance.

ONCE MADE UP, THE SOLUTION MUST BE USED THE SAME DAY.

OXAMNIQUINE (Mansil(R), Vansil(R).)

Special department

Therapeutic action

- Schistosomicide

Indications

- Intestinal bilharzia (Schistosomia mansoni)

Preparation

- Tablet of 250 mg

Dosage

- Child : 20 to 40 mg/kg in a single dose
- Adult: 1 g in a single dose

FIGURE

Duration: single dose

Contra-indications, side-effects, precautions

- Do not administer in cases of renal or heart failure, or epilepsy.
- May cause: nausea, some dizziness, drowsiness, headache.
- Colours the urine red.
- Pregnancy: avoid (in most cases, treatment can wait until the end of the pregnancy)
- Lactation: avoid

Remarks

- Take with evening meal to avoid side-effects.
- Treatment with praziquantel, which is just as effective and well tolerated, and 3 times as cheap (IDA 1991).
- This drug is less dangerous than niridazole (Ambilhar(R)).
- The impact of the antibilharziosis treatment will be negligible if there are no parallel preventive measures to avoid the recurrence of the disease in endemic areas.
- Advice on sanitation should be given with the treatment.
- Storage: no special precautions

PARACETAMOL=ACETAMINOPHEN (Doliprane(R), Panadol(R), Tylenol(R).)

Health post

Therapeutic action

- Analgesic
- Antipyretic

Indications

- Headache, toothache or joint pain
- Fever

Preparation

- Tablets of 100 mg and 500 mg

Dosage

- Child : 20 to 30 mg/kg/d divided in 3 doses
- Adult: 2 to 3 g/d divided in 3 doses

FIGURE

Maximum doses:	Child: 50 mg/kg/d
	Adult: 4 g/d

Duration

- Depending on clinical progress, 1 to 3 days.
- Do not continue treatment for an extended period without medical advice.

Contra-indications, side-effects, precautions

- Do not administer in cases of liver disease (hepatitis) or alcoholism.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Paracetamol is recommended for patients who are allergic to A.S.A. (aspirin), those with stomach problems and for children under one year.
- IT HAS NO ANTI-INFLAMMATORY PROPERTIES.
- Storage: keep below 30°C.

PHENOBARBITONE = PHENOBARBITAL (Gardenal(R), Luminal(R).)

District hospital

Therapeutic action

- Anticonvulsive, sedative and hypnotic

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Epilepsy: tonic-clonic ("grand mal") and partial (focal) seizures

Preparation

- Tablets of 30 mg, 50 mg and 100 mg

Dosage

According to national protocol.

For information:

- Child : 3 to 5 mg/kg/d once daily or divided in 2 to 3 doses
- Adult: 150 to 200 mg/d once daily or divided in 2 to 3 doses

FIGURE

Duration: depending on clinical progress

Contra-indications, side-effects, precautions

- Do not administer in cases of respiratory depression or porphyria.
- Risk of drowsiness and depression of the central nervous system.
- Do not stop the treatment suddenly.
- Risk of sedation when combined with alcohol and other drugs that act on the central nervous system: diazepam (Valium(R), chlorpheniramine (Teldvin(R)) and chlorpromazine (Largactil(R)).
- Pregnancy:avoid
- Lactation: avoid

Remarks

- For convulsions, in cases of extreme agitation and in emergencies, it is better to use diazepam (Valium(R)).
- Plasma-concentrations are stable after 2 to 3 weeks. Beware of accumulation.
- If necessary, a treatment with phenytoin may be used with this treatment.
- Storage: no special precautions.

PHENOXYMETHYL PENICILLIN=PENICILLIN V (Crystapen V(R), Stabillin V-K(R), V-Cil-K(R).)

Health clinic

Therapeutic action

- Antibacterial (antibiotic)

Indications

- Tonsillitis
- Pneumopathy
- Dental abscess
- Extensive impetigo with or without general signs

Preparation

- Tablets of 125 mg (200,000 IU) and 250 mg (400,000 IU)
- Syrup of 125 mg/5 ml (200,000 IU/5 ml) = 1 teaspoon (1 tsp)

There are also other presentations and strengths. Adapt dosage accordingly.

Dosage

- Child: 150,000 IU/kg/d divided in 3 doses
- Adult: 1.5 to 3 MIU/d divided in 3 doses

4 doses/day are more effective, but to ensure that the treatment is likely to be followed correctly, we recommend 3 doses/day.

FIGURE

Duration :5 to 8 days

Contra-indications, side-effects, precautions

- Do not administer in cases of known allergy to penicillin.
- If allergic reactions: stop treatment and refer to a doctor.
- Do not combine with other antibiotics.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Do not use orally in case of:

· meningitis or gonorrhoea (use injections of procaine penicillin or PPF);
· syphilis (use injections of benzathine penicillin).

- Storage: keep below 30°C.

Once prepared, the syrup must be kept cool and will only last for one week.

PHENYLBUTAZONE (Butazolidin(R).)

The use of this drug is not advised:

- it is potentially dangerous;
- it is not included in the WHO essential drug list;
- its marketing is forbidden in several countries.

Therapeutic action

- Non steroidal anti-inflammatory

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Ankylosing spondilitis, gout, resistant to other anti-inflammatory drugs

Preparation

- Tablet of 200 mg

Dosage

- Adult: 300 to 600 ma/d divided in 3 doses

FIGURE

Duration: as short as possible, depending on clinical progress

Contra-indications, side-efects, precautions

- Do not administer in case of:

· peptic ulcer,
· liver failure,
· known allergy to phenylbutazone.

- Risk of severe sometimes fatal agranulocytosis.
- Should only be used as an analgesic if all other analgesics are ineffective.
- Do not combine with anticoagulants, digitalis, phenytoin or other anti-inflammatory drugs (including aspirin).
- Pregnancy: avoid
- Lactation: avoid

Remarks

- Take with meals.
- Storage: keep below 30°C

PHENYTOIN (Di-hydan(R), Dilantin(R), Epanutin(R).)

District hospital

Therapeutic action

- Anticonvulsive

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Epilepsy, except absence seizure (petit mal)

Preparation

- Tablet of 100 mg

There are also tablets of 25 mg and 50 mg. Adapt the dosage accordingly.

Dosage

- Child : 3 to 8 mg/kg/d divided in 2 or 3 doses
- Adult: 2 to 6 mg/kg/d divided in 2 or 3 doses

FIGURE

Duration: depending on clinical progress

Contra-indications, side-effects, precautions

- Do not administer in case of known allergy.
- Risk of digestive problems: gingival hypertrophy, nausea, vomiting.
- If prolonged usage, risk of haematologic problems. Monitor peripheric blood count if possible and administer folic acid.
- Risk of neurological problems: dizziness, visual problems, mental confusion.
- Allergic reactions: cutaneous eruptions, fever, adenopathy.
- Pregnancy: avoid
- Lactation: avoid

Remarks

- It is not advised to associate phenytoin with oral contraceptives, sulfamides, or chloramphenicol. Combination with other drugs must be closely monitored (diazepam, phenobarbital, barbiturates, digoxin, corticosteroids.).
- Storage: keep below 30°C.

Never use expired phenytoin (risk of under dosage).

PIPERAZINE (Antepar(R), Pripsen(R).)

District hospital

Therapeutic action

- Anthelminthic

Indications

- Ascariasis
- Enterobiasis (pinworm)

Preparation

- Tablets of 300 mg and 500 mg
- Syrup of 750 mg/5 ml = 1 teaspoon

Dosage (expressed in piperazine hydrate)

- Ascariasis : Child: 75 mg/kg, in a single dose Adult :3 to 4 g, in a single dose
- Enterobiasis: Child: 50 mg/kg/d for 5 days Adult: 3 to 4 g/d for 5 days
- Do not exceed indicated doses.

FIGURE

Duration

- Ascariasis : single dose
- Enterobiasis: 1 course of 5 days

Contra-indications, side-effects, precautions

- Do not administer in case of epilepsy, renal or liver failure.
- Risk of overdose and neurological toxicity: dizziness, problems of vision and/or consciousness.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- This drug is still frequently used but considering its ineffectiveness on hookworm and its side-effects, it is often replaced by more broad-spectrum anthelmintic drugs (mebendazole), which are more effective for general deworming.
- 100 mg piperazine hydrate = 120 mg adipate = 125 mg citrata = 104 mg phosphate.
- Advice on sanitation should be given with the treatment.
- Storage: no special temperature requirements.

POTASSIUM Chloride

District hospital

Therapeutic action

- Potassium supplement

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Hypokalemia:

· following diuretic treatment with thiazides
· of other origin (dehydration.)

Preparation

- Tablet of 8 mmol (mEq) of K+ = 600 mg
- Tablet of 6.7 mmol (mEq) of K+ = 500 mg

WARNING, DOSES VARY DEPENDING ON SUPPLIER. Adapt dosage accordingly.

Dosage

- Adult: 7 to 15 mmol/d or 0.5 to 1 g/d
- Do not exceed indicated doses.
- Use slow release tablets.

FIGURE

Duration: depending on clinical progress and duration of diuretic treatment

Contra-indications, side-effects, precautions

- May cause: nausea, vomiting.
- Risk of intestinal ulcers and heartburn, in particular when using quick dissolving tablets.
- Do not combine with spironolactone and other similar diuretics.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- If tablets are not available, a lack of potassium can be corrected by a diet rich in dates, bananas, mangos, oranges, tomatoes.
- One ORS sachet contains 1,5 g of potassium chloride.
- Storage:

PRAZIQUANTEL (Biltricide(R).)

Special department

Therapeutic action

- Schistosomicide, also active on distomiasis

Indications

- Bilharziasis:

· S. haematobium (urinary bilharzia)
· S. mansoni and S. intercalatum (intestinal bilharzia)
· S. japonicum and S. mekongi (hepato-splenic bilharzia)

- Distomiasis: Opisturchis felinus, Clonorchis sinensis, Paragonimum westermani, Fasciola hepatica

Preparation

- Tablet of 600 mg

Dosage

- Bilharziasis S. haematobium, S. mansoni, S. intercalatum
Child and adult :40 mg/kg in a single dose
- Bilharziasis S. japonicum, S. mekongi
Child and adult :60 mg/kg divided in 3 doses in 1 day
- Distomiasis
Child and adult: 75 mg/kg/d divided in 3 doses

FIGURE

Duration

- Bilharziasis S. haematobium, S. mansoni, S. intercalatum: single dose
- Bilharziasis S. japonicum, S. mekongi :3 doses, 1 day
- Distomiasis: Opisturchis felinus, Clonorchis sinensis, Paragonimum westermani :2 to 3 days

Fasciola hepatica :5 to 7 days

Contra-indications, side-effects, precautions

- Risk of allergy.
- May cause: nausea, vomiting, headache.
- Pregnancy: avoid (in most cases, treatment can wait until the end of the pregnancy)
- Lactation :avoid

Remarks

- In an endemic area, antibilharzia treatment will only be effective if preventive measures exist to avoid continuous reinfection.
- Advice on sanitation should be given with the treatment.
- Storage:

PREDNISOLONE (Codelsol(R), Deltastab(R), Prednesol(R).) and PREDNISONE (Decortisyl(R), Econosone(R).)

District hospital

Therapeutic action

- Corticosteroid

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Symptomatic treatment:

· allergic diseases
· inflammatory diseases
· severe asthma

Preparation

- Tablet of 5 mg

Dosage

- Child: initial dose :1 to 2 mg/kg/d maintenance dose: 0.1 to 0.5 mg/kg/d
- Adult: initial dose :20 to 80 mg/d maintenance dose: 5 to 20 mg/d

FIGURE

- In case of prolonged treatment, do not stop the treatment suddenly. Decrease the dose by 5 mg each day.

Duration: depending on clinical progress

Contra-indications, side-effects, precautions

- Do not administer in cases of:

· peptic ulcer,
· fungal and/or viral infections (herpes), or bacterial infections not controlled by antibiotics.

- May cause: hypokalemia, osteoporosis if prolonged treatment.
- Risk of oedema and arterial hypertension as a result of sodium and water retention.
- Risk of adrenal suppression in case of prolonged treatment with daily doses of 15 to 20 mg.
- If daily administration of more than 20 mg, a salt-free diet and potassium supplement are recommended.
- If acute adrenal failure, prescribe hydrocortisone: 100 to 300 mg IV.
- Pregnancy: avoid in the first trimester
- Lactation :avoid

Remarks

- 5 mg prednisolone has the same anti-inflammatory activity as:

· 5 mg prednisone · 4 mg methyl prednisolone
· 0.75 mg dexamethasone · 20 mg hydrocortisone

- Storage: keep below 30°C.

PROBENECID (Benemid(R).)

Health clinic

Therapeutic action

- Prolongs the action of penicillin and ampicillin
- (Anti-gout)

Indications

- In combination with procaine penicillin (or possibly with ampicillin or amoxycillin) in the treatment of gonorrhoea. Can be combined with other penicillin preparations. BENZATHINE PENICILLIN CAN NOT BE USED WITH PROBENEClD.

Preparation

- Tablet of 500 mg

Dosage

In conjunction with penicillin treatment:

- Child (above 2 years): 20 to 25 mg/kg/d
- Adult :1 g/d

FIGURE

Duration: depending on the penicillin treatment

Contra-indications, side-effects, precautions

- Do not administer in children under 2 years.
- Do not combine with acetyl salicylic acid (aspirin).
- Pregnancy :avoid
- Lactation :avoid

Remarks

- The combination of probenecid and procaine penicillin is always indicated for the treatment of gonorrhoea, except in pregnant women.
- Tablets can be taken at the same time as the injection, or preferably, 1/2 hour before.
- Storage: keep below 30°C.

PROGUANIL (Paludrine(R).)

District hospital

Therapeutic action

- Antimalarial

Indications

- Prevention of malaria in association with chloroquine in countries with rare or moderate resistance to chloroquine.

Preparation

- Tablet of 100 mg

Dosage

Conform to national protocol.

For information:

FIGURE

Duration

- Travellers must start to take proguanil associated with chloroquine 24 hours before departure, continue throughout their journey and for 4 to 6 weeks after return.

Contra-indications, side-effects, precautions

- Transitory digestive problems.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Take tablets with some water, every day, at the same time, after the meal.
- Storage: no special precaution.

PROMETHAZINE (Phenergan(R).)

District hospital

Therapeutic action

- Anti-emetic
- Antihistaminic
- Sedative

Indications

- Vomiting
- Allergic reactions due to:

· contact, seasons.
· drugs, insect bites, food.

- Dry cough of allergic origin

Preparation

- Tablets of 25 mg

Dosage

- Child: 1 mg/kg/d divided in 2 or 3 doses
- Adult: 25 to 50 mg/d divided in 2 or 3 doses

FIGURE

Duration: single dose or 1 to 3 days depending on clinical progress

Contra-indications, side-effects, precautions

- Do not drink alcohol during treatment.
- In case of drowsiness, administer in the evening.
- Risk of sedation when combined with alcohol and other drugs that act on the central nervous system: diazepam (Valium(R), phenobarbitone (Gardenal(R)), chlorpromazine (Largactil(R) and chlorpheniramine (Teldvin(R).
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Chlorpheniramine is cheaper, but has no anti-emetic action.
- Storage: keep below 30°C.

PROPRANONOL (Angilol(R), Inderal(R).)

District hospital

Therapeutic action

Beta-blocker, used against hypertension, angina and arrhythmias

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Arterial hypertension
- Angina pectoris
- Arrhythmia diagnosed by a doctor (with ECG)

Preparation

- Tablets of 10 mg and 40 mg

Dosage

-Arterial hypertension
80 mg/d divided in 2 doses, to be increased progressively depending on clinical progress, maximum 320 mg/d
-Prophylaxis for angina pectoris
Initial dose: 30 to 60 mg/d divided in 3 doses, to be increased every 4 days up to a dose of 160 to 320 mg/d
-Prevention of arrhythmia after myocardial infarction
180 to 240 mg/d divided in 2 or 3 doses; start as of the 6th or 9th day after the infarction and continue for 18 months at a dose of 160 mg/d

Duration

- Depending on indication and clinical progress
- Do not stop abruptly.

Contra-indications, side-effects, precautions

-The drug should only be prescribed for patients who are following a prolonged treatment. The treatment should never be stopped suddenly.
- Do not administer in cases of:

· asthma,
· bradycardia below SO/min, bundle-branch block,
· heart failure (or a history of),
· arteritis of the lower limbs, Raynaud syndrome.

- Administer with care in cases of diabetes, digitalis treatment or emphysema, and in cases of renal or liver failure.
- Do not combine with aminophylline (reciprocal inhibition), digitalis (bradycardia), adrenaline (hypertension), curare, M.A.O. inhibitors.
- Pregnancy: no contra-indication
- Lactation :avoid

Remarks

- For the treatment of hypertension, may be combined with a diuretic.
- Storage: no special temperature requirements.

PYRANTEL (Combantrin(R).)

District hospital

Therapeutic action

- Anthelminthic

Indications

- Ascariasis
- Enterobiasis (pinworm)
- Hookworm (ankylostomiasis)

Preparation

- Tablet of 125 mg

There are also tablets of 250 mg. Adapt dosage accordingly.

Dosage

- Ascariasis, enterobiasis, hookworm caused by Ancylostoma duodenalis

Child and adult :10 mg/kg in a single dose

- Hookworm caused by Necator americanus

Child and adult :20 mg/kg/d once daily

FIGURE

Duration

- Ascariasis, enterobiasis, hookworm caused by Ancylostoma duodenalis: single dose
- Hookworm caused by Necator americanus: 3 days

Contra-indications, side-effects, precautions

- Administer with care in case of liver failure.
- May cause: digestive problems, headache, dizziness.
- Pregnancy: avoid (in most cases, the treatment can wait until the end of the pregnancy)
- Lactation: no contra-indication

Remarks

- Generally more expensive than mebendazole and levamisole.
- Sanitation advice should be given with the treatment.
- Storage: no special temperature requirements.

PYRAZINAMIDE (Zinamide(R).)

Special department

Therapeutic action

- "Antituberculous" antibacterial

Indications

- Only for tuberculosis, bacteriologically proven if possible

Preparation

- Tablet of 500 mg

Dosage

According to national protocol.

For information

- Child and adult :25 mg/kg/d maximum
- Can also be given in a dose of 40 mg/kg 2 times a week or 70 mg/kg once a week

Duration: according to national protocol

Contra-indications, side-effects, precautions

- Do not administer in cases of:

· Iiver failure,
· history of allergy to ethionamide, isoniazid and nicotinamide.

