Urethral Discharge Syndrome in Men
Gonorrhea is the main cause of urethritis among clinic attendees
in most developing countries. In recent years, however, as diagnostic techniques
for chlamydia have become more sensitive, the role of chlamydial and mixed
infections in causing urethritis in developing countries is also becoming better
defined. Some clinicians rely on the characteristics of urethral discharge to
differentiate between gonococcal and non-gonococcal urethritis (NGU). Gonococcal
urethritis tends to be more purulent and NGU more mucoid. However, these
clinical signs are not sufficiently discriminatory to predict the etiology or
cause of urethral discharge in a given patient.17 In addition, they
can be confounded by prior, ineffective treatments patients may have taken
before coming to the clinic.
Two examples of flowcharts for urethral discharge are shown in
Figures 2 and 3. The first example (Figure 2) is a simple syndromic management,
treating every man with a complaint of urethral discharge for gonorrhea and NGU.
A sequential treatment (first, treatment for gonorrhea and if this fails,
treatment for NGU) has been the policy in the past in some countries in order to
limit unnecessary treatments. However, because of a large proportion of missed
chlamydial infections, and because many patients fail to come back, this
approach can no longer be recommended.

Figure 2 - Management of Urethral
Discharge - HONDURAS
In the second flowchart (Figure 3), Gram stain is added to a
syndromic approach. Depending on the result of the Gram stain, a syndromic
treatment or a treatment for NGU will be given. This approach offers the
advantage of reducing unnecessary treatments (including expensive gonorrhea
drugs) for the patient and his partner by increasing the specificity of the
flowchart.

Figure 3 - Management of Urethral
Discharge - JAMAICA
A flowchart including Gram stain can only be considered when
laboratory facilities are available. Results should be given within a reasonable
time so patients do not have to return to the health facility for treatment the
next day. This approach reduces the risk of serious complications, acute
morbidity associated with either gonorrhea or chlamydia, and further
transmission of the causative
organism.