- May cause: anorexia, nausea, vomiting, skin allergies, joint pains, gout.
- Pregnancy :avoid
- Lactation: avoid

Remarks

- Warning: antituberculous treatment should only be prescribed in the context of an organised program (well established protocol, regular patient checks and the possibility of laboratory examination).
- Pyrazinamide should not be used alone, but in combination with other "antituberculous" drugs to avoid resistance.
- Storage: keep below 30°C.

PYRIDOXINE = Vitamin B6

District hospital

Therapeutic action

- Vitamin

Indications

- Prevention and treatment of peripheral neuropathies, particularly if isoniazid (INH) has been prescribed

Preparation

- Tablets of 25 mg and 50 mg

Dosage

- Child: 25 to 50 mg/d once daily
- Adult: 50 to 150 mg/d once daily

FIGURE

Duration: depending on clinical progress or as long as the treatement with isoniazid (INH) continues

Contra-indications, side-effects, precautions

- No contra-indication.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Storage: no special temperature requirements

QUININE Salts

District hospital

Therapeutic action

- Antimalarial

Indications

- Treatment of Plasmodium falciparum malaria resistant to chloroquine
- Follow up of injectable quinine given for cerebral malaria or chloroquine resistance

Preparation

- Tablets of 200 mg and 300 mg of quinine salts (generally sulphates or chlorhydrates)

There are also tablets of 100 mg, 250 mg and 500 mg. Adapt dosage accordingly.

Dosage

- Child : 25 to 40 mg/kg/d divided in 3 doses
- Adult: 1.5 to 2 g/d divided in 3 doses

Dosages and doses of the tablets are generally expressed in salts. They are all equal (formiate, sulphate, chlorhydrate, bi-chlorhydrate), except for bi-sulphate which is weaker and thus needs its own special dose.

FIGURE

Duration: 7 days

Contra-indications, side-effects, precautions

- Risk of toxicity in case of doses over 4 g: headache, disturbance of vision, abdominal pain, nausea, buzzing (tinitus) of ears.
- Possible allergic reactions.
- Pregnancy: no contra-indication (do not exceed the therapeutic doses)
- Lactation: no contra-indication

Remarks

- In some regions of South-East Asia, the combination of quinine and tetracycline (25 mg/kg/d) or doxycycline (200 mg/d) for 10 days is necessary because of resistance.
- Antacids, like aluminium hydroxide, can slow down the absorption of quinine.
- Storage: keep below 30°C.

RESERPINE (Decaserpyl(R), Rauwiloid(R), Serpasil(R).)

District hospital

Therapeutic action

- Antihypertensive

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Moderate arterial hypertension (in combination with a diuretic)

Preparation

- Tablets of 0.10 mg, 0.25 mg and 0.50 mg

Dosage

- Adult: 0.10 to 0.25 mg/d to be combined with a diuretic and to be adapted according to therapeutic progress

FIGURE

Duration: depending on clinical progress

Contra-indications, side-effects, precautions

- Do not administer in cases of:

· depression or history of depression,
· peptic ulcer,
· heart and/or severe renal failure,
· epilepsy.

- May cause: nausea, vomiting, gastritis, depression, anxiety, bronchial spasms.
- It has a slow but long lasting action: risk of accumulation.
- Avoid combination with digitalis, quinidine and other anti-arrhythmic drugs, alcohol and suppressors of the central nervous system: diazepam (Valium(R), phenobarbitone (Gardenal(R)) and chlorpromazine (Largactil(R)).
- Pregnancy : avoid
- Lactation: avoid

Remarks

- Storage: keep below 30°C.

RETINOL = VITAMIN A (Ro-A-Vit(R)..)

Health clinic

Therapeutic action

- Vitamin

Indications

- Prevention of vitamin A deficiency
- Treatment of xerophthalmia: reduced night vision, desiccation (drying) and ulceration of the cornea, Bitot's spots.
- Treatment of children specifically vulnerable for vitamin A deficiency: measles, malnutrition, respiratory infections.

Preparation

- Capsules of 50,000 IU and 200,000 IU

There are also capsules of 25,000 IU. Adapt dosage accordingly.

Dosage

- Prevention: Adult and Child above 1 year: 200,000 IU in a single dose every 6 months.

Child under 1 year: 100,000 IU in a single dose every 6 months

- Treatment: Adult and Child above 1 year: 1st, 2nd and 8th day, 200,000 IU once daily.

Child under 1 year : 1st, 2nd and 8th day, 100,000 IU once daily

- Do not exceed indicated doses.

For children under 1 year: when capsules of 50,000 IU are not available, pierce a capsule of 200,000 IU and give 3 drops.

FIGURE

Duration

- Prevention: single dose every 6 months
- Treatment: 1st, 2nd and 8th day; thereafter as for "prevention" if necessary

Contra-indications, side-effects, precautions

- Pregnancy: prevention: avoid, give a single dose just after delivery
treatment: do not exceed a dose of 10,000 Odd (risk of fetal malformation)
- Lactation: no contra-indication

Remarks

- The injectable form has no advantages.
- Food rich in vitamin A: dark green vegetables, palm oil, orange or red coloured fruits and vegetables, eggs, full-cream milk and meat.
- Storage: keep cool.

RIFAMPICIN (Rifadin(R), Rimactane(R).)

Special department

Therapeutic action

- "Antituberculous" and "antileprotic" antibacterial

Indications

- Tuberculosis, bacteriologically proven if possible
- Leprosy (Hansen's disease)

Preparation

- Tablets or capsules of 150 mg and 300 mg

Dosage

According to national protocol.

For information:

- Tuberculosis: 10 mg/kg/d
- Leprosy : 600 mg once every month

FIGURE

Duration: according to national protocol

Contra-indications, side-effects, precautions

- Do not administer if liver failure, porphyria or allergy for rifampicin.
- Risk of hepatotoxicity.
- May cause allergies.
- Urine, stools and secretions may turn red.
- Pregnancy: avoid
- Lactation: avoid

Remarks

- Warning: antituberculous and antileprotic treatments should only be prescribed in the context of an organised program (well established protocol, regular patient checks and the possibility of laboratory examination).
- Rifampicin should not be used alone, but in combination with other "antituberculous" or "antileprotic" drugs to avoid resistance.
- Rifampicin is an expensive antituberculous drug.
- Storage: no special temperature requirements

SALBUTAMOL = ALBUTEROL (Salbulin(R), Salbutan(R), Ventolin(R).)

District hospital

Therapeutic action

- Bronchodilator
- Uterorelaxant

Indications

- Acute or chronic asthma (with continuous dyspnea).
- Bronchitis and obstructive pneumopathies with bronchospasm.
- Prevention of premature delivery: taking over treatment after emergency injectable treatment.

Preparation

- Tablets of 2 mg and 4 mg of salbutamol (in the form of sulphate)
- Syrup of 2 mg/5 ml

Dosage

- Asthma

· Child: 0.10 mg/kg/d divided in 3 doses
· Adult: 6 to 12 mg/d divided in 3 doses

Prevention of premature delivery: 1 tab of 2 mg 4 times a day

FIGURE

Duration: depending on clinical evolution

Contra-indications, side-effects, precautions

-Do not administer in cases of myocardial infarction or acute coronary insufficiency.
-Administer carefully if cardiac insufficiency, arrhythmia, hypertension, diabetes, hyperthyroidism.
-May cause: tachycardia, trembling, dizziness, headache.
-During the treatment, especially if the doses are taken too often, the bronchodilatory effect can decrease: stop treatment.
-Salbutamol is not very efficient for children less than 2 years.
-Pregnancy: no contra-indication
-Lactation: no contra-indication

Remarks

- Storage: keep below 30°C.

SULFADIMIDINE = SULPHADIMIDINE

District hospital

Therapeutic action

- Antibacterial (sulfonamide)

Indications

- Infections of the lower urinary tract without complications: without fever or lumbar pain.

Do not confuse with gonorrhoea (urethral discharge in the morning).

Preparation

- Tablet of 500 mg

Dosage

- Child (above 2 months): 100 to 250 mg/kg/d divided in 3 doses
- Adult: 2 to 6 g/d divided in 3 doses

FIGURE

Duration: minimum 7 days

Contra-indications, side-effects, precautions

- Do not administer:

· for children under 2 months,
· if known allergy to sulfonamides,
· if hematological disorder.

- Frequently causes digestive problems.
- Allergic reactions possible. Stop the treatment and refer to a doctor.
- DRINK A LOT during treatment to prevent kidney stones.
- Do not combine with other antibacterials.
- Pregnancy: CONTRA-INDICATED (use ampicillin if causative bacteria is sensitive)
- Lactation: CONTRA-INDICATED

Remarks

- For upper urinary tract infections and those with fever, cotrimoxazole is more effective.
- Sulfadimidine is nowadays usually replaced by cotrimoxazole.
- Storage: keep below 30°C.

SULFADOXINE + PYRIMETHAMINE (Fansidar(R).)

Special department

Therapeutic action

- Antimalarial

Indications

- Treatment of Plasmodium falciparum malaria resistant to chloroquine and other amino-4-quinolines (Amodiaquine(R).)

Preparation

- Tablet of 500 mg sulfadoxine + 25 mg pyrimethamine

Dosage

- Child: i/2 tab/10 kg, in a single dose
- Adult: 2 to 3 tab, in a single dose

FIGURE

Duration: single dose

Contra-indications, side-effects, precautions

- Do not administer if:

· allergy to sulfonamides,
· renal or liver failure.

- Do not combine with chloroquine.
- Do not administer at the same time as cotrimoxazole.
- May cause: gastro-intestinal problems, nausea, vomiting, cutaneous allergic reactions.
- If the attack is pernicious, treat with quinine.
- Avoid for children under 5 years.
- Pregnancy: CONTRA-INDICATED
- Lactation :avoid

Remarks

- Sulfadoxine + pyrimethamine as prophylaxis has been abandoned because of frequent serious side-effects.
- Warning: there is an increasing number of resistant strains.
- Storage: no special temperature requirements.

SULFAGUANIDINE (Ganidan(R).)

The use of this drug is not advised:

- it has no proven effectiveness;
- it is not included in the WHO essential drug list;
- its purchase is an useless expense.

Therapeutic action

- Antibacterial (sulfonamide)

Indications

- None. It has no effect on the treatment of bacterial diarrhoea : the pathogens have become resistant

Preparation

- Tablet of 500 mg

Dosage

It used to be given as follows:

- Child (above 2 months): 100 mg/kg/d, divided in 4 doses
- Adult: 12 g/d divided in 4 doses

Contra-indications, side-effects, precautions

- Do not administer:

· to children under 2 months,
· if known allergy to sulfonamides.

- Allergic reactions possible. Stop treatment and refer to a doctor.
- Pregnancy: CONTRA-INDICATED
- Lactation: CONTRA-INDICATED

Remarks

- Storage: no special precautions.

TETRACYCLINE (Abfosan(R), Hexacycline(R), Tetramig(R).)

OXYTETRACYCLINE (Terramycine(R).)

DOXYCYCLINE (Doxy 100(R), Granudoxy(R), Spanor(R), Vibramycin(R).)

District hospital

Therapeutic action

- Antibacterials (of the cycline group)

Indications

- Cholera, brucellosis, borreliosis, rickettsiosis
- Gonorrhoea (if allergy or resistance to penicillin)
- Syphilis (if allergy or resistance to penicillin)
- Genital infections with Chlamydia
- Infections with Balantidium coli
- Atypical pneumopathy
- Chloroquine-resistant malaria, in association with quinine

Preparation

- Tetracycline: capsule or tablet of 25 mg
- Doxycycline: capsule or tablet of 100 mg

Dosage

- Tetracycline:

child above 8 years: 25 to 50 mg/kg/d divided in 3 doses
adult: 1 to 3 g/d divided in 3 doses

- Doxycycline:

child above 8 years :4 mg/kg/d once daily
adult: 200 mg/d once daily

- Cholera:

· tetracycline treatment 2 g/d divided in 4 doses for 3 days prophylaxis 1 to 1.5 g/d divided in 2 or 3 doses for 2 days to be repeated every 10 to 15 days
· doxycycline treatment and prophylaxis

child: 4 mg/kg in a single dose
adult: 300 mg in a single dose

Vibrio is increasingly resistant to cyclines.

FIGURE

Duration: 57days (tetracycline or doxycycline); Syphilis :14 days; Chlamydia: 21 days

Contra-indications, side-effects, precautions

- Do not administer:

· to children less than 8 years (colors teeth yellow)
· if renal diseases

- Do not give together with milk, iron or aluminium hydroxide.
- May cause: frequent digestive problems (diarrhoea.).
- Do not combine with other antibiotics.
- Pregnancy: CONTRA-INDICATED
- Lactation: CONTRA-INDlCATED

Remarks

- Take in-between meals.
- Treatments with doxycycline are cheaper and more efficient than those with tetracycline.
- Oxytetracycline has the same indications and doses as tetracycline.
- Storage: keep below 30°C.
Never administer expired tetracyclines or doxycycline

THIABENDAZOLE (Mintezol(R).)

District hospital

Therapeutic action

- Anthelminthic

Indications

- Strongyloidiasis
- Trichinosis
- Cutaneous larva migrans
- Hookworm (ankylostomiasis) and trichocephalosis: mebendazole preferred

Preparation

- Tablet of 500 mg

Dosage

- Strongyloidiasis Child and adult: 50 mg/kg in a single dose
- Trichinosis Child and adult: 50 mg/kg/d divided in 3 doses
- Cutaneous larva migrans Child and adult: 3 g in 30 g vaseline or antipruritic ointment, 3 applications per day during one week
- Chew tablets during the meal.

FIGURE

Duration

- Strongyloidiasis : single dose
- Trichinosis : 5 days
- Cutaneous larva migrans: 7 days

Contra-indications, side-effects, precautions

- Do not administer if allergy to thiabendazole, renal or liver failure.
- May cause: drowsiness, frequent dizziness, nausea, vomiting, diarrhoea.
- Allergic reaction can sometimes be very strong: Quincke oedema, Stevens Johnson syndrome.
- Pregnancy: avoid
- Lactation: avoid

Remarks

- Because of its limited indications, its price and side-effects, do not use for systematic elimination of parasites, but administer cheaper, broad-spectrum anthelminthic drugs.
- Storage: keep below 30°C.

THIAMINE = ANEURIN = VITAMIN B1 (Benerva(R), Bevitine(R).)

District hospital

Therapeutic action

- Vitamin

Indications

- Beri-beri: neurological or cardiac form
- Polyneuritis in alcoholics or due to nutritional deficiency

Preparation

- Tablet of 50 mg

There are also tablets of 10 mg, 25 mg, 100 mg and 250 mg. Adapt dosage accordingly.

Dosage

- Curative treatment

· Child: 10 to 30 mg/d
· Adult: 50 to 100 mg/d - up to 300 mg in case of severe deficiency to be taken once daily or divided in several doses

- Preventive treatment

· Child and adult :5 mg/d

Daily needs

child : 0.3 to 1 mg/d
adult and adolescent : 1.3 to 1.5 mg/d
pregnancy and lactation: 1.5 to 1.8 mg/d

FIGURE

Duration: at least one month for curative treatment

Contra-indications, side-effects, precautions

- No contra-indications, or side-effects with oral administration of vitamin B1.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- The use of injectable vitamin B1 is only justified in exceptional cases (for example in cases of cardiac insufficiency or acute pulmonary oedema caused by an unbalanced diet).
- Storage: closed, non-metallic container.

TOLBUTAMIDE (Artosin(R), Dolipol(R), Rastinon(R).)

District hospital

Therapeutic action

- Sulfamide hypoglycemic agent wich stimulates the secretion of pancreatic insulin

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Diabetes of the adult, non acidocetosic, of insulin independent type and not balanced by a well followed diet

Preparation

- Tablet of 500 mg

Dosage

- Adult: 0.25 to 1.5 g/d at once during breakfast or divided in 3 doses before meals
- Adapt dosage progressively and with great care to elderly people.

FIGURE

Duration: depending on clinical progress and results of laboratory

Contra-indications, side-effects, precautions

- Do not administer to diabetic children under 16 years.
- Do not administer to an insulin-dependant diabetic, or to a patient with renal or hepatic failure.
- Do not administer to an alcoholic: antabuse reaction.
- Hypoglycemic problems to be treated with intake of oral sugar or IV injection if severe.
- Use with many associations to other drugs not advisable: sulfadimidine, prednisone, aspirin.
- Pregnancy :avoid
- Lactation :avoid

Remarks

- Chlorpropamide (Diabinese(R)) is an oral long acting antidiabetic of the same group, used at doses of i/2 to 2 tab/d once daily. Risk of hypoglycemia is higher.
- Another hypoglycemic sulfamide is glibenclamide (Daonil(R)), tablet of 5 mg: 1/2 to 3 tab/d.
- Use if failure of proper diet, and control glycemia regularly.
- Usage of oral antidiabetics does not mean dietetic measures should be cancelled.
- Storage: keep below 30°C.

Injectable drugs

Acetyl salicylate lysine
Adrenaline
Albuterol
Aminophylline
Amoxicillin
Ampicillin
Aspirin
Atropine sulphate
Benzathine penicillin G
= Benzathine benzyl penicillin
Benzyl penicillin = Penicillin G
Butylscopolamine = Butylhyoscine
Chloramphenicol
Chloramphenicol in oil
Chloroquine
Chlorphenamine = Chlorpheniramine
Chlorpromazine
Cloxacillin
Dexamethasone
Dexchlorpheniramine
Diazepam
Digoxin
Dihydralazine
Dipyrone*
Epinephrine
Ergometrine
Furosemide = Frusemide
Gentamicin
Glucose or dextrose (hypertonic)
Hydralazine
Hydrocortisone
Hydroxocobalamin
Hyoscine butylbromide
Ketamine
Levorenine
Lignocaine = Lidocaine
Lignocaine hyperbaric
= Lidocaine hyperbaric
Metamizol*
Methylergometrine
Metoclopramide
Noramidopyrine*
Oxytocin
Pentazocine
Pentobarbital
Phenobarbitone = Phenobarbital
Phytomenadione
Procaine penicillin = Procaine benzyl penicillin
Procaine benzyl penicillin + Benzyl penicillin = PPF
Potassium chloride
Promethazine
Quinine (salts)
Theophylline
Salbutamol
Sodium bicarbonate
Sodium chloride (hypertonic)
Streptomycin
Sulfadoxine + pyrimethamine*
Thiopentone = Thiopental
Vitamin B12
Vitamin K1

* The use of this drug is not advised.

ACETYL SALICYLATE LYSINE - "ASPIRIN" (Aspegic(R).)

District hospital

Therapeutic action

Same as acetyl salicylic acid (aspirin):

- analgesic
- antipyretic
- anti-inflammatory

The action is fast, intense and prolonged (6 hours).

Indications

- Intense pain
- High fever

Preparation and route of drug administration

- Vial of 0.5 g of aspirin (0.1 g/ml, 5 ml) acetyl salicylate Iysine for deep IM injection, slow IV or infusion
- Vial of 1 g of aspirin (0.2 g/ml, 5 ml) acetyl salicylate Iysine for deep IM injection, slow IV or infusion

Dosage

- Children above 6 years: 10 to 25 mg/kg/d

· from 6 to 10 years

Vial of 0.5 g: 0.5 to 1 ml per injection, or 1/2 to 1 vial/d divided in 5 injections
· above 11 years
Vial of 0.5 g :1 to 2 ml per injection, or 1 to 2 vials/d divided in 5 injections

- Adult
0.5 to 1 g per injection, without giving more than 4 g/d divided in 4 injections (8 vials of 0.5 g or 4 vials of 1 g)

Duration: depending on clinical progress

Contra-indications, side-effects, precautions

- Do not administer to children under 6 years.
- Do not administer if gastro-duodenal ulcer, haemorrhage or risk of haemorrhaging.
- Do not administer for the treatment of gout.
- Use with care for asthmatic patients.
- Can cause allergic reactions, haemorrhage.
- Pregnancy: avoid, especially at the end of pregnancy
- Lactation: avoid

Remarks

- Do not use 1 g vials for children.
- Do not mix other drugs in the same syringe.
- Do not use solutions that are not clear or which contain crystals.
- Storage: keep below 30°C.

ADRENALINE = EPINEPHRINE = LEVORENINE

District hospital

Therapeutic action

- Sympathomimetic

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Anaphylactic shock
- Asthma
- Cardio-respiratory arrest
- Hypotension caused by local or regional anaesthesia (spinal anaesthesia)

Preparation and route of drug administration

- Ampoule of 0.25 mg (0.25 mg/ml, 1 ml) for SC or slow diluted IV injection
- Ampoule of 1 mg (1 mg/ml, 1 ml) for SC or given in slowly diluted IV injection

Dosage

- Child 0 to 1 year : SC: 0.10 mg/injection (IV diluted: same dose diluted in 20 ml)
- Child 1 to 5 years : SC: 0.25 mg/injection (IV diluted: same dose diluted in 20 ml)
- Child 5 to 15 years: SC: 0.50 mg/injection (IV diluted: same dose diluted in 20 ml)
- Adult : SC: 1 mg/injection (IV diluted: same dose diluted in 20 ml)
- Do not exceed indicated doses: risk of arrhythmia.
- Be careful when treating elderly patients: risk of heart failure.
- For IV injection, dilute with isotonic solution of sodium chloride or glucose.

FIGURE

Duration: depending on clinical progress

Contra-indications, side-effects, precautions

- Do not administer in cases of:

· arterial hypertension,
· angina.

- If used intravenously (reanimation), preferably use diluted.
- Pregnancy: CONTRA-INDICATED except in emergencies
- Lactation: no contra-indication

Remarks

- The adrenaline solution is colourless; discard any ampoules showing a pink or brown coloration.
- Storage: keep cool

AMINOPHYLLINE (Euphyllin(R).) and THEOPHYLLINE

District hospital

Therapeutic action

- Bronchodilator

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Asthma attacks
- Severe respiratory problems due to bronchopneumonia
- Apnoea in a premature infant

Preparation and route of drug administration

- Ampoule of 250 mg (25 mg/ml, 10 ml) for very slow IV injection (10 to 15 minutes) or infusion. NEVER GIVE IV QUICKLY. Better to use 10% dilutions (especially if rectal use).
- Administration by IM is possible but painful.
- Children can be treated rectally (dilution 1/10), but the absorption is irregular.
- Apnoea in a premature infant: can be used orally (dilution 1/10) as adjuvant in the treatment of apnoea. Dosage: 2.5 to 5 mg/kg initial dose, following doses 2 mg/kg/24 hours.

Dosage

- Child and adult :5 mg/kg/injection
- Reduce the dose in cases of heart failure and for elderly patients.
- Make sure the patient has not taken oral theophylline before-hand.

FIGURE

Duration: depending on clinical progress, change to oral treatment as soon as possible

Contra-indications, side-effects, precautions

- Paediatrics:

· never combine with erythromycin,
· the therapeutic dose is near the toxic dose.

- Toxic in case of overdose:

· early signs: vomiting, hyperthermia,
· sign of intoxication: convulsions.

- Administer with care to children under one year.
- Avoid combination with erythromycin or phenobarbitone.
- Pregnancy: avoid, particularly at the end of the pregnancy
- Lactation: avoid

Remarks

- Administration of theophylline for the same indications and at the same dosage (5 mg/kg) in very slow IV injection. Attention, preparation in ampoule of 240 mg/4 ml: calculate exactly the volume to inject.
- Storage: keep cool.

AMOXICILLIN (Amoxil(R), Clamoxyl(R).) AMPICILLIN (Amfipen(R), Penbritin(R).)

District hospital

Therapeutic action

- Antibacterial (antibiotic) of the penicillin group

Indications

- Severe infections: septicemia, endocarditis, meningitis, pulmonary infections, burns
- First choice in the treatment of uro-genital infections in pregnant women

Preparation and route of drug administration

- Vials of powder of 500 mg or 1 g for IM, IV injection or infusion

Dosage

Amoxicillin and ampicillin have the same indications and doses when injected:

- Child: 50 to 100 mg/kg/d divided in 3 injections
- Adult: 3 to 4 g/d divided in 3 injections
- The 3 injections/day are necessary.
- In case of severe infections, the dose can be raised to:

Child: 200 mg/kg/d; Adult :12 g/d

FIGURE

Duration: 7 days of antibiotic therapy; change to oral treatment as soon as possible

Contra-indications, side-effects, precautions

- Do not administer if known allergy to penicillin.
- If allergic reaction, stop treatment and refer to a doctor.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Combination with aminoglycoside (e.g. gentamicin) is sometimes necessary (need medical advice).
- THE POWDER IN THE VIALS IS THE SAME FOR ALL METHODS OF ADMINISTRATION ALTHOUGH THEY MAY BE LABELEED DIFFERENTLY. Some solvents that come with the vials contain lidocaine for IM injections. Once mixed with its solvent, the solution can no longer be used for IV injection. If you use sterile water as solvent, both IM and IV injections are possible.
- Storage: keep cool

· Once dissolved, the liquid must be clear and should be used the same day.
· Diluted in a glucose infusion, ampicillin stays stable for 6 hours; in sodium chloride it stays stable for 12 hours. It is recommended that it be injected directly into the infusion tube.
· Amoxicillin is not as stable as ampicillin (can not be kept more than one hour in glucose solution) and is more expensive (for the same dosage).

ATROPINE Sulphate

District hospital

Therapeutic action

- Antispasmodic and parasympatholytic

Indications

- Spasms of the digestive and uro-genital tract (colics, ulcers and severe gastritis)
- Premedication in case of anaesthesia
- Intoxication with organophosphate insecticide

Preparation and route of drug administration

- Ampoule of 1 mg (1 mg/ml, 1 ml) for SC, IV, IM injection or eventually for oral use

Dosage

- Child: 0.01 to 0.02 mg/injection or per os diluted
- Adult: 0.5 to 1 mg/injection or per os diluted
It is possible to repeat the injection if necessary.
- Intoxication with organophosphates: 2 to 4 mg/IV injection every 5 to 10 minutes until signs of effect of the atropine appear (dilation of pupils).

FIGURE

Duration: depending on clinical progress: single dose or 1 to 3 days

Contra-indications, side-effects, precautions

- Do not administer in cases of:

· urinary retention, cardiac problems, glaucoma,
· high fever in children: decreased transpiration, risk of hyperpyrexia, anoxia, convulsions, cardio-respiratory arrest.

- May cause: dry mouth, constipation, dizziness, headache.
- Do not combine with chlorpromazine or promethazine.
- Do not use for minor symptoms.
- Pregnancy: avoid, particularly at the end of the pregnancy; NO PROLONGED TREATMENTS
- Lactation: avoid; NO PROLONGED TREATMENTS

Remarks

- Do not use for convenience.
- Storage: no special temperature requirements.

BENZATHINE PENICILLIN G = BENZATHINE BENZYL PENICILLIN (Penidural(R).)

District hospital

Therapeutic action

- Antibacterial (antibiotic) with prolonged action: 15 to 20 days

Indications

- Syphilis
- Bejel, Yaws
- Prevention of rheumatoid arthritis (RA)

Preparation and route of drug administration

- Vial of powder of 2.4 M IU = 1.44 g only for IM injection (NEVER IV or infusion)

There are also vials of 1.2 M IU = 0.72 g and 0.6 M IU = 0.36 g. Adapt dosage accordingly.

Dosage

- Child: 50,000 to 100,000 IU/kg/injection
- Adult: 1 to 3 M IU/injection

FIGURE

Duration: depending on indications:

- Bejel, Yaws: single dose
- Prevention of rheumatoid arthritis: every 4 weeks
- Syphilis (primary and secondary): repeat after 15 days

Contra-indications, side-effects, precautions

- Do not administer if known allergy to penicillin.
- If allergic reaction, stop treatment and refer to a doctor.
- Do not combine with other antibiotics.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- After injection, benzathine penicillin releases the penicillin G very slowly from its complex which provides the long action of 15 to 20 days. This form of penicillin is not suitable for urgent cases (blood level too low), nor for gonorrhoea.
- Benzathine penicillin should not be used as prevention, except in case of RA.
- Storage: keep below 30°C.

Afler preparation, the suspension must be used within 24 hours.

BENZYL PENICILLIN = PENICILLIN G = CRYSTALLINE PENICILLIN (Crystapen(R)...)

District hospital

Therapeutic action

- Antibacterial (antibiotic) with rapid action and elimination (6 hours)

Indications

- Infections sensitive to penicillin: pneumonia, tonsillitis, anthrax, septicemia, meningitis.

Preparation and route of drug administration

- Vials of powder of 1 M IU and 5 M IU for IM, infusion, IV injection (preferably in the infusion tube)

This presentation is rarely used because it requires intensive monitoring in a hospital environment: INJECTION EVERY 6 HOURS THROUGH AN INFUSION TUBE.

Dosage

- Child: 80,000 IU/kg/d divided in 4 injections or infusions (maximum 400,000 IU/kg/d)
- Adult: 1 to 3 M IU/d divided in 4 injections or infusions (maximum 10 to 20 M IU/d)

Duration: depending on indications and clinical progress

Contra-indications, side-effects, precautions

- Do not administer in case of known allergy to penicillin.
- If allergic reaction, stop treatment and refer to a doctor.
- Do not mix in the same infusion with other antibacterials (gentamicin.).
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- 600 mg benzylpenicillin = 1 million international units (M IU) = 1 mega unit.
- Warning: the labels are not always very clear. Do not confuse penicillin G with LONG ACTING PENICILLIN CONTAINING PENICILLIN G: procaine penicillin G or benzathine penicillin G. Long acting penicillin CANNOT BE USED FOR IV INJECTION OR INFUSION.
- Storage: keep below 30°C.

After preparation, the solution must be clear and used within 24 hours.

CHLORAMPHENICOL (Chloromycetin(R), Tifomycine(R).)

District hospital

Therapeutic action

- Antibacterial (antibiotic)

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST ME UNDER MEDICAL SUPERVISION

- Typhoid fever
- Meningitis
- Bronchopneumonia
when oral administration is not possible

Preparation and route of drug administration

- Vial of powder of 1 g of chloramphenicol (as sodium succinate) for IM or IV injection

Dosage

- Child : 50 to 100 mg/kg/d divided in 3 injections
- Adult: 1 to 4 g/d divided in 3 injections
- For any indication except typhoid fever, do not exceed a total dose of 26 g for adult.
- Typhoid fever: conform to national protocol; if not available, start the first day with half the dose and increase gradually.

FIGURE

Duration

- Minimum 5 days, change to oral treatment as soon as possible.
- Typhoid fever: continue antibiotic therapy for 15 days after the fever has gone.

Contra-indications, side-effects, precautions

- If treatment causes anaemia, stop treatment and refer to a doctor.
- Do not combine with other antibiotics without medical advice.
- For newborn babies: CONTRA-INDICATED.
- Pregnancy: CONTRA-INDICATED
- Lactation: CONTRA-INDICATED during the first two months

Remarks

- In spite of its severe but rare haematological toxicity, the use of chloramphenicol is justified because of its effectiveness on the serious infections mentioned above. This drug has also the advantage of being cheap.
- ORAL TREATMENT IS MORE EFFECTIVE THAN IM INJECTION (the blood- and tissue concentrations are better with oral absorption).
- Storage: keep below 30°C.
Once dissolved, the solution must be clear and used within 24 hours.

CHLORAMPHENICOL IN OIL ("long acting") (Tifomycine(R).)

Special department

Therapeutic action

- Antibacterial (antibiotic) with prolonged action (a few weeks)

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Epidemics of purulent mngococcal meningitis

Preparation and route of drug administration

- Ampoule of oily suspension of 500 mg (250 mg/ml, 2 ml) for IM injection only, NEVER IV

Dosage

- Child: 50 to 100 mg/kg/injection
- Adult: 2 to 3 g/injection
- A second injection can be given 3 days later if necessary (same dose).

FIGURE

Duration: single dose

Contra-indications, side-effects, precautions

- Do not combine with other antibiotics.
- Pregnancy: CONTRA-INDICATED
- Lactation: CONTRA-INDICATED

Remarks

- "A single dose injection of chloramphenicol in oil has been proven effective in the treatment of patients of all ages. This antibiotic is therefore the recommended treatment in case of epidemics, however it is not suitable for the treatment of patients with Streptococcus pneumoniae or Haemophilus influenzae" (WHO - epidemiological record, n°16-20, April 1990).
- No chemoprophylaxis is recommended. It is necessary, for suspected cases, to be examined at the first sign of the disease.
- Storage: keep belozv 30°C.

CHLOROQUINE (Nivaquine(R), Resochin(R).)

District hospital

Therapeutic action

- Antimalarial

Indications

- Severe malaria: outside chloroquine resistant areas, if oral treatment is not possible.

Attention: if malaria must be treated by injection, use quinine, if available, in preference.

Preparation and route of drug administration

- Ampoules of 80 mg base, 100 mg base, 200 mg base and 300 mg base (40 mg base/ml and 50 mg base/ml) for IM, SC injection, slow infusion

Dosage

- THE THERAPEUTIC DOSES ARE LOWER IF INJECTED THAN IF TAKEN ORALLY.
- THE MAXIMUM DOSE is 25 mg (base)/kg/d, whatever the way of injection.

· IM or SC
3.5 mg (base)/kg/6 hours up to a total dose of 25 mg (base)/kg
· Infusion
5 mg (base)/kg/8 hours up to a total dose of 25 mg (base)/kg; monitor that the infusion proceeds very slowly
In case of cerebral malarial, the initial dose can be 10 mg (base)/kg, up to a total dose of 25 mg (base)/kg.

Duration

- Maximum 1 to 3 days. Do NOT GIVE THE COMPLETE TREATMENT BY CHLOROQUINE INJECTIONS.

AS SOON AS POSSIBLE, CHANGE TO ORAL TREATMENT 24 HOURS AFTER THE LAST INJECTION, give the oral dose as recommended for the second day of the treatment. If necessary, use a gastric tube.

Contra-indications, side-effects, precautions

- Do not use IM for children under 5 years. IN CASE OF VITAL NEED, USE SC (absorption is slower).
- The therapeutic dose is near the toxic dose: check that the patient has not taken chloroquine tablets in the preceding days. If oral treatment, taken correctly, fails, use quinine.
- Risk of cardiac toxicity and hypotension: sudden death.
- Sign of toxicity: convulsions.
- Do not combine injectable chloroquine and injectable quinine.
- Follow strict aseptic procedures because abscesses frequently develop after injections.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Storage: no special temperature requirements

CHLORPHENAMINE = CHLORPHENIRAMINE (Piriton(R), Teldvin(R).)

District hospital

Therapeutic action

- Antihistaminic

Indications

- Severe allergic reactions due to:

· contact, seasons.
· drugs, insect bites, food.

Preparation and route of drug administration

- Ampoule of 10 mg (10 mg/ml, 1 ml) for IM, slow IV or SC injection

Dosage

- Child (above 2 years): 1 mg/kg/injection
- Adult: 25 to 50 mg/injection

FIGURE

Duration: depending on indications and clinical progress; change to oral treatment as soon as possible

Contra-indications, side-effects, precautions

- Risk of drowsiness.
- Do not administer to children under 2 years.
- Risk of sedation when combined with alcohol and other drugs that act on the central nervous system: diazepam (Valium(R)), phenobarbitone (Gardena(R)) and chlorpromazine (Largactil(R).
- Pregnancy:avoid
- Lactation :avoid

Remarks

- Chlorpheniramine has not anti-emetic properties.
- Promethazine has stronger sedative effects.
- 5 mg dexchlorpheniramine (Polaramine(R)) has the same effect as 10 mg chlorpheniramine.
- Storage: keep below 30°C.

CHLORPROMAZINE (Largactil(R).)

District hospital

Therapeutic action

- Sedative and anti-emetic neuroleptic
- Major tranquillizer

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Severe state of agitation
- Very severe vomiting, intractable hiccup

Preparation and route of drug administration

- Ampoule of 50 mg (25 mg/ml, 2 ml) for deep IM injection or infusion

Dosage

Varies from one patient to another:

- Child: 0.5 mg/kg/injection
- Adult: 25 to 100 mg/injection

In cases of eclampsia, the dose can be doubled if necessary.

- Do not exceed indicated doses.

FIGURE

Duration

- Depending on indications and clinical progress, several days of treatment are sometimes needed for very agitated patients.

Contra-indications, side-effects, precautions

- If temperature rises after the injection, stop treatment. It may be a sign of the neuroleptic malignant syndrome.
- Risk of extrapyramidal disorder in case of prolonged treatment.
- Risk of orthostatic hypotension.
- Risk of sedation when combined with alcohol and other drugs that act on the central nervous system: diazepam (Valium(R), phenobarbitone (Gardenal(R)) and chlorpheniramine (Teldvin(R)).
- Pregnancy: avoid prolonged use
- Lactation :avoid

Remarks

- Can be used in case of an eclamptic attack. However, the use of diazepam (Valium(R)) is preferable.
- For intractable hiccup, use a gastric aspiration tube as well.
- Storage: keep below 30°C.

CLOXACILLIN (Orbenin(R).)

District hospital

Therapeutic action

- Antibacterial (antibiotic) of the penicillin group, acting particularly on penicillinaseproducing staphylococci

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Staphylococcal infections resistant to other antibiotics: chronic osteomyelitis, pulmonary staphylococcal infections of the new-born.

Preparation and route of drug administration

- Vials of powder of 250 mg and 500 mg for IM or IV injection

Dosage

- Child: 100 mg/kg/d divided in 3 or 4 injections
- Adult: 1 to 2 g/d divided in 3 or 4 injections
- If severe infections, the dose can be doubled: maximum 6 g/d.

FIGURE

Duration

- Minimum 7 days of antibiotic therapy.
- Pulmonary staphylococcal infections of the new-born: 10 days.
- Change to oral treatment as soon as possible.

Contra-indications, side-effects, precautions

- Do not administer if known allergy to penicillin.
- If allergic reaction, stop treatment and refer to a doctor.
- Pregnancy: no contra-indication
- Lactation:nocontra-indication

Remarks

- A little enters the cerebro-spinal fluid.
- Storage: keep coal.

After preparation, the solution should be clear and must be used within 24 hours.

DEXAMETHASONE phosphate (Decadron(R), Oradexon(R).)

District hospital

Therapeutic action

- Hormone glucocorticoid

Indications

- Anaphylactic shock
- Status asthmaticus
- Acute laryngitis with signs of respiratory distress
- Severe allergies: Quincke's oedema

Preparation and route of drug administration

- Ampoule of 4 mg dexamethasone phosphate (4 mg/ml, 1 ml) for deep IM, IV injection or infusion

Sometimes, the dose is expressed in dexamethasone sodium phosphate:
4 mg dexamethasone phosphate = 5 mg dexamethasone sodium phosphate.

Dosage

- Child and adult: 0.5 to 10 mg/d depending on indication and severity

FIGURE

Duration: Depending on clinical progress; for the treatment of shock, a single injection can be sufficient

Contra-indications, side-effects, precautions

- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- If prolonged treatment, reduce the doses gradually, otherwise adrenal failure may develop.
- 5 mg prednisolone has the same anti-inflammatory activity as:

· 5 mg prednisone
· 4 mg methyl prednisolone
· 0.75 mg dexamethasone
· 20 mg hydrocortisone

- Dexamethasone acetate (Dectancyl(R) is a suspension only used for local treatments: intra- or peri-articular injection, peridural.
- Storage: keep cool if possible.

DIAZEPAM (Tensium(R), Valium(R)

District hospital

Therapeutic action

- Anxiolytic, sedative
- Anticonvulsive
- Muscle relaxant

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Agitation
- Premedication in anaesthesia
- Convulsions, eclampsia
- Tetanus

Preparation and route of drug administration

- Ampoule of 10 mg (5 mg/ml, 2 ml) for IM, slow IV injection or rectal administration
- The injectable solution can also be used orally.

Dosage

- Agitation - Premedication child :0.3 mg/kg/injection adult :10 to 20 mg/injection
- Convulsions child :0.5 mg/kg/injection adult :25 mg or + /injection
- Tetanus child :0.3 to 1 mg/kg/iniection adult :50 to 100 mg/injection
- For elderly patients, halve the dose.
- Newborn and child, rectal administration: 0.5 mg/kg, repeat if necessary.

FIGURE

Duration

- Depending on clinical progress: 1 to 2 days.
- In case of tetanus or convulsions: repeat every 6 hours.
- If convulsions do not stop after the first injection, the same dose can be repeated 10 minutes later.

Contra-indications, side-effects, precautions

- Do not administer if respiratory depression.
- Risk of respiratory depression if injected IV too quickly.
- IV, IM: painful injection; rectal or oral administration are preferred.
- If administered IV or rectally: dilute 1 to 5 = 10 mg in 10 ml.
- Signs of intoxication (5 times the therapeutic dose): hypothermic coma.
- Risk of sedation when combined with alcohol and other drugs that act on the central nervous system: chlorpromazine (Largactil(R), phenobarbitone
(Gardenal(R)) and chlorpheniramine (Teldvin(R)).
- When used intravenously, make sure that respiratory equipment is available.
- Pregnancy: avoid, except if vital risk
- Lactation: avoid

Remarks

- Treat also hyperthermia which often causes convulsions.
- The diluted solution is normally cloudy.
- Storage: no special temperature requirements

DIGOXIN (Lanoxin(R)..)

District hospital

Therapeutic action

- Cardiotonic (supports the cardiac contraction, slows down and regulates the cardiac rhythm)

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Heart failure, sinus arrhythmia (fibrillation, flutter, paroxysmal tachycardia)
DIAGNOSED BY A DOCTOR

Preparation and route of drug administration

- Ampoule of 0.50 mg (0.25 mg/ml, 2 ml) for IM or slow IV injection

Dosage

- Child

· Initial dose : 0.010 mg/kg (= 10 mcg/kg), repeat 3 to 4 times/24 hours if necessary
· Maintenance dose: 0.010 mg/kg/d once daily

- Adult

· Initial dose : 0.25 to 0.5 mg/d, repeat 3 to 4 times/24 hours if necessary
· Maintenance dose: 0.25 mg/kg/d once daily

Duration: depending on clinical progress; change to oral treatment as soon as possible

Contra-indications, side-effects, precautions

- Do not administer if:

· bradycardia,
· ill defined heart rhythm disorders.

- The pulse must be monitored closely at the beginning of the treatment.
- The therapeutic dose is near the toxic dose.
- Signs of overdose: nausea, vision problems, disorientation or confusion, rhythm problems, problems of atrio-ventricular conduction. If so, decrease dose or stop the treatment. Nausea or vomiting are early signs of overdose.
- Higher risk of toxicity in case of hypokalemia (especially in combination with a diuretic treatment) and in case of calcemia (do not inject calcium at the same time).
- Administer with care in cases of renal failure.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Storage: no special temperature requirements.

ERGOMETRINE and METHYLERGOMETRINE (Methergin(R).)

District hospital

Therapeutic action

- Uterotonic

Indications

- Treatment of post-partum and post-abortion haemorrhage

Preparation and route of drug administration

- Ampoule of 0.2 mg/ml, 1 ml of methylergometrine maleate
- Ampoule of 0.5 mg/ml, 1 ml of ergometrine maleate for IM, slow IV or intramural injection (injection in the uterus)

Dosage

- 0.2 mg/injection, to be repeated if necessary every 2 to 4 hours depending on urgency (0.2 mg = 1 ml of methylergometrine = 0.4 mg of ergometrine)
If bleeding persists after 3 injections, refer to a doctor.
- Do not exceed a total of 5 doses.

Duration: depending on clinical progress

Contra-indications, side-effects, precautions

- Before administration, be sure that the expulsion of the placenta is complete.
- Do not administer during delivery.
- Do not administer in cases of severe hypertension, pre-eclampsia.
- Pregnancy: CONTRA-INDICATED
- Lactation :avoid

Remarks

- Before using this drug, be sure there is no multiple pregnancy. Do not use before the birth of the last child.
- Do not confuse with ergotamine, a related drug, used for totally different indications.
- Storage: refridgerated

· Do not freeze.
· The colour of the solution is normally white to pink; if it becomes yellow/green, the solution has deteriorated.
· Methylergometrine is as sensitive to heat as ergometrine.

FUROSEMIDE = FRUSEMIDE (Lasix(R).)

District hospital

Therapeutic action

- Diuretic

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

Emergency treatment of:

- Oedema caused by renal, heart or liver failure
- Hypertensive crisis

Preparation and route of drug administration

- Ampoule of 20 mg (10 mg/ml, 2 ml) for IM or slow IV injection

Dosage

- Child: 0.5 to 1 mg/kg/injection
- Adult: 20 to 40 mg/injection
- In cases of acute pulmonary oedema, up to 250 mg can be given.

FIGURE

Duration: depending on clinical progress

Contra-indications, side-effects, precautions

- Do not administer in cases of oedema caused by kwashiorkor.
- Risk of hypokalemia (increased toxicity of digoxin if administered simultaneously).
- Pregnancy:avoid
- Lactation: no contra-indication

Remarks

- In case of prolonged treatment, change to oral treatment as soon as possible, after the injectable emergency treatment.
- Storage: keep below 30°C.

GENTAMICIN (Cidomycin(R), Garamycin(R), Gentallin(R).)

District hospital

Therapeutic action

- Antibacterial (antibiotic)

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Severe infections caused by bacteria resistant to other antibacterials (gram negative, pyocyanic): septicemia, osteomyelitis.
- Severe upper urinary tract infections: pyelonephritis.

Preparation and route of drug administration

- Ampoule of 10 mg (10 mg/ml, 1 ml) for IM or slow IV injection or infusion
- Ampoule of 40 mg (20 mg/ml, 2 ml) for IM or slow IV injection or infusion
- Ampoule of 80 mg (40 mg/ml, 2 ml) for IM or slow IV injection or infusion
- Ampoule of 160 mg (80 mg/ml, 2 ml) for IM or slow IV injection or infusion

Dosage

- Child and adult: 3 to 6 mg/kg/d divided in 2 or 3 injections

FIGURE

Duration: depending on indications and clinical progress: 7 days minimum Limit the duration of the treatment because of the risk of toxicitv.

Contra-indications, side-effects, precautions

- Do not administer if:

· renal failure,
· hearing and vestibular problems (dizziness),
· allergy to gentamicin.

- Risk of renal, cochlear and vestibular toxicity.
- Potentiates the action of muscle relaxants and certain general anaesthetics: risk of respiratory paralysis.
- Do not use with potent diuretics (furosemide).
- Gentamicin can be used in combination with a penicillin (benzyl penicillin or ampicillin), but only on medical advice.
- Gentamicin must not be mixed with other products in the same syringe or infusion, specially with penicillin.
- Pregnancy: avoid
- Lactation :avoid

Remarks

- This drug has no effect on gonorrhea and syphilis.
- Does not enter the cerebrospinal fluid (cannot be used in the treatment of meningitis).
- Storage: keep below 30°C.

When using plastic syringes, inject immediately after preparation. The solution must be clear.

HYDRALAZINE (Apresoline(R).) and DIHYDRALAZINE (Nepressol(R).)

District hospital

Therapeutic action

- Antihypertensive with vasodilatory action

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Hypertensive crisis and especially eclampsia and pre-eclampsia

Preparation and route of drug administration

- Ampoule of 20 mg (20 mg/ml, 1 ml and 10 mg/ml, 2 ml) of powder for IM or slow IV injection or infusion

Dosage

- Adult: 5 to 20 mg/injection depending on clinical situation; this dose can be repeated after 20 to 30 minutes.
- Infusion: dilute 4 ampoules in 500 ml sodium chloride 0.9%; increase infusion rate progressively up to 30 drops/minute; do not dilute in glucose solutions which inactivates hydralazine.
- Do not exceed indicated doses.
- In case of overdose (uncontrolled hypotension), use a plasma substitute, preferably a polygeline fluid (Haemacel(R)).
- If the hypertension is under control, reduce the doses progressively. A sudden stop can provoke a hypertensive crisis.

FIGURE

Duration: depending on clinical progress; change to oral treatment as soon as possible

Contra-indications, side-effects, precautions

- Do not administer if:

· coronary insufficiency,
· recent myocardial infarction,
· tachycardia.

- Take care when administering to elderly patients or patients who have had cerebrovascular accidents in the past.
- Do not combine with adrenaline.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Storage: keep below 30°C.

HYDROCORTISONE phosphate, succinate, hemi-succinate (Efcortesol(R), Solu-cortef(R).)

District hospital

Therapeutic action

- Glucocorticoid hormone

Indications

- Anaphylactic shock
- Status asthmaticus
- Acute laryngitis with signs of respiratory distress
- Severe allergies: Quincke's oedema

Preparation and route of drug administration

- Vial of powder of 100 mg for IM or IV injection or infusion

There are also other doses. Adapt dosage accordingly.

Dosage

- Child: 1 to 5 mg/kg/d divided in 2 or 3 injections
- Adult: 100 mg/injection, repeat if necessary

FIGURE

Duration: depending on clinical progress; change to oral treatment as soon as possible

Contra-indications, side-effects, precautions

- Avoid prolonged administration if:

· peptic ulcer,
· diabetes
· cirrhosis.

- Increases the toxicity of digoxin.
- Pregnancy: avoid, particularly during the first 3 months
- Lactation: no contra-indication

Remarks

- 5 mg prednisolone has the same anti-inflammatory activity as:

· 5 mg prednisone
· 4 mg methyl prednisolone
· 0.75 mg dexamethasone
· 20 mg hydrocortisone

- Hydrocortisone acetate suspension is only used as a local treatment: intra- or periarticular injection, epidural.
- Storage: keep below 30°C.

HYDROXOCOBALAMIN = VITAMIN B12 (Cobalin(R), Docemine(R), Novobedouze(R), Redisol(R).)

District hospital

Therapeutic action

- Vitamin

Indications

- Biermer anaemia (due to decreased absorption of vitamin B12).
- Intoxication with cyanide ions, caused by a diet based on insufficiently prepared cassava.

Preparation and route of drug administration

- Ampoule of 1 mg/ml, 1 ml (1 mg = 1,000 microgrammes) for IM injection

Dosage

- Child and adult

· Initial treatment: 1 mg/d or 3 times/week up to a total dose of 10 mg
· Followed by :1 mg/month

Duration

- Biermer anaemia: continue for life.

Contra-indications, side-effects, precautions

- Do not administer in cases of malignant tumor.
- May cause allergic reactions (urticaria, erythema.), pain at injection site, acne.
- Colors urine red.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Cyanocobalamin has the same indications, the same preparation and the same dosage.
- Except for Biermer anaemia, lack of vitamin B12 (stored in the liver) is rare. Daily needs: 0,002 to 0,004 mg.
- Vitamin B12 at high doses is recommended as an antalgic by certain manufacturers (2 mg, 10 mg, 20 mg/ampoule): this antalgic activity has not been proven.
- Storage: keep below 15°C.

HYOSCINE BUTYLBROMIDE = BUTYLSCOPOLAMINE = BUTYLHYOSCINE (Buscopan(R).)

District hospital

Therapeutic action

- Antispasmodic, parasympatholytic

Indications

- Spasms of the digestive and uro-genital tract (colics, ulcers and severe gastritis)

Preparation and route of drug administration

- Ampoule of 20 mg (20 mg/ml, 1 ml) for IM or IV injection

Dosage

- Child: 0.3 to 1 mg/kg/injection
- Adult: 10 mg/injection

It is possible to repeat the injection if necessary.

FIGURE

Duration: depending on clinical progress: single dose or 1 to 3 days

Contra-indications, side-effects, precautions

- Do not administer if:

· urinary retention, cardiac problems, glaucoma,
· high fever in children: loss of transpiration, risk of hyperpyrexia, anoxia, convulsions, cardio-respiratory arrest.

- May cause: dry mouth, constipation, dizziness, headache.
- Do not combine with chlorpromazine or promethazine.
- Do not use for minor symptoms.
- Pregnancy: avoid, particularly in the third trimester of pregnancy, NO PROLONGED TREATMENTS
- Lactation: avoid, NO PROLONGED TREATMENTS

Remarks

- Storage: no special temperature requirements.

KETAMINE (Ketalar(R), Ketanest((R).)

District hospital

Therapeutic action

- General anaesthetic

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- General anaesthesia for short interventions

Preparation and route of drug administration

- Ampoule of 10 mg/ml (5 ml and 20 ml) for IM or IV injection or infusion of 50 mg/ml (5 ml and 10 ml) for IM or IV injection or infusion of 100 mg/ml (5 ml) for IM or IV injection or infusion

Dosage

- Child and adult

· IV : 2 mg/kg injected slowly over 1 to 2 minutes. The anaesthesia lasts for 5 to 10 minutes
· IM: 10 mg/kg in deep IM over 3 to 4 minutes. The anaesthesia begins after 10 minutes and lasts for 12 to 25 minutes.

Duration: depending on the duration of the intervention

To prolong the anaesthesia, repeat with half dose injection.

Contra-indications, side-effects, precautions

- Do not administer if:

· arterial hypertension, intracranial or intraocular pressure
· renal or heart failure or pre-eclampsia.

- Risk of hypertension, hallucinations on waking (less frequent with children or when injected IM).
- Use with care for obstetric cases: passes the placenta barrier.
- Give atropine premedication to prevent hypersalivation and vagal reactions.
- Use diazepam as premedication.
- Always have resuscitation and respiratory equipment available and ready for use.
- Pregnancy: no contra-indication, except in case of pre-eclampsia; with caesarian sections, there is a risk of the newborn having respiratory problems.
- Lactation: no contra-indication

Remarks

- Do not mix in the same syringe with barbiturates (thiopentone, phenobarbitone).
- Ketamine has no muscle relaxant properties.
- In certain countries, ketamine is on the list of narcotics. In that case, follow the national rules for imports, handling and storage.
- Storage: no special temperature requirements

LIGNOCAINE = LIDOCAINE (Xylocaine(R), Xylocard(R).)

District hospital

Therapeutic action

- Local anaesthetic

Indications

- Local anaesthesia:

· suturing, whitlow (= panaris): solution of 1%.
· dental care: solution of 2%, (with or without adrenaline)

Preparation and route of drug administration

- Solution of 1% (10 mg/ml), vials of 20 and 50 ml, for SC injection (and infusion)
- Solution of 2%, (20 mg/ml), vials of 20 and 50 ml, for SC injection (and infusion)

Dosage

- The volume to be injected depends on the surface area to be anesthetized.
- Do not exceed:

Child: 5 mg/kg/injection
Adult: 200 mg = 20 ml solution of 1% or 10 ml solution of 2%

FIGURE

Duration: single injection, to be repeated if necessary

Contra-indications, side-effects, precautions

- Do not administer if known allergy to lignocaine, problems of blood coagulation or impairment of cardiac conduction.
- Lignocaine with adrenaline:

· In dental care, adrenaline added to lignocaine prolongs the anaesthesia.
· Do not administer solutions containing adrenaline for the anaesthesia of the extremities (fingers, penis): risk of ischemia and necrosis.

- When anaesthetizing the extremities, inject distally (at the root), in circle, without tourniquet and without adrenaline.
- Do not use lignocaine for the incision of abscesses: risk of spreading the infection.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- The anaesthesia sets in after 2 to 5 minutes and lasts 1 to 1.5 hours.
- Preferably use lignocaine 2% for dental applications.
- Do not confuse with lignocaine 5% hyperbaric which is reserved for spinal anaesthesia.
- The more concentrated the lignocaine, the more localised the anaesthetic effect.
- To simplify the protocol, choose lignocaine 2% with adrenaline for dental use and lidocaine 1% without adrenaline for skin anaesthesia.
- Storage: keep below 30°C.

LIGNOCAINE Hyperbaric = LIDOCAINE Hyperbaric (Xylocaine(R) of 5% for spinal anaesthesia)

Special department

Therapeutic action

- Local or regional anaesthetic

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Spinal anaesthesia = injection in the cerebro-spinal fluid: anaesthesia for the surgery of the lower limbs and the lower abdomen (below the umbilicus)

Preparation and route of drug administration

- Ampoule of 100 mg (50 mg/ml, 2 ml, equals 100 mg lignocaine in a hyperbaric glucose solution), for injection in the cerebro-spinal fluid

Dosage

According to the weight of the patient:

- Adult (shorter than 1.55 m): 50 to 75 mg
- Average adult : 100 mg
- Heavy adult : 150 mg

FIGURE

Duration: the anaesthesia sets in after 2 to 3 minutes and lasts 90 minutes

Contra-indications, side-effects, precautions

- Spinal anaesthesia should not be applied if there is no proper intubation and respiratory equipment.
- Do not administer in cases of :

· shock,
· disease of the central or peripheral nervous system,
· septicemia, meningitis,
· coagulation problems; severe haemorrhages, skin infection near the place of injection,
· known allergy to local anaesthetics.

- May cause:

· hypotension which should be prevented by the administration of a 500 ml ringer lactate infusion before spinal anaesthesia,
· nausea, vomiting, often linked to hypotension,
· sometimes urine retention,
· frequent headache after surgery.

- Use spinal anaesthesia only for adults.
- Before anaesthesia, the patient should be premedicated with atropine.
- Before spinal anaesthesia, the patient should be very well hydrated with ringer lactate or isotonic sodium chloride (500 ml). There should be good venous access, and the arterial pressure should be strictly monitored.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Lignocaine hyperbaric is strictly reserved for spinal anaesthesia.
- Storage: keep below 30°C.

METAMIZOL = DIPYRONE = NORAMIDOPYRINE (Nolotil(R), Novalgin(R), Novaminsulfon(R).)

RESERVE THIS DRUG FOR SERIOUS SITUATIONS WHERE NO OTHER TREATMENT IS POSSIBLE:

- it is potentially dangerous;
- it is not included in the WHO essential drug list;
- its marketing is forbidden in several countries;
- its use is never justified as a first-line treatment.

District hospital

Therapeutic action

- Analgesic
- Antipyretic

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Severe pain
- High fever

Preparation and route of drug administration

- Ampoule of 1 g (500 mg/ml, 2 ml) for IM, SC or slow IV injection or infusion

Dosage

- Child: 10 mg/kg/injection
- Adult: 500 mg/injection

FIGURE

Duration: depending on clinical progress

Contra-indications, side-effects, precautions

- Do not administer if gastric ulcer.
- SEVERE AND LETHAL CASES OF AGRANULOCYTOSIS HAVE BEEN FOUND. THE RISK IS UNPREDICTABLE AND INDEPENDENT OF THE DOSE ADMINISTERED.
- Pregnancy: avoid
- Lactation: avoid

Remarks - Storage: no special precautions.

METOCLOPRAMIDE (Anausin(R), Maxolon(R), Primperan(R), Reglan(R).)

District hospital

Therapeutic action

- Anti-emetic

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Vomiting

Preparation and route of drug administration

- Ampoule of 10 mg (5 mg/ml, 2 ml) for IM or slow IV injection

Dosage

- Adult: 5 to 10 mg/injection 1 to 3 times per day, IM or slow IV injection

FIGURE

Duration: depending on clinical evolution, as short as possible

Contra-indications, side-effects, precautions

- Contra-indicated in case of gastro-intestinal haemorrhage, obstruction or perforation.
- In case of elevated doses or prolonged treatments, risk of extrapyramidal disorder (agitation and spasms), specially in young patients.
- Increase of crisis for epileptics and those suffering from Parkinson's disease.
- Reversible methaemoglobinemia in newborns.
- Association with propanthelin, hyoscine, atropine and chlorpromazine is not advised.
- Risk of drowsiness.
- Pregnancy: no contra-indication
- Lactation : avoid

Remarks

- It is most important to treat the cause of vomiting; look for bowel obstruction or malaria.
- Storage: keep below 30°C.

OXYTOCIN (Pitocin(R), Syntocinon(R).)

District hospital

Therapeutic action

- Uterotonic

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Induction of delivery on medical indication

Preparation and route of drug administration

- Ampoule of 5 IU (5 IU/ml, 1 ml) for injection in infusion
- Ampoule of 10 IU (10 IU/ml, 1 ml) for injection in infusion

Dosage

- 1 to 5 IU diluted in 500 ml isotonic solution in a very slow infusion :2 to 4 drops a minute. Increase the dose progressively until the contractions are normal: maximum 40 drops a minute.

Duration: depending on clinical progress

Contra-indications, side-effects, precautions

- Do not administer if:

· hypertonia of the uterus,
· fragile uterus: former caesarian section,
· placenta praevia,
· pre-eclampsia.

- The cervix of the uterus should be dilated (3 to 4 cm) and effacing.
- The foetal membranes should be ruptured.
- The foetus must be monitored throughout, since there is a risk of fetal distress.

Remarks

- If not contra-indicated, preferably use (methyl)-ergometrine for uterine atonies and postpartum haemorrhage.
- Storage: refrigerated

Do not freeze.

PENTAZOCINE (Fortal(R).)

District hospital

Therapeutic action

- Central analgesic (opioid analgesic)

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Severe pains not responding to other analgesics

Preparation and route of drug administration

- Ampoule of 30 mg (30 mg/ml, 1 ml) for IM, slow IV or SC injection, infusion or rectal administration

Dosage

- Child (above 3 years): 0.5 mg/kg/injection for slow IV injection 1 mg/kg/injection for IM or SC injection
- Adult: 30 to 60 mg/injection, repeat every 3 to 4 hours if necessary

FIGURE

Duration: depending on indications and clinical progress

Contra-indications, side-effects, precautions

- Do not administer if:

· liver impairment,
· respiratory depression,
· head injury.

- May cause: sedation, dizziness, hypotension, respiratory depression.
- Prolonged treatment can cause addiction.
- Signs of overdose: respiratory depression, hypotension, hypothermia.
- Pregnancy :avoid
- Lactation: avoid

Remarks

- In some countries, pentazocine is on the list of narcotics. In that case, follow the national rules for imports, handling and storage.
- Storage: keep cool.

PHENOBARBITONE = PHENOBARBITAL (Gardenal(R), Luminal(R).)

District hospital

Therapeutic action

- Anticonvulsive, sedative and hypnotic

Indications

- Epilepsy: tonic-clonic ("grand mal") and partial (focal) seizures

Preparation and route of drug administration

- Ampoule of 200 mg (100 mg/ml, 2 ml) for deep IM or slow IV injection

Dosage

- Child and adult: 3 to 5 mg/kg/d (maximum 200 mg/d)
- Do not exceed indicated doses.

Duration: depending on clinical progress; change to oral treatment as soon as possible

Contra-indications, side-effects, precautions

- Do not administer in case of respiratory depression.
- Depresses the central nervous system: drowsiness, respiratory depression.
- Risk of sedation when combined with alcohol and other drugs that act on the central nervous system: diazepam (Valium(R)), chlorpheniramine (Teldvin(R)) and chlorpromazine (Largactil(R)).
- Pregnancy: avoid (refer to a doctor)
- Lactation: no contra-indication

Remarks

- For convulsions, in cases of extreme agitation and in emergencies, it is better to use diazepam (Valium(R)).
- Phenobarbitone should be injected in glass syringes; if not available, inject immediately after filling the syringe.
- Do not mix phenobarbitone with other drugs in the same syringe.
- Storage: no special temperature requirements.

PHYTOMENADIONE = VITAMIN K1 (Konakion(R).)

District hospital

Therapeutic action

- Vitamin

Indications

- Haemorrhagic disease of the newborn: treatment and prevention.
- Haemorrhage in patients subject to an anti-coagulant treatment (anti-vitamin K).
- Lack of vitamin K.
Vitamin K has no immediate haemostatic action: it is not indicated in cases of haemorrhagia of traumatic origin. Its therapeutic indications are very limited since vitamin K1 deficiency is rarely seen.

Preparation and route of drug administration

- Ampoule of 1 mg/ml, 1 ml for oral, IM or IV injection

Dosage

- Haemorrhagic disease of the newborn: oral

· prevention: 1 mg in a single dose at birth
· treatment : 1 mg/d x 7 days

- Prophylaxis and treatment of lack of vitamin K: 10 to 20 mg/IM injection
- Haemorrhagia due to anti-vitamin K: 10 to 20 mg/slow IV injection

Duration

Contra-indications, side-effects, precautions

- Injectable administration is contra-indicated in newborn and infants.
- Risk of haematoma at IM injection point.
- Risk of allergic reactions by IV injection.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Vitamin K should not be mixed with another medicine.
- Use glass syringe.
- Storage:

PROCAINE PENICILLIN = PROCAINE BENZYL PENICILLIN = PROCAINE PENICILLIN G

District hospital

Therapeutic action

- Antibacterial (antibiotic) with prolonged action (24 hours)

Indications

- Pneumonia
- Gonorrhoea
- Anthrax
- Prophylaxis of septicemia following abortion

Preparation and route of drug administration

- Vial of powder of 3 M IU procaine penicillin for IM injection, NEVER IV injection or infusion After diluting the powder with distilled water, the suspension has to be shaken before it can be used.

Dosage

- Child : 50,000 to 100,000 IU/kg/d
- Adult: 1 to 4 M IU/d

FIGURE

Duration

- Gonorrhea: single dose divided between each buttock. COMBINE WITH A DOSE OF 1 G PROBENECID TABLETS at the time of injection.
- Other indications: 5 days minimum.

Contra-indications, side-effects, precautions

- Do not administer if known allergy to penicillin.
- If allergic reaction, stop treatment and refer to a doctor.
- For children under 1 year, administer with care: risk of convulsions and allergies caused by the procaine.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Procaine penicillin is penicillin G bound to procaine, which gives it an action lasting for 24 hours.
- 1 g procaine penicillin equals 1 M IU penicillin.
- Procaine penicillin is replaced in some countries by a mixture of procaine penicillin and penicillin G (3 + 1 M IU), often called procaine penicillin forte (PPF) which has the advantage of the immediate action of penicillin G, followed by the delayed action of procaine penicillin.
- Penicillin benethamine (Bi-clinocilline(R)) has a prolonged action (2 to 3 days): administer every other day.
- In case of gonorrhea, ALWAYS TREAT THE PARTNER AS WELL.
- Storage: keep below 30°C.
After preparation, the suspension must be used within 24 hours.

PROCAINE BENZYL PENICILLIN + BENZYL PENICILLIN = PROCAINE PENICILLIN FORTE = PPF (Bicillin(R).)

District hospital

Therapeutic action

- Antibacterial (antibiotic) with double action prolonged (24 hours) by the procaine penicillin and immediate by the benzyl penicillin

Indications

- Pneumonia
- Gonorrhoea
- Anthrax
- Prophylaxis of septicemia following abortion

Preparation and route of drug administration

- Vial of powder of 3 M IU procaine penicillin + 1 M IU benzyl penicillin (penicillin G) for IM injection, NEVER IV injection or infusion. After diluting the powder with distilled water, the suspension has to be shaken before it can be used.

There are also vials of 600,000 IU procaine penicillin + 300,000 IU benzyl penicillin.

Dosage

- Child: 50,000 to 100,000 IU/kg/d
- Adult: 1 to 4 MIU/d

FIGURE

Duration

- Gonorrhea: single dose divided between each buttock. COMBINE WITH A DOSE OF 1 G PROBENECID TABLETS at the time of injection.
- Other indications :5 days minimum.

Contra-indications, side-effects, precautions

- Do not administer if known allergy to penicillin.
- If allergic reaction, stop treatment and refer to a doctor.
- For children under 1 year, administer with care: risk of convulsions and allergies caused by the procaine.
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Compared to procaine penicillin, PPF has the advantage of the immediate action of penicillin G, and 24 hours action of procaine penicillin.
- In case of gonorrhea, ALWAYS TREAT THE PARTNER AS WELL.
- Storage: keep below 30°C.

After preparation, the suspension must be used within 24 hours.

PROMETHAZINE (Phenergan(R).)

District hospital

Therapeutic action

- Anti-emetic
- Antihistaminic
- Sedative

Indications

- Vomiting
- Allergic reactions due to:

· contact, seasons.
· drugs, insect bites, food.

Preparation and route of drug administration

- Ampoule of 50 mg (25 mg/ml, 2 ml) for IM or IV injection or infusion

Dosage

- Child: 1 mg/kg/d
- Adult: 25 to 100 mg/d

FIGURE

Duration: depending on clinical progress; change to oral treatment as soon as possible

Contra-indications, side-effects, precautions

- Risk of drowsiness.
- Risk of sedation when combined with alcohol and other drugs that act on the central nervous system: diazepam (Valium(R)), phenobarbitone (Gardenal(R)), chlorpromazine (Largactil(R)) and chlorpheniramine (Teldvin(R)).
- In case of anaphylactic shock: use adrenaline and/or corticoid-steroids.
- Pregnancy: avoid in the first 3 months of the pregnancy and in the perinatal period
- Lactation: no contra-indication

Remarks

- The use of promethazine as an anti-emetic can mask the symptoms of the causal disease. Do not use for convenience.
- Storage: keep below 30°C.

QUININE Salts

District hospital

Therapeutic action

- Antimalarial

Indications

- Plasmodium falciparum malaria, pernicious attack, when the patient cannot take oral treatment: cerebral malaria (coma), convulsions, vomiting and diarrhoea

Preparation and route of drug administration

- Ampoules of 200 mg (100 mg/ml, 2 ml), 300 mg (150 mg/ml, 2 ml) and 600 mg (300 mg/ml, 2 ml) for infusion

There are also other doses. Adapt dosage accordingly. IM injection is possible, but only when absolutely necessary because there are numerous complications: paralysis of sciatic nerve, muscular necrosis, infections.

Dosage

- Child and adult: 30 mg/kg/d in slow infusion divided in 3 infusions of 10 mg/kg in 500 ml glucose 5% administered slowly (4 hours or 40 drops/minute)

FIGURE

Doses and dosages are expressed in salts. They are all equal: formiate or bi-chlorhydrate (quinine dihydrochloride).

Duration

- One day or more until oral treatment is possible: change to quinine or chloroquine tablets according to national protocol.

Contra-indications, side-effects, precautions

- Possible allergic reactions.
- Never inject in direct IV, always dilute: risk of cardiac depression. Infuse slowly. Do not combine with chloroquine.
- Signs of overdose: obvious hearing and visual disturbances.
- If shock or renal failure: halve the dose.
- If convulsions, combine with diazepam (Valium(R)).
- Pregnancy: no contra-indication (do not exceed the therapeutic doses)
- Lactation: no contra-indication

Remarks

- In some regions of South-East Asia, the combination of quinine + tetracycline (25 mg/kg/d) or doxycycline (10 mg/kg/d orally) for 10 days is necessary because of resistance.
- Storage: keep below 30°C.

SALBUTAMOL = ALBUTEROL (Salbulin(R), Salbutan(R), Ventolin(R).)

District hospital

Therapeutic action

- Bronchodilator
- Uterorelaxant

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Treatment of severe asthmatic crisis and of status asthmaticus
- Emergency treatment of threatening premature delivery, except in case of toxemia or haemorrhage

Preparation and route of drug administration

- Ampoule of 0.5 mg/ml, 1 ml for SC, IM injection or infusion

Dosage

- Asthma

Adult: 0.5 mg SC or IM to be repeated every 4 to 6 hours if necessary

- Threatening premature delivery

· Emergency treatment: 5 mg (10 ampoules) in infusion, diluted in 500 ml of dextrose; approximately 30 to 40 drops/minute, to be progressively increased until contractions stop, then decrease dosage. Injectable salbutamol should only be used under strict medical surveillance, with regular checking of the pulse, blood-pressure and the fœtal heart rate.
· Maintenance dose: 2 mg/d divided in 4 IM injections; change to oral medication as soon as possible.

Duration: depending on clinical progress

Contra-indications, side-effects, precautions

- Do not administer to children.
- Do not administer in cases of myocardial infarction and acute coronary insufficiency.
- Administer with care to patients with cardiac insufficiency, arrhythmia, high bloodpressure, haemorrhage, diabetes, hyperthyroidism.
- May cause: tachycardia, trembling, dizziness, headache.
- Do not use with beta-blocking agents (propranolol).
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- Storage: keep below 30°C.

STREPTOMYCIN

Special department

Therapeutic action

- "Antituberculous" antibacterial (antibiotic)

Indications

- Only for tuberculosis, bacteriologically proven if possible

Preparation and route of drug administration

- Vials of powder of 1 g and 5 g (base) to be diluted respectively in 5 or 10 ml sterile water, for IM injection, NEVER IV injection of infusion.

Dosage

According to national protocol.

For information:

- Child: 20 mg (base)/kg/d in 1 injection
- Adult: 750 mg to 1 g/d depending on the weight of the patient, in 1 injection
- Do not exceed a total dose of 60 g because of the oto-toxicity of streptomycin.

Duration: according to national protocol (generally 2 months)

Contra-indications, side-effects, precautions

- Do not administer if severe renal failure.
- Stop treatment if dizziness, buzzing of ears, hearing loss.
- Pregnancy: CONTRA-INDICATED
- Lactation: CONTRA-INDICATED

Remarks

- Streptomycin is also used for the treatment of plague and brucellosis. Other antibacterials are active against these diseases. Reserve this drug for the treatment of tuberculosis.
- Warning: antituberculous treatment should only be prescribed in the context of an organised program (well established protocol, regular patient checks and the possibility of laboratory examination).
- Streptomycin should not be used alone, but in combination with other "antituberculous" drugs to avoid resistance.
- Storage: keep cool.

After preparation, the solution must be clear and can be kept for only one hour.

SULFADOXINE + PYRIMETHAMINE (Fansidar(R).)

Therapeutic action

- Antimalarial

Indications

- Treatment of Plasmodium falciparum malaria resistant to chloroquine and other amino-4 quinolines (amodiaquine(R).)

Preparation and route of drug administration

- Ampoule of 400 mg sulfadoxine + 20 mg pyrimethamine (200 mg sulfadoxine + 10 mg pyrimethamine/ml, 2 ml) for IM injection or infusion

Dosage

- Child: 25 mg/kg sulfadoxine in a single dose for IM injection or infusion (1/2 amp./10 kg)
- Adult: 800 ma sulfadoxine in a single dose for IM injection or infusion
- Never give in direct IV, always dilute.

FIGURE

Duration: single dose

Contra-indications, side-effects, precautions

- Do not administer if:

· allergy to sulfonamides,
· renal or liver failure.

- May cause: gastro-intestinal problems, nausea, vomiting, sometimes severe allergic reactions.
- Do not combine with chloroquine.
- Avoid for children under 5 years.
- Pregnancy: CONTRA-INDICATED
- Lactation: avoid

Remarks - Preferably use injectable quinine.

- Warning: there is an increasing number of resistant strains.
- Storage: no special precautions

THIOPENTONE sodium = THIOPENTAL sodium = PENTOBARBITAL sodium (Pentothal(R).)

Special department

Therapeutic action

- Anaesthetic
- Anticonvulsive

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Induction of general anaesthesia
- Anaesthesia of short duration (not more than 15 minutes)
- This drug has no analgesic action and is not a muscle relaxant

Preparation and route of drug administration

- Vials of powder of 0.5 g or 1 g for IV injection, to be dissolved in a glucose 5% solution or in 0.9% NaCl solution (0.5 g in 20 ml)

Dosage

- Dose:

· average :1 to 10 mg/kg
· total maximum :1 g

- Induction of anaesthesia: test dose 50 mg, afterwards 100 to 200 mg in 20 seconds
- Lower dose for elderly patients.

Duration: depending on duration of the intervention

Contra-indications, side-effects, precautions

- Use only if intubation and ventilation equipment are available.
- Do not administer in cases of shock.
- Do not administer to ambulatory patients or to children under 4 years.
- May cause:

· apnoea, laryngospasm, bronchospasm,
· initial bloodpressure drop.

- Possible depression of circulation and respiration if overdose.
- Risk of pain and necrosis if extravenous or intra-arterial injection.
- Use with care in cases of asthma, heart failure, liver, renal or severe adrenal insufficiency, porphyria, myasthenia.
- The anaesthesia has to be preceded by a premedication with atropine and, if necessary, with analgesics and muscle relaxants.
- Pregnancy: use with care near term (causes foetus to sleep)
- Lactation :avoid

Remarks

- The concentration should not exceed 2.5% due to risk of thrombo-phlebitis.
- Do not mix with another injectable drug, nor with ringer lactate.
- Storage: keep cool.

After preparation, the solution can be kept for up to 24 hours if kept cool.

Infusion solutions and Electrolytes

Use of infusion solutions
Dextran
Dextrose - Glucose
Half Strength Darrow's solution
Polygeline
Potassium chloride
Ringer lactate (Hartmann)
Sodium bicarbonate
Sodium chloride

Use of infusion solutions

Choice of infusion solutions according to the indications

There is no justification for using more than 3 kinds of infusion solution:

- one kind for IV rehydration (ringer lactate is the most suitable);
- one kind for dilution of IV injectable drugs (isotonic dextrose solution is the most suitable);
- one kind for fluid replacement (best choice is polygeline).

FIGURE

Precautions for the use of infusion solutions

- Read the labels on the infusion bottle (or bag) well to avoid mistakes.
- Indicate on the label any drugs added to the infusion.
- If drugs are added in a vial, think of the risks of:

· physical or chemical incompatibility,
· contamination: strict asepsis.

- Inspect each bottle against the light to check its clarity: discard any bottles that show particles in suspension.

DEXTRAN (Macrodex(R), Rheomacrodex(R))
solution for INFUSION

District hospital

Preparation

- Bottle of 500 ml

Composition

- Dextran 40,000 or 70,000 (composition and concentration varies with manufacturer) in a sorbitol, glucose, NaCI or ringer lactate solution

Indications

- Restoring macromolecules and maintaining the blood pressure and volume. Fluid replacement in case of hypovolemic shocks: trauma, surgery and sepsis.

Contra-indications, side-effects, precautions, remarks

- Risk of inducing renal failure: do not exceed 1000 ml for an adult and/or 500 ml/d if the treatment has to be prolonged.
- Risk of haemostatic disorder.
- Risk of allergy.
- In case of dehydration, correct electrolyte imbalance.
- Draw blood for type and cross-match before infusing.
- Do not mix other drugs in the infusion solution.
- Storage: keep below 30°C, but over 4°C.
The solution must be clear.

DEXTROSE 5% = GLUCOSE 5%
isotonic solution in INFUSION

District hospital

Preparation

- Bottle/bag of 500 ml of 5%
- Bottle/bag of 1 litre of 5%

Composition

- Isotonic solution: dextrose 5 g per 100 ml

Indications

- Infusion medium
- Intra-cellular dehydration (rare): fevers, sunstroke

Contra-indications, side-effects, precautions, remarks

- This solution contains no electrolytes or lactate. Therefore it is not recommended for the treatment of dehydration. Preferably use ringer lactate. If this is not available, take a solution of dextrose 5% and add KCI (2 g/l) + NaCI (4 g/l).
- The solutions of dextrose 5% 1/2, 1/3 or 1/4 salted have the same indications and inconveniences as the isotonic NaCI solution.
- Do not confuse with the 10%, 15%, 30% and 50% hypertonic solutions.
- Storage: keep below 30°C

DEXTROSE 30 or 50% = GLUCOSE 30 or 50%
hypertonic solution in AMPOULE

District hospital

Preparation

- Ampoule of 10 ml of 30% or 50%

There are also ampoules of 20 ml and bottles of 50 ml, 500 ml

Composition

- Hypertonic solution: dextrose 30% = 3 g/10 ml dextrose 50% = 5 g/10 ml

Indications

- Energy supplementation (1 g dextrose provides 4 calories)
- Hypoglycaemia

Contra-indications, side-effects, precautions, remarks

- Do not administer hypertonic solution IM or SC. The injections must be given in slowly direct IV injection or in IV infusion.
- Storage: keep below 30°C

Half Strenght DARROW'S SOLUTION
solution for INFUSION

District hospital

Preparation

- Bottle/bag of 500 ml
- Bottle/bag of 1 litre

Composition

- Varies with manufacturer. Example (ionic composition per litre):
Sodium (Na+) : 61 mmol = 61 mEq
Potassium (K+) : 18 mmol = 18 mEq
Chloride(Cl-) : 51 mmol = 51 mEq
Bicarbonate : 27 mmol = 27 mEq

Indications

- Severe dehydration

Contra-indications, side-effects, precautions, remarks

- Isotonic solution without providing calories.
- This solution has the disadvantage of not providing enough NaCl, but the advantage of providing suitable quantities KCI. For prolonged use, double the amount or add 10% or 20%, NaCl by ampoule in order to obtain sufficient concentrations (1 ampoule per litre = 1 to 2 g NaCl).
- Preferably use ringer lactate when available.
- There are also hypertonic solutions.
- Storage: keep below 30°C

POLYGELINE (Hcel(R).)
solution for INFUSION

District hospital

Preparation

- Bottle of 500 ml

Composition

- Varies with manufacturer. Example (ionic composition per litre):

	Haemacel(R)
Polygeline	35 g/l
Sodium (Na+)	145.00 mmol = 145.00 mEq
Potassium (K+)	5.10 mmol = 5.10 mEq
Calcium (Ca++)	6.25 mmol = 12.50 mEq
Chloride (Cl-)	145.00 mmol = 145.00 mEq
Magnesium (Mg++)	----

Indications

- Fluid replacement in cases of hypovolemic shock: trauma, surgery and sepsis.

Contra-indications, side-effects, precautions, remarks

-This solution combines replacement of electrolytes and macromolecules. It has almost no effect on haemostasis.
-Administer 1 or 2 bottles on average. Adapt dosage according to the needs of the patient.
-In case of haemorrhagic shock, infuse one after the other. If polygelines are not availabe, use ringer lactate, giving three times the lost volume.
-For other forms of shock, infuse quickly until a good pulse reappears.
-Risk of allergy.
-Draw blood for type and cross-match before infusing.
-Do not dilute other drugs into this type of infusion.
Storage: stable between 18°C and +50°C.
Usable after freezing.

POTASSIUM Chloride 10%
hypertonic solution in AMPOULE

District hospital

Preparation

- Ampoule of 10 ml of 10% = 1 g KCI per ampoule
- Ampoule of 20 ml of 10% = 2 g KCl per ampoule

There are also ampoules of 10 ml and 20 ml of 7.5%, 15% and 20%. Adapt dosage accordingly.

Composition

Potassium chloride: 10 g per 100 ml

- Hypertonic solution
- Ionic composition:

potassium (K+):	13.4 mmol per ampoule of 10 ml (13.4 mEq)
	26.8 mmol per ampoule of 20 ml (26.8 mEq)
chloride (Cl-):	13.4 mmol per ampoule of 10 ml (13.4 mEq)
	26.8 mmol per ampoule of 20 ml (26.8 mEq)

Indications

- Treatment and prevention of hypokalemia

Contra-indications, side-effects, precautions, remarks

- Do not administer hypertonic solution IM or SC. Administer slowly as direct IV injection or infusion (in dextrose 5%).
- Risk of ventricular rhythm problems if injected too quickly : do not exceed 2 to 3 g KCl/hour.
- If ringer lactate is not available, take a 5% solution of dextrose and add KCl (2 g/l) + NaCl (4 g/l)
- Storage: no special precautions

RINGER LACTATE = COMPOUND SODIUM LACTATE SOLUTION = Hartmann's solution
isotonic solution for INFUSION

District hospital

Preparation

- Bottle/bag 500ml
- Bottle/bag 1 litre

Composition

- Varies with manufacturer
- Most usual ionic composition per litre:
Sodium (Na+) : 130.50 mmol = 130.50 mEq
Potassium (K+) : 4.02 mmol = 4.02 mEq
Calcium (Ca++) : 0.67 mmol = 1.35 mEq
Chloride (Cl-) : 109.60 mmol = 109.60 mEq
Lactate : 28.00 mmol = 28.00 mEq

Indications

-Severe dehydration

Contra-indications, side-effects, precautions, remarks

-Isotonic solution without providing calories.
-Ringer lactate provides appropriate quantities of electrolytes. It contains lactate which transforms into bicarbonate in the body and corrects metabolic acidosis if it exists (if haemodynamic and liver function are normal). WARNING, SOME COMMERCIALLY AVAILABLE SOLUTIONS DO NOT CONTAIN LACTATE.
-It does not contain much KCl (5 mEq/litre), but sufficient for short term use. For prolonged use (after 2 to 3 days), a supplement of potassium is necessary. Add 1 or 2 g KCl per litre = 1 to 2 ampoules of 10 ml KCl 10%/litre.
-For moderate and mild dehydration, administer ORS (Oral Rehydration Salts).
-This solution can be used for haemorrhagic shock. In that case, 3 times the lost volume has to be infused.
Storage: keep below 30°C

SODIUM Bicarbonate 1.4%
isotonic solution for INFUSION

District hospital

Preparation

- Bottle/bag 500 ml

Composition

Sodium bicarbonate :1.4 g per 100 ml

- Isotonic solution
- Ionic composition per litre:

Sodium (Na+): 167 mmol = 167 mEq

Bicarbonate 167 mmol = 167 mEq

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Severe metabolic acidosis

Contra-indications, side-effects, precautions, remarks

- Do not use in case of metabolic alkalosis or respiratory acidosis.
- Contains a high concentration of bicarbonate and sodium ions. This is seldom justified in the case of metabolic acidosis caused by dehydration. Poor monitoring of use may induce hypernatremia and hypokalemia.
- Do not mix in the same infusion: penicillin, chloramphenicol, aspirin, atropine, calcium, insulin, vitamins.
- Storage: keep below 30°C

SODIUM Bicarbonate 8.4%
hipertonic solution in AMPOULE

District hospital

Preparation

- Ampoule of 10 ml or 20 ml

Composition

Sodium bicarbonate: 8.4 g per 100 ml

- Hypertonic solution
- Ionic composition:
Sodium (Na+): 10 mmol = 10 mEq per ampoule of 10 ml
Bicarbonate : 10 mmol = 10 mEq per ampoule of 10 ml

Indications PRESCRIPTIONS AND FOLLOW-UP OF TREATMENT MUST BE UNDER MEDICAL SUPERVISION

- Severe metabolic acidosis

Contra-indications, side-effects, precautions, remarks

- Do not administer hypertonic solutions IM or SC. Administer under strict medical supervision, slowly direct IV injection or infusion (in dextrose 5%).
- Do not use in case of alkalosis or respiratory acidosis.
- Contains a high concentration of bicarbonate and sodium ions. This is seldom justified in the case of metabolic acidosis caused by dehydration. Poor monitoring of use may induce hypernatremia and hypokalemia.
- Do not mix in the same infusion: penicillin, chloramphenicol, aspirin, atropine, calcium, insulin, vitamins.
- Storage: keep below 30°C

SODIUM Chloride 0.9% = NaCl physiological salt = normal saline
isotonic solution for INFUSION

District hospital

Preparation

- Bottle/bag of 500 ml or 1 litre of 0.9%

There are also ampoules of different volumes.

Composition
Sodium chloride :0.9 g per 100 ml

- Isotonic solution
- Ionic composition: Sodium (Na+) : 154 mmol per litre (154 mEq)
Chloride (Cl-) : 154 mmol per litre (154 mEq)
Indications
- Infusion medium (administration of drugs, instant venous access)

Contra-indications, side-effects, precautions, remarks

- Do not use in case of water-salt retention, heart failure, oedema and ascites due to cirrhosis.
- This solution contains neither lactate nor potassium. Its use is therefore not recommended for the treatment of severe dehydration. Preferably use ringer lactate.
- If ringer lactate is not available, take a 5%, solution of dextrose and add KCI (2 g/l) + NaCl (4 g/l).
- Storage: keep below 30°C

SODIUM Chloride = NaCl
hypertonic solution in AMPOULE

District hospital

Preparation

- Ampoules of 10 ml or 20 ml of 10% and 20%

Composition
Sodium bicarbonate: 10 g per 100 ml and 20 g per 100 ml

- Hypertonic solution
- Ionic composition:
Sodium (Na+) : 1.7 mmol per litre (1.7 mEq), solution 10%
3.4 mmol per litre (3.4 mEq), solution 20%
Chloride (Cl-): 1.7 mmol per litre (1.7 mEq), solution 10%
3.4 mmol per litre (3.4 mEq), solution 20%

Indications

- Hyponatremia

Contra-indications, side-effects, precautions, remarks

- Do not administer hypertonic solutions IM or SC. Administer slowly direct IV injection or IV infusion.
- Do not use in case of water-salt retention, heart failure, oedema and ascites due to cirrhosis.
- Storage: keep below 30°C

Vaccines and sera

Antiamaril vaccine
Antimeningococcal vaccine A + C
Antitetanic serum
BCG vaccine
DPT vaccine
Measles vaccine
Oral antipoliomyelitis vaccine
Tetanus vaccine

Vaccines and sera are sensitive products to heat and light. Even if new productions give vaccines more stable to heat (called "thermostable"), they still have to be stocked in the refrigerator between 0 and 8°C, and cold chain strictly have to be respected during transport.

Information mentioned hereafter concerning stability only helps to decide if vaccines stocked during a short time at a temperature superior to 8°C could be used or have to be destroyed.

ANTIAMARIL VACCINE (Stamaril, Amarela)

Health clinic

Indications

- Prevention of yellow fever
- Must be integrated in the national Expanded Program of Immunization (EPI)

Presentation and route of drug administration

- Live attenuated viral vaccine, freeze-dried powder to be diluted with a special solvent. There are vials of powder for 10 doses, 20 doses and 50 doses, with the vials of solvent.
- Administration in deep subcutaneous or IM injection in the deltoid muscle of the arm.

Dosage and vaccination scheme

- Child and adult :0.5 ml
- May be administered as of the age of 6 months (4 months during epidemics)
- Efficiency: after 10 days for 10 years

Contra-indications, side-effects, precautions

- Contra-indicated in case of immunodeficiency and genuine allergy to eggs.
- Local reaction possible in 20% of the cases.
- Fever and myalgia 4 to 10 days after the injection in 5 to 10% of the cases.
- Complications:

· neurological reactions (encephalitis),
· allergic reactions: erythema, urticaria, oedema (1 case in 1 million doses).

- Pregnancy: this vaccine can be administered to pregnant women only if there is a major risk of infection (epidemic)
-Lactation: no contra-indication

Remarks

- It is always better to use the solvent delivered with the vaccine. In case of loss, we recommend sodium chloride 0.9% or water for injection as the solvent, using the same quantity as the solvent delivered.
- Combinations

· Simultaneous combination (at the same time, in a separate syringe)
Compatible with other vaccines given by EPI; contra-indicated with cholera and typhoid A and B.
· Combinations with other vaccines (in the same syringe)
Possible with measles vaccine.

- Storage

· Freeze-dried powder
Store between O and 8°C. Freezing (-20°C) recommended for long periods. At 37°C, freeze-dried vaccine is stable for 7 to 14 days.
· After dilution
Between O and 8°C, the vaccine is stable for 3 hours; at 37°C, it becomes unefficient in less than 1 hour. This vaccine is one of the most sensitive to heat. At the moment of dilution, the solvent must be at the same temperature as the vaccine (0 to 8°C).

ANTIMENINGOCOCCAL VACCINE A + C

Health clinic

Indications

- Prevention of meningococcal meningitis type A and C

Presentation and route of drug administration

- Polysaccharide vaccine from meningococcal serogroup A and C, freeze-dried powder to be diluted with a solvent.
There are vials of powder for 10 doses and 50 doses.
- Administration in deep subcutaneous or IM injection in the deltoid muscle of the arm.

Dosage and vaccination scheme

- Child and adult :0.5 ml
- Age of administration

· meningococcus type A: from 3 months of age
· meningococcus type C: the vaccine is effective only if given after 18 months of age

- Efficiency: 1 week after injection for 3 years (if injection after 2 years of age)

Contra-indications, side-effects, precautions

- There are no contra-indications.
- There are no side-effects, vaccine is well tolerated.
- In some cases, redness at injection site for 24 hours.
- In 0.4% of the cases, fever (up to 38.5°C).
- Pregnancy: no contra-indication
- Lactation: no contra-indication

Remarks

- It is always better to use the solvent delivered with the vaccine. In case of loss, we recommend sodium chloride 0.9% or water for injection as the solvent, using the same quantity as the solvent delivered.
- Combinations

· Simultaneous combination (at the same time, in a separate syringe)
Compatible with other vaccines given by EPI.
· Combinations with other vaccines (in the same syringe)
Possible with measles and antiamaril vaccine.

- Storage

· Freeze-dried powder
Store between 0 and 8°C.
Freezing (-20°C) recommended for long periods.
The freeze-dried vaccine is very stable (18 months: at 37°C; 4 weeks: at 45°C).
· After dilution
Store between 0 and 8°C is possible.
Vaccine remains stable for 4 days at 37°C, but, for asepsis, it is preferable to destroy the vial when the vaccination session is over.
At the moment of dilution, the solvent must be at the same temperature as the vaccine (0 to 8°C).

ANTITETANIC SERUM equine tetanus antitoxin

District hospital

Therapeutic action

- Neutralises the tetanus toxin

Indications

- Prevention of tetanus for non-vaccinated wounded patients
- Treatment of tetanus

Preparation and route of drug administration

- Ampoule (or ready-to-use syringe) of 1,500 IU/ml, 1 ml for SC or IM injection Serum equine origin (horse)

Dosage

- Prevention of tetanus: 1,500 IU
- Treatment of tetanus

· Newborn: 1,500 IU
· Child : 5,000 IU
· Adult : 10,000 IU

It is necessary to administer the injection following the Besredka method: inject 0.1 ml, wait 15 minutes leaving the needle and syringe in place, inject 0.25 ml and wait 30 minutes; if there is no reaction, finish the injection.

- Efficiency: during 1 to 2 weeks.

Duration: single dose

Contra-indications, side-effects, precautions

- Do not administer if known allergy to anti-tetanic serum.
- May cause severe, sometimes deadly, allergic reactions.
- Anti-tetanic serum only has a transitory action and must be combined with anti-tetanic vaccination.
- Pregnancy: CONTRA-INDICATED
- Lactation: no contra-indication

Remarks

- In cases of tetanus, immediately apply antibiotic and symptomatic treatment.
- Anti-toxin from human origin (tetanus immunoglobulin) exists. It does not cause allergic reactions and is not contra-indicated during pregnancy, but it is much more expensive.
- This product is not included in the WHO essential drug list.
- Storage: keep refrigerated, between 2 and 8°C. Do not freeze.

BCG VACCINE (Glutamate BCG vaccine)

Health clinic

Indications

- Prevention of tuberculosis
- Must be integrated in the national Expanded Program of Immunization (EPI)

Presentation and route of drug administration

-Live attenuated bacterial vaccine, freeze-dried powder to be diluted with a solvent. There are vials of powder for 10 doses, 20 doses and 50 doses, with the vials of special solvent.
-Injections are given strictly intracutaneously ("pig skin") in the middle third of the upper arm, external side.

Dosage and vaccination scheme

- 0.05 ml for child under 1 year.
- 0.10 ml for child abeve 1 year.
-BCG is given at birth in a single dose. If after 3 months, there is no scar, BCG vaccine must be repeated (maximum 3 times).
- Efficiency: (80%) during 10 years.

Contra-indications, side-effects, precautions

- Absolutely contra-indicated in patients with Acquired or Congenital Immune Deficiency Syndrome (AIDS).
- Contra-indicated in cases of progressive dermatoses.
- Normal local reaction: after 2 to 4 weeks, appearance of a small red nodule, becoming a vesicle. - This reaction will remain for 2 to 5 months and leave a superficial scar, 2 to 10 mm in diameter.
- Possibility of abscess on the scar (Becegitis).
- Presence of an axillary or cervical adenitis in 1 to 4% of the cases, 2 to 3 months after the injection. The adenitis may sometimes cause suppuration and fistulization.
- Fatal disseminated infections with the BCG are very seldom.

Remarks

- It is always better to use the solvent delivered with the vaccine. In case of loss, we recommend sodium chloride 0.9% or water for injetion as the solvent, using the same quantity as the solvent delivered.
- Combinations

· Simultaneous combination (at the same time, in a separate syringe)
Compatible with other vaccines given by EPI.

· Combinations with other vaccines (in the same syringe)
Impossible.

-Storage

· Freeze-dried powder
Store between 0 and 8°C.
Freezing is possible.
Defrosting/re-freezing is possible. At 37°C, stability of the freeze-dried vaccine is very variable, with loss of effectiveness after 3 to 14 days.

· After dilution
Keep for maximum 5 to 6 hours between 0 and 8°C.
Protect from light.

DPT VACCINE (DTP, DTCoq)

Health clinic

Indications

-Prevention of diphteria, tetanus and pertussis
-Must be integrated in the national Expanded Program of Immunization (EPI)

Presentation and route of drug administration

-Adsorbed vaccine (diphtheric and tetanic toxoid and killed bacterial vaccine against pertussis), ampoule with ready to use solution.
There are ampoules of 10 doses, 20 doses and 50 doses.
-Administration in deep subcutaneous or IM injection in the outer part of the mid-thigh or in the deltoid muscle of the arm.

Dosage and vaccination scheme

- 0.5 ml per injection
3 injections given 4 weeks apart, followed by a booster 1 year after the 3rd dose.
- Age of administration
The first dose may be given from 6 weeks of age.
- Efficiency: during several years after 3 doses.

Contra-indications, side-effects, precautions

- Contra-indicated if history of neurological disorder.
- In case of significant reactions after the first dose of DTP (high fever, convulsions, neurological signs), only give diphtheria-tetanus vaccine.
- Febrile reactions (39° - 40°C) during approximately 48 hours.
- Local reactions: induration and painful reaction at injection site.
- Complications are often due to the anti-pertussis component: toxic shock, encephalopathies.

Remarks

-Combinations

· Simultaneous combination (at the same time, in a separate syringe)
Compatible with other vaccines given by EPI.
· Combinations with other vaccines (in the same syringe)
Possible with measles vaccine (DPT serves as solvent).

-Storage
Between 2 and 3°C.
NEVER FREEZE: if frozen, the adjuvant can cause aseptic abscesses and a poor diffusion of the vaccine.
At 37°C, the vaccine will remain stable for 6 weeks.
Attention: univalent pertussis vaccine: will remain stable for only 3 to 7 days at 37°C.

MEASLES VACCINE (Rouvax, Morbilvax, Rimevas)

Health clinic

Indications

- Prevention of measles

Must be integrated in the national Expanded Program of Immunization (EPI)

Presentation and route of drug administration

- Live attenuated viral vaccine (Schwarz strain), freeze-dried powder to be diluted with a special solvent.
There are vials of powder for 10 doses, 20 doses and 50 doses, with the vials of solvent.
- Administration in deep subcutaneous or IM injection in the outer part of the mid-thigh or in the deltoid muscle of the arm.

Dosage and vaccination scheme

- 0.5 ml in a single dose
- Age of administration

· From the age of 9 months to 5 years.
· If the population is concentrated, 2 doses may be given:
1 first dose from 6 months of age (between 6 and 8 months),
1 second dose from of 9 months of age.

- Efficiency: undefinitly, some days after injection (when injection after 9 months of age)

Contra-indications, side-effects, precautions

- Contra-indicated in case of genuine allergy to eggs.
- Wait 6 weeks after injection of gammaglobulins to give measles vaccine.
- Local reactions: none.
- Generalized reactions:

· fever after 5 to 10 days (in 15% of the cases),
· cutaneous rash for 48 hours,
· rhinopharyngitis.

- Complications:

· hyperthermic convulsions,
· encephalitis (1 case in 1 million vaccinations).

Remarks

- It is always better to use the solvent delivered with the vaccine. In case of loss, we recommend water for injection (distilled water) as the solvent, using the same quantity as the solvent delivered.
- A new high dose strain vaccine (AIK C, Edmonstron Zagreb), administered as of the age of 6 months in a single dose of 0.5 ml in deep subcutaneous ir IM injection, should be available in the near future.
- Combinations

· Simultaneous combination (at the same time, in a separate syringe)
Compatible with other vaccines given by EPI.
· Combinations with other vaccines (in the same syringe)
Possible with the DPT vaccine, which can be used as solvent, and with antimeningococcal and antiamaril vaccine.

- Storage

· Freeze-dried powder
Store between O and 8°C.
Freezing (-20°C) recommended for long periods.
Defrosting/re-freezing is possible, but not advisable.
At 37°C, the freeze-dried vaccine is stable for 7 days.

· After dilution
Store between 0 and 8°C, maximum 8 hours; at 37°C, maximum 1 hour.
At the moment of dilution, the solvent must be at the same temperature as the vaccine (0 to 8°C).
Protect from light.

ORAL ANTIPOLIOMYELITIS VACCINE (Polioral trivalent, Polio Oral Sabin, Oral Poliomyelitis

Health clinic

Indications

- Prevention of poliomyelitis (for the 3 types of polio 1, 2 and 3)
- Must be integrated in the national Expanded Program of Immunization (EPI)

Presentation and route of drug administration

- Live attenuated viral vaccine, monovalent (Sabin), vial with liquid vaccine, limpid and pink colored, ready for administration (do not use the vaccine when cloudy). There are vials of 10 doses, 20 doses, 25 doses and 50 doses, with a plastic dropper.
- Administration: orally, on the tongue.

Dosage and vaccination scheme

- 2 to 3 drops (depending on manufacturer)
Three doses of vaccine must be given, minimum 4 weeks apart.
- Age of administration
The first dose is administered at the age of 6 weeks at the same time as DPT.
The WHO recommends an additional dose at birth (Polio zero).
- Efficiency: 5 years after 3 doses.

Contra-indications, side-effects, precautions

- Contra-indicated in case of immunodeficiency.
- Diarrhoea is not a contra-indication, but it is preferable to give a supplementary dose once the child is cured.
- No reactions to this vaccine.
- Complications: 1 case of encephalitis out of 3 million administered doses.
- Pregnancy: CONTRA-INDICATED during the first trimester of pregnancy, except if there is a major risk for poliomyelitis.
Lactation: no contra-indication

Remarks

- Other antipoliomyelitis vaccines: injectable inactivated vaccine.
Not used very often in developing countries because of the high cost.
- Combinations

· Simultaneous combination (at the same time, in a separate syringe)
Compatible with all other vaccines given by EPI.
· Combinations with other vaccines (in the same syringe)
Impossible since this is an oral vaccine and not an injection.

- Storage
Between 0 and 8°C.
Freezing (-20°C) recommended for long periods.
Defrosting/re-freezing is possible.
Stability: the most fragile vaccine (1 day: at 37°C; 1 to 3 hours: at 50°C).

TETANUS VACCINE (Tetanus toxoid, Tetanol)

Health clinic

Indications

- Prevention of tetanus
- Must be integrated in the national Expanded Program of Immunization (EPI)

Presentation and route of drug administration

- Adsorbed tetanic toxoid, monovalent, vial with ready to use solution.
There are vials of 10 doses, 20 doses and 50 doses.
- Administration in deep subcutaneous or IM injection in the outer part of the mid-thigh or in the deltoid muscle of the arm.

Dosage and vaccination scheme

- 0.5 ml per injection.
Vaccinate all women of child-bearing age. 5 doses are needed to give a definitive immunization status.
- Newborn child: give 3 doses, one month apart, followed by boosters later. 5 doses are needed to give a definitive immunization status.

Contra-indications, side-effects, precautions

- Slight but rare side-effects, this vaccine is extremely well tolerated.
- Painful, red reaction at injection site possible.
- Complications: none.

Remarks

- Combinations

· Simultaneous combination (at the same time, in a separate syringe)
Compatible with other vaccines given by EPI.
· Combinations with other vaccines (in the same syringe)
Possible with anti-pertussis, diphtheria and polio vaccine.

- Storage
Between 2 and 8°C.
NEVER FREEZE: if frozen, the adjuvant can cause aseptic abscesses and poor
diffusion of the vaccine.
At 37°C, the vaccine remains stable for at least 2 months.
Antitetanic toxoid is the vaccine the most resistant to heat

Drugs for external use and Disinfectants

Benzoic acid + Salicylic acid
Benzyl benzoate
Calamine lotion
Cetrimide
Chloramine T = Chloramine
Chlorhexidine
Chlorhexidine + Cetrimide
Chlorine
Chlortetracycline, eye ointment
Cresol
Dakin's solution
(Ethyl) alcohol
Ethanol 70%
Gentian violet
Iodine (alcoholic solutions)
Lysol
Merbromine
Mercuresceine sodium
Methylrosanilinium chloride
Oxytetracycline, eye ointment
Polyvidone iodine = PVI
Potassium permanganate
Tetracycline, dermal ointment
Tetracycline, eye ointment
Tosylchloramide sodium
Whitfield's ointment
Zinc Oxide (vaseline)

BENZOIC ACID + SALICYLIC ACID ointment = Whitfield's ointment

District hospital

Therapeutic action

- Antifungal and keratolytic

Indications

- Fungal infection of the skin
- Fungal infection of the scalp (tinea)

Preparation

- Ointment with 3% salicylic acid and 6% benzoic acid

Dosage

- 2 applications per day

Duration

- 3 weeks minimum depending on progress

Precautions

- Do not apply to open wounds or mucous membranes (mouth, nose, vagina, rectum).
- Local irritation and inflammation can occur (if a severe reaction, stop treatment).

Remarks

- Storage: exposure to high temperature may cause the active parts to separate from the mixture. Stir well before use.

BENZYL BENZOATE = BENZOATE DE BENZYLE (BBL (R).)

Health post

Therapeutic action

- Parasiticidal preparation for external use (skin)

Indications

- Scabies
- Pediculosis (lice)

Preparation

- Emulsion containing 25% benzyl benzoate
- Concentrated emulsion containing 90% benzyl benzoate

FIGURE

Directions for use

- Shake well before use.
- For the treatement of scabies
Warning: in case of secondary infection, first clean and apply gentian violet for several days before applying benzyl benzoate.

· Wash the patient.
· Apply the product all over the body, except for the face and the mucous membranes.
· Leave the product on the body for 24 hours (12 hours for children under 2 years).
· Wash.
· Repeat the following morning if possible, washing the patient between the two applications.

- For the destruction of lice

· Apply the product, leave for 24 hours (12 hours for children under 2 years), wash the patient afterwards.

Precautions

- NEVER SWALLOW: VERY DANGEROUS.
- In case of ingestion, DO NOT INDUCE VOMITING, refer to a doctor.
- Do not apply to mucous membranes (mouth, nose, vagina, rectum).
- Lactation: avoid applying to the nipples.

Remarks

- Examine the other family members and treat everyone affected with scabies simultaneously. Have the clothing and bed linen washed with boiling water.
- Itching can continue for several days which does not imply that the treatment is ineffective.
- The concentration recommended by WHO is 25%.

Storage: no special precautions

CALAMINE lotion and Vaseline with ZINC OXIDE

District hospital

Therapeutic action

- Astringent, soothing, antipruritic
- Skin protection

Indications

- Burns
- Eczema
- Psoriasis
- Varicose ulcers

Preparation

- Calamine lotion (15% zinc carbonate)
- Vaseline with 10% zinc oxide, jar or tube

Dosage

- 1 to 3 applications per day

Duration

- Depending on clinical progress.

Precaution

- Clean and disinfect the skin well before applying the ointment or lotion.

Remarks

- These two products are used in the same way. In general, calamine lotion is better known in english speaking countries and zinc oxide in french speaking countries.
- Zinc oxide can be used to replace sterile paste for burns: sterilize in a pressure-cooker or heat while stirring until boiling point, allow to cool, coat the sterile compresses and apply.
- Storage: no special temperature requirements. Exposure to high temperatures may cause the active parts to separate from the mixture. Stir well before use.

CETRIMIDE (Cetavlon (R).)

The use of this drug is not advised:

- it has almost no advantage over ordinary scop;
- the aqueous solution is very often contaminated;
- it is not included in the WHO essential drug list.

Therapeutic action

- Antiseptic detergent and disinfectant

Indications

- Cleaning of wounds
- Cleaning of dirty materials

Preparation

- Powder for dissolving
- Concentrated solution of 20% to be diluted
- Concentrated solution of 40% to be diluted

Dilution

- It is used in a 1% solution of cetrimide
10 g of powder in 1 litre of water
or 50 ml of the solution of 20% in 950 ml
or 25 ml of the solution of 40% in 975 ml
- Prepare the solutions with drinking water from the water mains or use boiled water, filtered if necessary.
- Wash the bottle carefully with hot water and let it dry before refilling.

Precautions

- The aqueous solution diluted for use are easily contaminated by pathogenic germs (if possible, prepare the solution just before use).
- Incompatible (causes inactivation) with soap and iodine (polyvidone iodine).
- Not suitable for the sterilization of instruments (nor for sterile storage).

Remarks

- Use of the product is not advised (limited efficiency and high risk of contamination of the aqueous solutions).
- The combination of chlorhexidine + cetrimide is much more efficient.
- Storage. no special precautions
Never keep diluted solutions for more than 1 week.

CHLORAMINE = CHLORAMINE T = TOSYLCHLORAMIDE SODIUM

Health clinic

Therapeutic action

- Antiseptic and disinfectant (generates chlorine)

Indications

- Antiseptic

· Cleaning of dirty wounds
· Disinfection of wounds or infected mucous membranes (abscess, ulcers.)

- Disinfectant

· Disinfection of medical instruments
· Disinfection of floors, surfaces, various objects.

Preparation

- Powder or tablets of 250 mg, 500 mg or 1 g, with a slight odour of chlorine. The tablets must be easily and completely soluble, otherwise the powder is preferable.

Dilution

- Antiseptic

· For general use :5 g per litre
· For repeated use on mucous membranes: 2 g per litre

- Disinfectant

· Disinfection of instruments: 20 g per litre
· Disinfection of floors, surfaces, various objects: 5 g per litre

- Prepare the solutions with drinking water from the water mains or use boiled water, filtered if necessary.

Use

- For wounds and mucous membranes: bath, irrigation or compresses (solutions of chloramine are better than DAKIN). For prolonged use, protect the healthy skin around the wound with vaseline.
- Rapid disinfection of instruments and laboratory equipment: soak for 15 minutes in a solution of 20 g/litre (the instruments must be cleaned first).

Precautions

- Protect people from accidental swallowing of the tablets: DO NOT STORE NEAR ORAL TABLETS.

Remarks

- There are tablets of 12 or 20 mg for the disinfection of drinking water for individuals and families (1 tablet per litre clear water).
- 1 g of chloramine generates 250 mg of active chlorine.

- Storage:

· Storage of r eady to use solutions: maximum 1 week.
· The solutions use for soaking instruments must be renewed every day.
· The solutions must be stored in the shade and protected from direct sunlight: use an opaque bottle or brown glass (do not use a metal container).

CHLORHEXIDINE (Hibitane (R).)

Health post

Therapeutic action

- Antiseptic

Indications

Cleaning and disinfection of:

- skin and mucous membranes
- wounds
- burns
- ulcers
- abscesss

Preparation

- Concentrated solution of 5% chlorhexidine digluconate to be DILUTED before use. Check whether the supplied concentrated solution can be diluted with non-distilled, ordinary water (in this case, the solution must contain a cosolvent).
- There are solutions of 20% chlorhexidine, but they contain generally no cosolvents and must therefore be DILUTED WITH DISTILLED WATER to avoid a possible precipitation of chlorhexidine.

Dilution

- Used in an aqueous solution of 0.05% chlorhexidine = 10 ml of the 5% solution in 1 litre of water.
- Use drinking water from the water mains or boiled water, filtered if necessary.
- Wash the bottle carefully with hot water and let it dry before refilling.

Precautions

- Do not bring into contact with cerebral tissue, the meninges or an injured ear-drum.
- Do not use with soap (rendered inactive).
- Do not use for cleaning the ears.
- Not suitable for the sterilization of instruments (nor for sterile storage).

Remarks

- The combination of chlorhexidine + cetrimide is more useful: better detergent properties (cleaning) and it can always to be diluted with non-distilled water (cetrimide operates as a cosolvent).
- Storage:

· concentrated solution: no special precautions.
· solution diluted ready for use: maximum 1 week

CHLORHEXIDINE + CETRIMIDE (HAC (R)), Savlon(R).)

Health post

Therapeutic action

- Combination of an antiseptic and a detergent

Indications

Cleaning and disinfection of:

- skin and mucous membranes
- wounds
- burns
- ulcers
- abscesss
- various objects

Preparation

- Concentrated solution of 1.5% chlorhexidine and 15% cetrimide to be DILUTED before use.

Dilution

- Make a 2% solution from the concentrate: 20 ml of the concentrated solution in 1 litre of water. This solution contains 0.03% chlorhexidine and 0.3% cetrimide.
- Use drinking water from the water mains or boiled water, filtered if necessary.
- Wash the bottle carefully with hot water and let it dry before refilling.

Precautions

- Do not bring into contact with cerebral tissue, the meninges or an injured ear-drum.
- Do not use with soap (rendered inactive) or with an iodine disinfectant (e.g. polyvidone iodine).
- Do not use for cleaning the ears.
- Not suitable for the sterilization of instruments (nor for sterile storage).

Remarks

- Storage:

· concentrated solution: no special precaution.
· solution diluted ready for use: maximum 1 week

Products that generate CHLORINE (Calcium hypochlorite = HTH, Chlorinated lime, Bleach, Sodium dichloroisocyanurate or NaDCC)

Therapeutic action

- Strong disinfectants (generate active chlorine)

Indications

- Disinfection of objects, instruments, linen.
- Disinfection of floors, surfaces (tables, sinks.)

Preparation

- Calcium hypochlorite grains (HTH).+/-70% active chlorine
- Chlorinated lime powder, bleaching powder+/- 25% active chlorine
- Solutions of sodium hypochlorite (bleach, Milton(R):

· Bleach 12° chlorometrical degrees. +/- 4% active chlorine
· Bleach 15° chlorometrical degrees.+/- 5% active chlorine
· Concentrated bleach 48° chlorometrical degrees. +/- 15% active chlorine
(to be diluted in 3/4 litre water to become bleach with 4% active chlorine)

- Sodium dichloroisocyanurate or NaDCC:

· Powder.60-65% active chlorine
· Tablets (Javel solid(R)) 1.5 g active chlorine per tablet

The power of the disinfectants that generate chlorine is expressed in active chlorine (generally percentage in active chlorine).

The amount of active chlorine is sometimes expressed in chlorometrical degrees.
1° chlorometrical = approximately 0.3% active chlorine

The amount of chlorine in diluted solutions is expressed in% or in ppm (parts per rnillion) of active chlorine (1 ppm = 1 mg/litre = 0.0001%).

Dilution

- The amount of active chlorine must always be checked on the packaging of the product to correct the dosage if necessary.
- In certain conditions, solutions with a stronger content of active chlorine can be made by adjusting the dosage.
- Always dilute in non-metal containers just before use.
- A deposit in HTH or chlorinate lime solutions is normal (use the upper part). - Prepare solution with clean water.

FIGURE

Precautions

- Handle the concentrated products with care (avoid jolts and exposure to high temperatures or flames).
- Avoid inhaling vapours and dust when opening or handling the containers.
- Do not mix with detergents.
- Do not bring the dry product, particularly calcium hypochlorite, in contact with organic materials (for example: corpses): risk of explosion.
- Disinfection of linen

Only suitable for cotton and linen (but risk of discolouration). Soak for maximum 15 minutes. Do not exceed 0.1% (1,000 ppm) of active chlorine. Rinse abundantly (at least 3 times) with clear water after soaking.

- Disinfection of instruments
To avoid corrosion, use only for stainless steel instruments. Do not use solution containing more than 0.1% (1,000 ppm) of active chlorine frequently, do not leave in contact for more than 30 minutes, instruments and solution should be cold, rinse abundantly and dry after disinfection.
- NaDCC is less corrosive than solutions of calcium hypochlorite and bleach.

Remarks

- Chloramine T (sodium tosylchloramide) also produces chlorine (25% active chlorine), but acts more slowly than the products described above. It is especially suitable as an antiseptic for infected wounds and mucous membranes because it is less irritating.
- Calcium hypochlorite, bleach and concentrated bleach can be used to prepare antiseptic solutions (DAKIN solution) if 1 teaspoon of sodium bicarbonate is added to the final solution (to neutralise the alkalinity).

· For wounds: solution of 0.1% (1,000 ppm) active chlorine.
· For mucous membranes: solution of 0.05% (500 ppm) active chlorine.

- Trichloro-isocyanuric acid containing 90% of active chlorine is very similar to NaDCC, but its use is limited by poor solubility. It is mainly used for chlorination of pool water as pellets placed in a float.
- Storage:

· Store in air-tight containers: protectedfrom light and heat (and humidityfor solids).
· Chlorinated lime, bleach and concentrated bleach are difficult to keep (maximum a few months for the last two).
· Calcium hypochlorite is relatively easy to keep.
· NaDCC is much more stable.

Soapy solution of CRESOL = Lysol

District hospital

Therapeutic action

- Disinfectant and detergent

Indications

- Cleaning and disinfection of materials (floors, objects, instruments, surfaces, linen.)

Preparation

- Concentrated solution (containing 50% cresol and 50% liquid soap) to be DILUTED before use

Dilution

- Dilute in water just before use: 2 to 5% depending on amount of dirt (1 part of concentrated solution in 20 to 50 parts of water = 200 to 500 ml for 10 litres of water)

Use

- Objects and instruments
Soak in the diluted solution during 30 minutes, brush with care, rinse and sterilize if necessary.
- Rooms
Evacuate the patients, clean with the diluted solution, rinse and ventilate to eliminate the smell and irritating odour.
- Linen
Soak in the diluted solution during 6 hours, rinse abundantly.

Precautions

- Do not confuse with pure cresol, without soap (see remarks).
- Do not use for the disinfection of food, or for materials than can come in contact with drinking water or food.
- Very irritating for skin and mucous membranes:

· Never use for wounds, skin.
· Avoid contact with the hands.

Remarks

- Lyorthol (R), sodium cresylol, Cresyl (R), Creolin (R), chloroxylenol 5%, Dettol (R), are similar products used for the same purposes and diluted in the same way, but Dettol (R) can also be used for skin, wounds and mucous membranes.
- Cresol (without soap) can be used but is not advised since it is more difficult to dissolve in water and is more irritating than the soapy solution. Furthermore, it has no detergent properties and stains linen.
- Storage: keep containers tightly closed.

(ETHYL) ALCOHOL = ETHANOL 70%

The use of this drug is not advised for general use: it is expensive, irritating and less effective than polyvidone iodine or chlorhexidine

Therapeutic action

- Antiseptic

Indications

- Used only for disinfection and cleaning of healthy skin before injections.

Preparation

- Alcohol of 95%, 92%
1 litre of 95% alcohol contains 950 ml of pure alcohole. Use diluted.

Dilution

- To obtain 1 litre of 70% alcohol from 95% alcohol, you need approximately 740 g (737 ml) of 95% alcohol and 260 g (263 ml) of distilled or filtered water. 95% alcohol must always be diluted 70% alcohol has the best antiseptic strength.

Contra-indications, side-effects cautions

- Do not apply to the eyes, mucous membranes, wounds or burns.

Remarks

- Can be easily replace polyvidone iodine. The use of alcohol can be justified only when it is available locally at a competitive price.
- Dilution can be expressed in% or in alcoholic degres: alcohol 95% = alcohol 95°.
- Storage: keep below 30 C
Close bottles tightly to avoid evaporation.

Alcoholic solutions of IODINE (iodised alcohol, iodine tincture)

The use of this drug is not advised: see remarks

Therapeutic action

- Strong, rapid acting antiseptic
- Antifungal

Indications

- Disinfection of healthy skin (surgery, injection or puncture)
- Treatment of fungal skin infection.

Preparation

- Iodised alcohol (1 or 2% in ethanol 70 or 80°)
- Iodine tincture (5% in ethanol 80 or 90° + 3% potassium iodine) is very concentrated preparation that should no longer be manufactured or prepared.

Precautions

- Very irritating solutions.
- Can provoke allergic reactions.
- Should not be used on wounds as it is painful and slows the healing process.
- Incompatible with mercury derivatives.

Remarks

- Alcoholic solutions of iodine have very limited use. They are very irritating, expensive and difficult to preserve; the alcohol evaporates (solutions become even more irritating as they age).
- They should be replaced by polyvidone iodine that is much less irritating and easier to preserve (see polividone iodine).
- Storage: maximum of a few weeks

MERBROMINE = MERCURESCEINE SODIUM (Mercurochrome(R).)

The use of this drug is not advised:

- it is toxic and allergenic;
- as an antiseptic, it is weak and expensive;
- it is not included in the WHO essential drug list.

Therapeutic action

- Antiseptic

Indications

- Disinfection of small superficial wounds

Preparation

- Powder to be dissolved
- Aqueous solutions of 1 or 2% ready for use
- Alcoholic solutions of 2% ready for use

Precautions

- Toxic for kidneys, nervous system and digestive system (resorption of mercury through skin).
- Allergic reactions, frequently accompanied by a sensitivity to all mercury derivatives (other mercury antiseptics, amalgam for dental applications, preservation agents in cosmetics..).
- Colours the skin which can mask an inflammatory reaction.
- Never use together with an iodine product (iodised alcohol, polyvidone iodine): risk of necrosis.

Remarks

- The aqueous solutions; have a very weak antiseptic capacity.
- The alcoholic solutions are more efficient but mercuresceine has such a high level of toxicity that its use, in all forms, should be banned.
-Storage:

· Powder and alcoholic solutions: no special precautions.
· Aqueous solutions: never preserve diluted solutions for more than 1 week.

METHYLROSANILINIUM CHLORIDE = GENTIAN VIOLET = GV = Crystal violet

Health post

Therapeutic action

- Antifungal
- Antiseptic
- Drying

Indications

- Treatment of fungal infections of:

· the skin
· the scalp (tinea)
· the oral and vaginal mucous membranes

- Treatment of wet dermal disorders (eczema, impetigo.)
- Treatment of burns and superficial wounds

Preparation

- Powder to be dissolved
- Solution of 0.5%

Dilution

- It is used in a 0.5% solution = 5 g per litre (saturated solution). Dissolve one teaspoon in 1 litre of water. Stir several times and leave to settle. Filter through cotton or pour carefully into another bottle to eliminate possible sediment.
- Use drinking water from the water mains or boiled water, filtered if necessary.
- Wash the bottle carefully with hot water and let it dry before refilling.

Use

- Apply once a day.
- The solution can be applied in the mouth without danger.

Precautions

- May cause permanent pigmentation (do not use on the face of light skinned people).

Remarks

- Storage:

· of powder: unlimited.
· solution diluted ready for use: maximum 1 week.

POLYVIDONE IODINE = PVI (Betadine (R), Videne (R).)

District hospital

Therapeutic action

- Antiseptic and disinfectant

Indications

- Disinfection of the skin, wounds and burns
- Treatment of fungal and other skin infections, and skin manifestations caused by certain viruses (herpes, shingles.)
- Disinfection of medical instruments
- Disinfection of the hands before surgery

Preparation

- Concentrated solution of 10% PVI to be used pure or diluted

Dilution

- Pure (= solution 10% PVI) for the disinfection of the skin.
- Diluted to 2.5% PVI for the disinfection of wounds, burns and instruments (1 part of concentrated solution of 10% + 3 parts water).
- Diluted to 0.5% PVI for the mucous membranes (1 part of concentrated solution of 10% + 19 parts water).
- Prepare the dilutions with drinking water from the water mains or boiled water, filtered if necessary.

Use

- Disinfection of the skin

· Before injection or setting up IV catheter: one application of the diluted solution of 2.5% PVI (if the skin is dirty, first wash with soap and water).
· Before surgery: two applications of concentrated solution (10% PVI) after washing with soap and water, rinsing and drying.

- Disinfection of the umbilical cord
Concentrated solution (10% PVI).
- Treatment of fungal skin infections and viral manifestations (herpes, shingles)
Concentrated solution (10% PVI) twice a day.
- Disinfection of wounds and burns
One application of diluted solution of 2.5% PVI every time the dressing is changed.
- Treatment of infections and fungi on mucous membranes
Diluted solution of 0.5% PVI twice a day.
- Rapid disinfection of stainless steel instruments
Soak the clean instruments for 15 minutes in the diluted solution of 2.5% PVI.
- Disinfection of the hands
After careful and prolonged washing with soap, and rinsing with boiled water, rub the
hands while still damp with a small amount of 10% PVI solution until dry.

Precautions

- Do not use repeatedly on very large surfaces or with infants.
- Never use with a mercury derivative (e.g. Mercurochrome (R), certain disinfecting soaps) because of necrosis risk.
- Stop treatment if allergic reaction.

Remarks

- Relatively expensive product, but very efficient and polyvalent.

Storage:

· Concentrated solution 10% PVI: no special precautions.
· Diluted solution of 2.5% PVI: maximum 1 week.
· Diluted solution of 0.5% PVI: prepare just before use.
· Solution used for the disinfection of instruments: renew every day.

POTASSIUM PERMANGANATE

The use of this drug is not advised:

- the risk of misuse is too great;
- it is not included in the WHO essential drug list.

Therapeutic action

- Antiseptic
- Astringent

Indications

- Superficial wounds.
- Eczema.
- Fungal infection, in particular of the toes (athlete's foot)

Preparation

- Dark crystal violet to be dissolved
- Tablets to be dissolved; exist in various doses: 0.25 g, 0.50 g and 1 g

Dilution

- Dilute to 0.01% (100 mg in 1 litre water)
- The concentration must be precise:

· if it is too high: caustic
· if it is too low : inefficient

Scales must be used to obtain the proper concentration from the crystals.

Precautions

- Handle the dry product the concentrated solutions with care (burning of the skin and risk of explosion when brought in contact with an easily oxidizable material).
- Take precautions to avoid swallowing the tablets. Do not store near oral tablets, INGESTION IS VERY HARMFUL: risk of digestive perforation.
- Repeated applications will dry out the skin.

Remarks

-This product has no special advantages, except for its cheap price.
- Its use is discouraged because of constant mistakes in dilution and the risk of ingestion of the tablets.
- Storage:

· dry product: protect against air (air-tight containers).
solution diluted for use maximum 1 week.

TETRACYCLINE dermal ointment

The use of this drug is not advised:

- local applictions of antibiotics also utilised orally increase
- the risk of selecting resistent strains of bacteria.

Therapeutic action

- Antibacterial

Indications

- No indications. The use of antibacterial ointments is discouraged (risk of selecting resistant strains). Regular washing with antiseptic is often enough to heal a skin infection. If this fails, the treatment with oral antibiotics is preferable.

Preparation

- Ointment of 3% tetracycline (tube of 15 g or jar of 1 kg)

Precautions :

- Do not apply the dermal ointment to the eyes. Use only eye ointment for the eyes.

Remarks

- Storage: keep below 30°C.
Do not use after the expiry date.

TETRACYCLINE eye ointment CHLORTETRACYCLINE eye ointment and OXYTETRACYCLINE eye ointment

Health post

Therapeutic action

- Antibacterial

Indications

- Eye infections (conjunctivitis)
- Trachoma
- Prevention of eye infections in the newborn (chlamydia and gonococcus)

Preparation

- Sterile ointment of 1% or 3% (tube of 5 g)

Dosage

Applied under the eyelids.

- Conjunctivitis :2 applications per day for 1 week.
- Trachoma: 2 applications per day for 4 to 6 weeks.
- Prevention of eye infections in the newborn: 1 single application at birth.

Duration

- Depending on indications

Precautions

- Allergic reactions possible. Stop treatment and refer to a doctor.

Remarks

- The ointments of 1% and 3% are used in the same way.
- Do not apply the dermal ointment to the eyes. Use only eye ointment for the eyes.
- The tetracycline eye ointment is better than SILVER NITRATE for the prevention of conjunctivitis in the newborn.
- Oxytetracycline and chlortetracycline are used in the same way as tetracycline.
- Storage: keep below 30°C.
Do not use after the expiry date.
After opening, close the tube well to avoid contaminahon.